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Yunwen Hu
Researcher at Fudan University
Publications - 86
Citations - 5095
Yunwen Hu is an academic researcher from Fudan University. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 29, co-authored 85 publications receiving 4575 citations. Previous affiliations of Yunwen Hu include Fudan University Shanghai Medical College.
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Journal ArticleDOI
Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus
Rongbao Gao,Bin Cao,Yunwen Hu,Zijian Feng,Dayan Wang,Wanfu Hu,Jian Chen,Zhijun Jie,Haibo Qiu,Ke Xu,Xuewei Xu,Hongzhou Lu,Wenfei Zhu,Zhancheng Gao,Nijuan Xiang,Yinzhong Shen,Zebao He,Y. Gu,Zhiyong Zhang,Yi Yang,Xiang Zhao,Lei Zhou,Xiaodan Li,Shumei Zou,Ye Zhang,Xiyan Li,Lei Yang,Junfeng Guo,Jie Dong,Qun Li,Libo Dong,Yun Zhu,Tian Bai,Shiwen Wang,Pei Hao,Weizhong Yang,Yanping Zhang,Jun Han,Hongjie Yu,Dexin Li,George F. Gao,Guizhen Wu,Yu Wang,Zhenghong Yuan,Yuelong Shu +44 more
TL;DR: Novel reassortant H7N9 viruses were associated with severe and fatal respiratory disease in three patients, and all three patients died.
Journal ArticleDOI
Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance
Yunwen Hu,Shuihua Lu,Zhigang Song,Wei Wang,Pei Hao,Pei Hao,Jianhua Li,Xiaonan Zhang,Hui-Ling Yen,Bisheng Shi,Tao Li,Wencai Guan,Lei Xu,Yi Liu,Sen Wang,Xiaoling Zhang,Di Tian,Zhaoqin Zhu,Jing He,Kai Huang,Huijie Chen,Lulu Zheng,Xuan Li,Jie Ping,Jie Ping,Bin Kang,Xiuhong Xi,Li-jun Zha,Yixue Li,Zhiyong Zhang,Malik Peiris,Zhenghong Yuan +31 more
TL;DR: The emergence of antiviral resistance in A/H7N9 viruses, especially in patients receiving corticosteroid therapy, is concerning, needs to be closely monitored, and considered in pandemic preparedness planning.
Journal ArticleDOI
Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8⁺ T cells.
Zhongfang Wang,Yanmin Wan,Chenli Qiu,Sergio M. Quiñones-Parra,Zhaoqin Zhu,Liyen Loh,Di Tian,Yanqin Ren,Yunwen Hu,Xiaoyan Zhang,Paul G. Thomas,Michael Inouye,Peter C. Doherty,Katherine Kedzierska,Jianqing Xu +14 more
TL;DR: In this paper, the authors dissect the kinetic emergence of different effector mechanisms across the spectrum of H7N9 disease and recovery and find that a diversity of response mechanisms contribute to resolution and survival.
Journal ArticleDOI
HBsAg inhibits TLR9-mediated activation and IFN-α production in plasmacytoid dendritic cells
Yongfen Xu,Yunwen Hu,Yunwen Hu,Bisheng Shi,Bisheng Shi,Xiaonan Zhang,Jiefei Wang,Zhanqing Zhang,Fang Shen,Qin Zhang,Shuhui Sun,Zhenghong Yuan,Zhenghong Yuan +12 more
TL;DR: It is suggested that HBsAg may directly interfere with the function of pDC throughHBsAg-mediated upregulation of SOCS-1 expression and BDCA-2 ligation, which could partially explain how HBV evades the immune system to establish a persistent infection.
Journal ArticleDOI
Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients
Zhiao Chen,Yuming Cheng,Yongfen Xu,Jing Liao,Xiaonan Zhang,Yunwen Hu,Qin Zhang,Jiefei Wang,Zhanqing Zhang,Fang Shen,Zhenghong Yuan +10 more
TL;DR: This study reveals a possible interaction between HBsAg, TLR signaling and the innate immune response, which may partially explain the mechanism of HBV infection induced immuno-tolerance.