Yingzhou Hu

TL;DR: Detailed genotypes and phenotypes of TALEN-edited MECP2 mutant cynomolgus monkeys serving as a model for a neurodevelopmental disorder, Rett syndrome (RTT), are reported, suggesting that gene-edited RTT founder monkeys would be of value for disease mechanistic studies as well as development of potential therapeutic interventions for RTT.

TL;DR: In this article, the authors used an adeno-associated virus serotype 9 (AAV9)-delivered CRISPR/Cas9 system to directly co-edit PINK1 and DJ-1 genes in the substantia nigras (SNs) of two monkey groups: an old group and a middle-aged group.

TL;DR: A cynomolgus monkey with naturally occurring Parkinson’s disease Hao Li 1 and Ling-Yan Su1.

TL;DR: It is found that some transplanted cells differentiated into mature neurons and formed synaptic input/output connections with the host neurons, and multichannel recordings indicated IC specific tuning activities in response to auditory stimulation.

TL;DR: This novel approach provides an edge in evaluating the mechanisms of PD pathology associated with environmental toxins and novel treatment approaches as the formula developed provides a "map" to control and predict the modeling processes.