Bethesda Hospital

About: Bethesda Hospital is a healthcare organization based out in Ambur, Tamil Nadu, India. It is known for research contribution in the topics: Population & Helicobacter pylori. The organization has 386 authors who have published 472 publications receiving 15193 citations.

Surgical Treatment of Severe Hallux Abductovalgus With Dislocation of the First Metatarsophalangeal Joint: A Case Presentation and Surgical Technique.

Abstract: Severe hallux abductovalgus deformity with dislocation and contracture at the first metatarsophalangeal joint is difficult to manage, especially in the presence of concomitant, long-standing rheuma...

Mycoplasma pneumoniae carriage evades induction of protective mucosal antibodies.

Abstract: Mycoplasma pneumoniae is the most common bacterial cause of pneumonia in children hospitalised for community-acquired pneumonia. Prevention of infection by vaccines may be an important strategy in the presence of emerging macrolide resistant M. pneumoniae. However, knowledge of immune responses to M. pneumoniae is limited, complicating vaccine design. We therefore studied the antibody response during M. pneumoniae infection and asymptomatic carriage.In a nested case-control study (n=80) of M. pneumoniae carriers and matched controls we observed that carriage by M. pneumoniae does not lead to a rise in either mucosal or systemic M. pneumoniae-specific antibodies, even after months of persistent carriage. We replicated this finding in a second cohort (n=69) and also found that during M. pneumoniae community-acquired pneumonia, mucosal levels of M. pneumoniae-specific IgA and IgG did increase significantly. In vitro adhesion assays revealed that high levels of M. pneumoniae-specific antibodies in nasal secretions of paediatric patients prevented the adhesion of M. pneumoniae to respiratory epithelial cells.In conclusion, our study demonstrates that M. pneumoniae-specific mucosal antibodies protect against bacterial adhesion to respiratory epithelial cells and are induced only during M. pneumoniae infection and not during asymptomatic carriage. This is strikingly different from carriage with bacteria such as Streptococcus pneumoniae where mucosal antibodies are induced by bacterial carriage.

Risk factors of intracranial stenosis among older adults with acute ischemic stroke

Abstract: Intracranial large artery atherosclerosis is an important cause of stroke worldwide. Previous studies have shown that it is found more commonly in Asians. However, studies of intracranial stenosis in Indonesian stroke patients have been very few in number. The aim of this cross-sectional study was to determine the frequency and risk factors of intracranial stenosis in acute ischemic stroke. The data were obtained from 234 consecutive patients in the transcranial doppler (TCD) registry. Documentation of risk factors was performed systematically and for TCD sonography TD-DOP 9000 equipment with a 2-MHz probe was used for the examination of the intracranial circulation. The criteria of middle cerebral artery (MCA) stenosis used in this study were a peak systolic velocity (PSV) >140 cm/s or mean systolic velocity (MSV) >80 cm/s. For stenosis of the posterior circulation the criteria were PSV > 90 cm/s or MSV >60 cm/s. The data were obtained from 234 patients, and complete examinations were performed in 182 patients (77.7%). Ischemic stroke is the most common indication for performing TCD sonography. Stenosis was present in 38% of cases, with stenosis iof the anterior circulation being the more common. The most frequent risk factors were hypertension, dyslipidemia, and diabetes. Intracranial stenosis is common in stroke patients, in whom the risk factors are hypertension and diabetes.

Endoscopic surgery for female infertility: a review of current management.

Abstract: Disease or damage of the fallopian tube accounts for 25– 35% of reported cases of infertility. A spectrum of severity of tubal disease exists from peritubal adhesions, through damaged fimbriae and distorted anatomy to tubal occlusion, hydrosalpinges and abnormal tubal mucosa. The factors responsible for tubal disease are diverse and varied and include previous surgery, endometriosis and pelvic infection. Tubal disease increases the rates of ectopic pregnancy and also miscarriage, especially in the case of hydrosalpinges. Accepted treatment for tubal infertility includes tubal surgery, expectant management (no treatment) or in vitro fertilisation (IVF). Although IVF is often the first treatment of choice and has resulted in major advances in the management of infertility, tubal surgery has advantages, including the potential for prolonged restoration of fertility and, for some, overcoming the costs associated with IVF. Furthermore, it offers an approach to patients who may have religious or cultural beliefs that prohibit IVF. It also avoids the adverse outcomes of ovarian hyperstimulation syndrome (OHSS) and multiple pregnancy. Importantly, avoiding IVF also means avoids other significant adverse outcomes, such as fetal anomaly and imprinting disorders.