Zlatan Mujagic

TL;DR: Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based cohort shows relations between the microbiome and 126 exogenous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smoking categories, and 60 dietary factors, and an important step toward a better understanding of environment-diet-microbe-host interactions.

TL;DR: The differences between PPI users and non-users observed in this study are consistently associated with changes towards a less healthy gut microbiome, in line with known changes that predispose to C. difficile infections.

TL;DR: Evidence of a causal effect of the gut microbiome on metabolic traits is shown and the use of MR is supported as a means to elucidate causal relationships from microbiome-wide association findings.

TL;DR: The results demonstrate the importance of understanding host–microbe interactions to gain better insight into human health and demonstrate the influence of host genetics on microbial species, pathways and gene ontology categories on the basis of metagenomic sequencing in 1,514 subjects.

TL;DR: The impact of 41 commonly used medications on the taxonomic structures, metabolic potential and resistome of the gut microbiome is studied, underscoring the importance of correcting for multiple drug use in microbiome studies.