Atlantic Health System

About: Atlantic Health System is a healthcare organization based out in Morristown, New Jersey, United States. It is known for research contribution in the topics: Health care & Medicine. The organization has 277 authors who have published 299 publications receiving 6594 citations.

Management of relapsed and refractory childhood acute promyelocytic leukaemia: recommendations from an international expert panel.

Abstract: Oussama Abla, Matthew A. Kutny, Anna Maria Testi, James H. Feusner, Ursula Creutzig, John Gregory Jr, Brenda Gibson, Guy Leverger, Raul C. Ribeiro, Owen Smith, Franco Locatelli and Gertjan Kaspers Division of Hematology/Oncology, Department of Pediatrics, the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada, Department of Pediatrics, Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL, USA, Department of Cellular Biotechnologies and Haematology, Sapienza University of Rome, Rome, Italy, Division of Hematology/ Oncology, Children’s Hospital and Research Center Oakland, Oakland, CA, USA, Paediatric Haematology/Oncology, Hannover Medical School, Hannover, Germany, Atlantic Health System, Goryeb Children’s Hospital, Morristown, NJ, USA, Department of Haematology and Oncology, Royal Hospital for Children, Glasgow, UK, Haematology/Oncology, Hôpital Armand Trousseau, Paris, France, Department of Oncology, Division of Leukemia/Lymphoma, St. Jude Children’s Research Hospital, Memphis, TN, USA, Department of Haematology/Oncology, Our Lady’s Children’s Hospital, Dublin, Ireland, Department of Paediatric Haematology and Oncology, IRCCS Ospedale Pediatrico Bambino Ges u, Rome, University of Pavia, Pavia, Italy, Paediatric Oncology, VU University Medical Centre, Amsterdam and Academy of Princess Máxima Centre for Paediatric Oncology, Utrecht, The Netherlands

Traumatic brain injuries and computed tomography use in pediatric sports participants.

Abstract: Background Childhood sports-related head trauma is common, frequently leading to emergency department (ED) visits. We describe the spectrum of these injuries and trends in computed tomography (CT) use in the Pediatric Emergency Care Applied Research Network. Methods This was a secondary analysis of a large prospective cohort of children with head trauma in 25 Pediatric Emergency Care Applied Research Network EDs between 2004 and 2006. We described and compared children 5 to 18 years old by CT rate, traumatic brain injury (TBI) on CT, and clinically important TBI (ciTBI). We used multi-variable logistic regression to compare CT rates, adjusting for clinical severity. Outcomes included frequency of CT, TBIs on CT, and ciTBIs (defined by [ a ] death, [ b ] neurosurgery, [ c ] intubation >24 hours, or [ d ] hospitalization for ≥2 nights). Findings A total of 3289 (14%) of 23082 children had sports-related head trauma. Two percent had Glasgow Coma Scale scores less than 14. 53% received ED CTs, 4% had TBIs on CT, and 1% had ciTBIs. Equestrians had increased adjusted odds (1.8; 95% confidence interval [CI], 1.0-3.0]) of CTs; the rate of TBI on CT was 4% (95% CI, 3%-5%). Compared with team sports, snow (adjusted odds ratio, 4.1; 95% CI 1.5-11.4) and nonmotorized wheeled (adjusted odds ratio, 12.8; 95% CI, 5.5-32.4) sports had increased adjusted odds of ciTBIs. Conclusions Children with sports-related head trauma commonly undergo CT. Only 4% of those imaged had TBIs on CT. Clinically important TBIs occurred in 1%, with significant variation by sport. There is an opportunity for injury prevention efforts in high-risk sports and opportunities to reduce CT use in general by use of evidence-based prediction rules. What is known about this subject: Pediatric sports-related head injuries are a common and increasingly frequent ED presentation, as is the use of CT in their evaluation. Little is known about TBIs resulting from different types of sports activities in children. What this study adds to existing knowledge: This study broadens the understanding of the epidemiology of Pediatric TBIs resulting from different sports activities through a prospective assessment of frequency and severity of ciTBIs and ED CT use in a large cohort of head-injured children in a network of pediatric EDs.

Developmental regulation of the gut-liver (FGF19-CYP7A1) axis in neonates.

Abstract: Introduction: Fibroblast growth factor 19 (FGF19) is a gut-derived hormone that regulates the expression of CYP7A1, the rate-limiting enzyme in bile acid (BA) synthesis pathway. Dysregulati...