American University in Cairo

About: American University in Cairo is a education organization based out in Cairo, Egypt. It is known for research contribution in the topics: Population & Context (language use). The organization has 2472 authors who have published 5339 publications receiving 73741 citations.

The ambiguity of participation: a qualified defence of participatory development

Abstract: This paper examines some of the critiques addressed to participatory development by critics such as Cooke and Kothari. It argues that criticisms of participation's theoretical coherence and of its lapse into a routinised praxis largely arise from an unavoidable ambiguity that is inherent in the concept of participation, this being the means/end ambiguity. Participation must function as a means because any development project must produce some outputs (therefore participation is seen as a means to achieve such outputs), but it must also function as an end inasmuch as empowerment is viewed as a necessary outcome. This ambiguity becomes contradictory when emphasis is laid on participation as a means at the expense of participation as an end. The article proposes ways of re‐emphasising the element of empowerment so that participation may function as an emancipatory strategy.

Nanodiagnostics: A New Frontier for Clinical Laboratory Medicine

Abstract: Background: The use of nanotechnologies for diagnostic applications shows great promise to meet the rigorous demands of the clinical laboratory for sensitivity and cost-effectiveness. New nanodiagnostic tools include quantum dots (QDs), gold nanoparticles, and cantilevers. QDs, which are the most promising nanostructures for diagnostic applications, are semiconductor nanocrystals characterized by high photostability, single-wavelength excitation, and size-tunable emission. QDs and magnetic nanoparticles can be used for barcoding of specific analytes. Gold and magnetic nanoparticles are key components of the bio-barcode assay, which has been proposed as a future alternative to the PCR. Methods: We examined articles published over the past 10 years investigating the use of QDs, gold nanoparticles, cantilevers, and other nanotechnologies in promising diagnostic applications. Results: Several nanodiagnostic assays have been developed, including a QD-based assay capable of detecting biotinylated prostate-specific antigen (PSA) at 0.38 ng/L, a bio-barcode assay capable of detecting 30 amol/L PSA in a 10-μL sample, and another able to detect 50 molecules of the Alzheimer marker amyloid β-derived diffusible ligand in 10 μL of cerebrospinal fluid. Conclusions: Nanodiagnostics promise increased sensitivity, multiplexing capabilities, and reduced cost for many diagnostic applications as well as intracellular imaging. Further work is needed to fully optimize these diagnostic nanotechnologies for clinical laboratory setting and to address the potential health and environmental risks related to QDs.