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Yasumasa Yoshiyama
Researcher at Chiba University
Publications - 44
Citations - 4059
Yasumasa Yoshiyama is an academic researcher from Chiba University. The author has contributed to research in topics: Tauopathy & Neurodegeneration. The author has an hindex of 28, co-authored 43 publications receiving 3560 citations. Previous affiliations of Yasumasa Yoshiyama include University of Pennsylvania.
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Journal ArticleDOI
Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
Yasumasa Yoshiyama,Makoto Higuchi,Bin Zhang,Shu-Ming Huang,Nobuhisa Iwata,Takaomi C. Saido,Jun Maeda,Tetsuya Suhara,John Q. Trojanowski,Virginia M.-Y. Lee +9 more
TL;DR: In this paper, the authors studied wild-type and P301S mutant human tau transgenic (Tg) mice and found that tangle formation was preceded by microglial activation.
Journal ArticleDOI
Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy
Bin Zhang,Makoto Higuchi,Yasumasa Yoshiyama,Takeshi Ishihara,Mark S. Forman,Daniel Martinez,Sonali Joyce,John Q. Trojanowski,Virginia M.-Y. Lee +8 more
TL;DR: Data indicate that the R406W mutation causes reduced binding of this mutant tau to microtubules, resulting in slower axonal transport, which leads to increased accumulation and reduced solubility of RW tau in an age-dependent manner, culminating in the formation of filamentous intraneuronal tau aggregates similar to that observed in tauopathy patients.
Journal ArticleDOI
Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice.
Takeshi Ishihara,Bin Zhang,Makoto Higuchi,Yasumasa Yoshiyama,John Q. Trojanowski,Virginia M.-Y. Lee +5 more
TL;DR: In conclusion, overexpression of the smallest human brain tau isoform resulted in late onset and age-dependent formation of congophilic tau inclusions with properties similar to those in the tangles of human tauopathies, thereby implicating aging in the pathogenesis of fibrous tAU inclusions.
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Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies
Maiko Ono,Maiko Ono,Naruhiko Sahara,Katsushi Kumata,Bin Ji,Ruiqing Ni,Shunsuke Koga,Dennis W. Dickson,John Q. Trojanowski,Virginia M.-Y. Lee,Mari Yoshida,Isao Hozumi,Yasumasa Yoshiyama,John C. van Swieten,Agneta Nordberg,Tetsuya Suhara,Ming-Rong Zhang,Makoto Higuchi +17 more
TL;DR: Compared binding of tau positron emission tomography ligands, PBB3 and AV-1451, by fluorescence, autoradiography and homogenate binding assays with homologous and heterologous blockades using tauopathy brain samples indicate distinct selectivity of P BB3 compared to AV- 1451 for diverse tau fibril strains.
Journal ArticleDOI
Enhanced Neurofibrillary Tangle Formation, Cerebral Atrophy, and Cognitive Deficits Induced by Repetitive Mild Brain Injury in a Transgenic Tauopathy Mouse Model
Yasumasa Yoshiyama,Kunihiro Uryu,Makoto Higuchi,Luca Longhi,Rachel C. Hoover,Scott Fujimoto,Tracy K. McIntosh,Virginia M.-Y. Lee,John Q. Trojanowski +8 more
TL;DR: Researchers report studies of the effects of mrTBI on AD-like tau pathologies in Tg mice expressing the shortest human tau isoform (T44) subjected to mmTBI, causing brain concussion without structural brain damage to simulate injuries linked to DP.