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Brandon J. DeKosky
Researcher at University of Kansas
Publications - 60
Citations - 4135
Brandon J. DeKosky is an academic researcher from University of Kansas. The author has contributed to research in topics: Antibody & Antigen. The author has an hindex of 19, co-authored 50 publications receiving 3205 citations. Previous affiliations of Brandon J. DeKosky include University of Texas at Austin & University of Texas System.
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Journal ArticleDOI
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies.
Nicole A. Doria-Rose,Chaim A. Schramm,Jason Gorman,Penny L. Moore,Jinal N. Bhiman,Brandon J. DeKosky,Michael J. Ernandes,Ivelin S. Georgiev,Helen J. Kim,Marie Pancera,Ryan P. Staupe,Han Altae-Tran,Robert T. Bailer,Ema T. Crooks,Albert Cupo,Aliaksandr Druz,Nigel Garrett,Kam Hon Hoi,Rui Kong,Mark K. Louder,Nancy S. Longo,Krisha McKee,Molati Nonyane,Sijy O'Dell,Ryan S. Roark,Rebecca S. Rudicell,Stephen D. Schmidt,Daniel J. Sheward,Cinque Soto,Constantinos Kurt Wibmer,Yongping Yang,Zhenhai Zhang,Nisc Comparative Sequencing,James C. Mullikin,James M. Binley,Rogier W. Sanders,Ian A. Wilson,John P. Moore,Andrew B. Ward,George Georgiou,Carolyn Williamson,Salim S. Abdool Karim,Lynn Morris,Peter D. Kwong,Lawrence Shapiro,John R. Mascola +45 more
TL;DR: HIV-1 V1V2-directed neutralizing antibodies can develop relatively rapidly through initial selection of B cells with a long CDR H3, and limited subsequent somatic hypermutation, and provide important insights relevant to HIV-1 vaccine development.
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Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies.
TL;DR: Key ADE mechanisms are described and mitigation strategies for SARS-CoV-2 vaccines and therapies in development are discussed and recently published data is outlined to evaluate the risks and opportunities for antibody-based protection against Sars-Cov-2.
Journal ArticleDOI
High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire.
Brandon J. DeKosky,Gregory C. Ippolito,Ryan Deschner,Jason J. Lavinder,Yariv Wine,Brandon M. Rawlings,Navin Varadarajan,Claudia Giesecke,Thomas Dörner,Sarah F. Andrews,Patrick C. Wilson,Scott Patrick Hunicke-Smith,C. Grant Willson,Andrew D. Ellington,George Georgiou +14 more
TL;DR: The fidelity of VH:VL pairs identified by this approach were validated and the method was used to sequence the repertoire of three human cell subsets—peripheral blood IgG+ B cells, peripheral plasmablasts isolated after tetanus toxoid immunization and memory B cells isolated after seasonal influenza vaccination.
Journal ArticleDOI
In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire
Brandon J. DeKosky,Takaaki Kojima,Alexa Rodin,Wissam Charab,Gregory C. Ippolito,Andrew D. Ellington,George Georgiou +6 more
TL;DR: A low-cost, single-cell, emulsion-based technology for sequencing antibody VH-VL repertoires from >2 × 106 B cells per experiment with demonstrated pairing precision >97%.
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Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination
Jiwon Lee,Daniel R. Boutz,Veronika Chromikova,M. Gordon Joyce,Christopher Vollmers,Kwanyee Leung,Andrew P. Horton,Brandon J. DeKosky,Brandon J. DeKosky,Chang-Han Lee,Jason J. Lavinder,Ellen M. Murrin,Constantine Chrysostomou,Kam Hon Hoi,Yaroslav Tsybovsky,Paul V. Thomas,Aliaksandr Druz,Baoshan Zhang,Yi Zhang,Lingshu Wang,Wing Pui Kong,Daechan Park,Lyubov I. Popova,Lyubov I. Popova,Cornelia L. Dekker,Mark M. Davis,Chalise E. Carter,Ted M. Ross,Andrew D. Ellington,Patrick C. Wilson,Edward M. Marcotte,John R. Mascola,Gregory C. Ippolito,Florian Krammer,Stephen R. Quake,Peter D. Kwong,George Georgiou +36 more
TL;DR: High-resolution proteomics analysis of immunoglobulin coupled with high-throughput sequencing of transcripts encoding B cell receptors to quantitatively determine the antibody repertoire at the individual clonotype level in the sera of young adults before and after vaccination with trivalent seasonal influenza vaccine reveals unanticipated insights regarding the serological response to influenza vaccination.