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Yigael Finkel
Researcher at Boston Children's Hospital
Publications - 46
Citations - 8021
Yigael Finkel is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Inflammatory bowel disease & Crohn's disease. The author has an hindex of 20, co-authored 46 publications receiving 7745 citations.
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Journal ArticleDOI
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Jean-Pierre Hugot,Mathias Chamaillard,Mathias Chamaillard,Habib Zouali,Suzanne Lesage,Jean-Pierre Cézard,Jacques Belaiche,Sven Almer,Curt Tysk,Colm O'Morain,Miquel A. Gassull,Vibeke Binder,Yigael Finkel,Antoine Cortot,Robert Modigliani,Pierre Laurent-Puig,C. Gower-Rousseau,J. Macry,Jean-Frederic Colombel,Mourad Sahbatou,Gilles Thomas,Gilles Thomas +21 more
TL;DR: It is suggested that the NOD2 gene product confers susceptibility to Crohn's disease by altering the recognition of these components and/or by over-activating NF-kB in monocytes, thus documenting a molecular model for the pathogenic mechanism of Crohn’s disease that can now be further investigated.
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CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease.
Suzanne Lesage,Habib Zouali,Jean-Pierre Cézard,Jean-Frederic Colombel,Jacques Belaiche,Sven Almer,Curt Tysk,Colm O'Morain,Miquel A. Gassull,Vibeke Binder,Yigael Finkel,Robert Modigliani,Corinne Gower-Rousseau,J. Macry,Françoise Merlin,Mathias Chamaillard,Anne-Sophie Jannot,Gilles Thomas,Jean-Pierre Hugot +18 more
TL;DR: The mutational analyses of CARD15 in 453 patients with CD, including 166 sporadic and 287 familial cases, 159 patients with ulcerative colitis (UC), and 103 healthy control subjects provide tools for a DNA-based test of susceptibility and for genetic counseling in inflammatory bowel disease.
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Changing pattern of paediatric inflammatory bowel disease in northern Stockholm 1990-2001.
TL;DR: The results suggest a shift in presentation and diagnosis from UC towards CD, but also a net increase in IBD.
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Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease
Yukihide Momozawa,Myriam Mni,Kayo Nakamura,Wouter Coppieters,Sven Almer,Leila Amininejad,Isabelle Cleynen,Jean-Frederic Colombel,Peter De Rijk,Olivier Dewit,Yigael Finkel,Miquel A. Gassull,Dirk Goossens,Debby Laukens,Marc Lémann,Cécile Libioulle,Colm O'Morain,Catherine Reenaers,Paul Rutgeerts,Curt Tysk,Diana Zelenika,Mark Lathrop,Jurgen Del-Favero,Jean-Pierre Hugot,Martine De Vos,Denis Franchimont,Severine Vermeire,Edouard Louis,Michel Georges +28 more
TL;DR: The use of high-throughput resequencing of DNA pools to search for rare coding variants influencing susceptibility to Crohn's disease in 63 GWAS-identified positional candidate genes is described, finding low frequency coding variants conferring protection against inflammatory bowel disease in IL23R.
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Colorectal inflammation is well predicted by fecal calprotectin in children with gastrointestinal symptoms.
TL;DR: Fecal calprotectin can be used to select patients who should undergo diagnostic colonoscopy for investigation of colorectal inflammation, including inflammatory bowel disease.