ACADIA Pharmaceuticals Inc.

About: ACADIA Pharmaceuticals Inc. is a company organization based out in San Diego, California, United States. It is known for research contribution in the topics: Pimavanserin & Receptor. The organization has 260 authors who have published 276 publications receiving 8418 citations.

Pimavanserin in Alzheimer's Disease Psychosis: Efficacy in Patients with More Pronounced Psychotic Symptoms.

Abstract: Pimavanserin is a 5-HT2A receptor inverse agonist/antagonist and is approved in the United States for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis Evaluate the efficacy of pimavanserin on symptoms of psychosis in patients with Alzheimer’s disease (AD) Randomized, double-blind, placebo-controlled trial Nursing home residents Patients with AD psychosis Pimavanserin 34 mg or placebo daily for 12 weeks The primary endpoint was mean change from baseline at Week 6 on the Neuropsychiatric Inventory-Nursing Home Version psychosis score (NPI-NH-PS) In the prespecified subgroup analysis, the mean change in NPI-NH-PS and the responder rates among those with baseline NPI-NH-PS ≥12 were evaluated Of 181 patients randomized (n=90 pimavanserin; n=91 placebo), 57 had baseline NPI-NH-PS ≥12 (n=27 pimavanserin; n=30 placebo) In this severe subgroup, large treatment effects were observed (delta=-443, Cohen’s d=-073, p=0011), and ≥30% improvement was 889% vs 433% (p<0001) and ≥50% improvement was 778% vs 433% (p=0008) for pimavanserin and placebo, respectively The rate of adverse events (AEs) in the severe subgroup was similar between treatment groups, and urinary tract infection, fall, and agitation were most frequent Serious AEs was similar with pimavanserin (179%) and placebo (167%) with fewer discontinuations due to AEs with pimavanserin (71%) compared to placebo (100%) Minimal change from baseline occurred for the mean MMSE score over 12 weeks Pimavanserin demonstrated significant efficacy in AD psychosis in patients with higher baseline severity of psychotic symptoms (NPI-NH-PS ≥12) Treatment with pimavanserin showed an acceptable tolerability profile

Tetrahydroquinoline analogues as muscarinic agonists

Abstract: The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.