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Yu Kato
Researcher at La Jolla Institute for Allergy and Immunology
Publications - 24
Citations - 5361
Yu Kato is an academic researcher from La Jolla Institute for Allergy and Immunology. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 13, co-authored 22 publications receiving 2445 citations. Previous affiliations of Yu Kato include Scripps Research Institute & University of Melbourne.
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Journal ArticleDOI
Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection.
Jennifer M. Dan,Jennifer M. Dan,Jose Mateus,Yu Kato,Kathryn M. Hastie,Esther Dawen Yu,Caterina E. Faliti,Alba Grifoni,Sydney I. Ramirez,Sydney I. Ramirez,Sonya Haupt,April Frazier,Catherine Nakao,Vamseedhar Rayaprolu,Stephen A. Rawlings,Bjoern Peters,Bjoern Peters,Florian Krammer,Viviana Simon,Erica Ollmann Saphire,Erica Ollmann Saphire,Davey M. Smith,Daniela Weiskopf,Alessandro Sette,Alessandro Sette,Shane Crotty,Shane Crotty +26 more
TL;DR: This article analyzed multiple compartments of circulating immune memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 254 samples from 188 COVID-19 cases, including 43 samples at ≥ 6 months after infection.
Journal ArticleDOI
Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity.
Carolyn Rydyznski Moderbacher,Sydney I. Ramirez,Sydney I. Ramirez,Jennifer M. Dan,Jennifer M. Dan,Alba Grifoni,Kathryn M. Hastie,Daniela Weiskopf,Simon Bélanger,Robert K. Abbott,Christina K. Kim,Jinyong Choi,Yu Kato,Eleanor G. Crotty,Cheryl Kim,Stephen A. Rawlings,Jose Mateus,Longping V. Tse,April Frazier,Ralph S. Baric,Bjoern Peters,Jason A. Greenbaum,Erica Ollmann Saphire,Erica Ollmann Saphire,Davey M. Smith,Alessandro Sette,Alessandro Sette,Shane Crotty,Shane Crotty +28 more
TL;DR: A combined examination of all three branches of adaptive immunity at the level of SARS-CoV-2-specific CD4+ and CD8+ T cell and neutralizing antibody responses in acute and convalescent subjects suggested roles for both CD4 plus T cells in protective immunity in COVID-19.
Journal ArticleDOI
Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity. Moderbacher et al.
Carolyn Rydyznski Moderbacher,Sydney I. Ramirez,Jennifer M. Dan,Alba Grifoni,Kathryn M. Hastie,Daniela Weiskopf,Simon Bélanger,Robert K. Abbott,Christina K. Kim,Jinyong Choi,Yu Kato,Eleanor G. Crotty,Cheryl Kim,Stephen A. Rawlings,Jose Mateus,Longping V. Tse,April Frazier,Ralph S. Baric,Bjoern Peters,Jason A. Greenbaum,Erica Ollmann Saphire,Davey M. Smith,Alessandro Sette,Shane Crotty +23 more
Journal ArticleDOI
Liver-Resident Memory CD8 + T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection.
Daniel Fernandez-Ruiz,Wei Yi Ng,Wei Yi Ng,Lauren E. Holz,Joel Z. Ma,Ali Zaid,Yik Chun Wong,Lei Shong Lau,Vanessa Mollard,Anton Cozijnsen,Nicholas Collins,Jessica Li,Jessica Li,Gayle M. Davey,Yu Kato,Sapna Devi,Roghieh Skandari,Michael Pauley,Jonathan H. Manton,Dale I. Godfrey,Asolina Braun,Szun S. Tay,Peck Szee Tan,Peck Szee Tan,David G. Bowen,Friedrich Koch-Nolte,Björn Rissiek,Francis R. Carbone,Brendan S. Crabb,Mireille H. Lahoud,Mireille H. Lahoud,Ian A. Cockburn,Scott N. Mueller,Patrick Bertolino,Geoffrey I. McFadden,Irina Caminschi,Irina Caminschi,William R. Heath +37 more
TL;DR: It is shown that by combining dendritic cell-targeted priming with liver inflammation and antigen recognition on hepatocytes, high frequencies of Trm cells could be induced and these cells were essential for protection against malaria sporozoite challenge.
Journal ArticleDOI
Targeting Antigen to Mouse Dendritic Cells via Clec9A Induces Potent CD4 T Cell Responses Biased toward a Follicular Helper Phenotype
Mireille H. Lahoud,Fatma Ahmet,Susie Kitsoulis,Soo San Wan,David Vremec,Chin-Nien Lee,Belinda Phipson,Wei Shi,Wei Shi,Gordon K. Smyth,Andrew M. Lew,Yu Kato,Scott N. Mueller,Gayle M. Davey,William R. Heath,Ken Shortman,Ken Shortman,Irina Caminschi,Irina Caminschi +18 more
TL;DR: Potent humoral immunity was a result of the highly specific expression of Clec9A on DCs, which allowed longer residence of targeting Abs in the bloodstream, prolonged DC Ag presentation, and extended CD4 T cell proliferation, all of which drove highly efficient development of follicular helper T cells.