Yusuke Ito

TL;DR: ptive activation of peroxisome proliferator-activated receptor (PPAR)alpha, PPARgamma, and both of them in combination in obese diabetic KKAy mice markedly improved insulin sensitivity and dual activation of PPARalpha and -gamma enhances the action of adip onectin by increasing both adiponectin and AdipoRs, which can result in the amelioration of obesity-induced insulin resistance.

TL;DR: Data indicate that the cleavage of adiponectin by leukocyte elastase secreted from activated monocytes and/or neutrophils could be a candidate for the mechanism of the generation of the globular fragment of adip onectin.

TL;DR: It is shown that the protein encoded by ORE20/PHO36 (YOL002c), a seven transmembrane domain receptor-like polypeptide that regulates lipid and phosphate metabolism, is an osmotin binding plasma membrane protein that is required for full sensitivity to osmoton.

TL;DR: Observations suggest that "insulin-stimulated Akt activity in adipocytes" may play an important role in the regulation of adiponectin secretion.

TL;DR: The hypothesis that leptin regulates adipocyte size by altering expression patterns of DGAT via central nervous system to determine the levels of triglyceride synthesis is proposed.