Institution
Castle Peak Hospital
Healthcare•Hong Kong, Hong Kong, China•
About: Castle Peak Hospital is a healthcare organization based out in Hong Kong, Hong Kong, China. It is known for research contribution in the topics: Schizophrenia & Anhedonia. The organization has 239 authors who have published 409 publications receiving 14472 citations.
Topics: Schizophrenia, Anhedonia, Population, Mental health, Schizotypy
Papers published on a yearly basis
Papers
More filters
••
TL;DR: Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
Abstract: Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.
6,809 citations
••
TL;DR: For the first time, specific loci that distinguish between BD and SCZ are discovered and polygenic components underlying multiple symptom dimensions are identified that point to the utility of genetics to inform symptomology and potential treatment.
569 citations
••
TL;DR: The current findings suggest that patients with schizophrenia have moderately to severely impaired perception of facial emotion.
Abstract: Research into facial emotion perception in schizophrenia has burgeoned over the past several decades. The evidence is mixed regarding whether patients with schizophrenia have a general facial emotion perception deficit (a deficit in facial emotion perception plus a more basic deficit in facial processing) or specific facial emotion perception deficits (deficits only in facial emotion perception tasks). A meta-analysis is conducted of 28 facial emotion perception studies that include control tasks. These studies use differential deficit designs to examine whether patients with schizophrenia demonstrate a general deficit or specific deficit in facial emotion perception. A significant mean effect size is found for total facial emotion perception (d=-0.85). Patients with schizophrenia demonstrate impaired ability to perform corresponding control tasks, and the mean effect size is -0.70. The current findings suggest that patients with schizophrenia have moderately to severely impaired perception of facial emotion.
206 citations
••
TL;DR: Novel evidence is offered that motivational deficits in MDD are correlated with depression severity and predicted by self-reported anhedonia, and reduced anticipatory and consummatory pleasure predicted decreased willingness to expend efforts to obtain rewards inMDD patients.
Abstract: Anhedonia is a hallmark symptom of major depressive disorder (MDD). Preliminary findings suggest that anhedonia is characterized by reduced reward anticipation and motivation of obtaining reward. However, relatively little is known about reward-based decision-making in depression. We tested the hypothesis that anhedonia in MDD may reflect specific impairments in motivation on reward-based decision-making and the deficits might be associated with depressive symptoms severity. In study 1, individuals with and without depressive symptoms performed the modified version of the Effort Expenditure for Rewards Task (EEfRT), a behavioral measure of cost/benefit decision-making. In study 2, MDD patients, remitted MDD patients and healthy controls were recruited for the same procedures. We found evidence for decreased willingness to make effort for rewards among individuals with subsyndromal depression; the effect was amplified in MDD patients, but dissipated in patients with remitted depression. We also found that reduced anticipatory and consummatory pleasure predicted decreased willingness to expend efforts to obtain rewards in MDD patients. For individuals with subsyndromal depression, the impairments were correlated with anticipatory anhedonia but not consummatory anhedonia. These data offer novel evidence that motivational deficits in MDD are correlated with depression severity and predicted by self-reported anhedonia.
200 citations
••
Molde University College1, North Carolina State University2, University of South Florida3, University of Barcelona4, University of New South Wales5, Centre for Mental Health6, National University of La Plata7, Universidad Autónoma de Yucatán8, Karolinska Institutet9, Castle Peak Hospital10, University of Southern Denmark11, University of Mons12, Simon Fraser University13, University of Mainz14, Maastricht University15, University of Konstanz16
TL;DR: It is suggested that violence risk assessment is a global phenomenon, as is the use of instruments to assist in this task, and improved feedback following risk assessments and the development of risk management plans could improve the efficacy of health services.
Abstract: Mental health professionals are routinely called upon to assess the risk of violence presented by their patients. Prior surveys of risk assessment methods have been largely circumscribed to individual countries and have not compared the practices of different professional disciplines. Therefore, a Web-based survey was developed to examine methods of violence risk assessment across six continents, and to compare the perceived utility of these methods by psychologists, psychiatrists, and nurses. The survey was translated into nine languages and distributed to members of 59 national and international organizations. Surveys were completed by 2135 respondents from 44 countries. Respondents in all six continents reported using instruments to assess, manage, and monitor violence risk, with over half of risk assessments in the past 12 months conducted using such an instrument. Respondents in Asia and South America reported conducting fewer structured assessments, and psychologists reported using instruments more ...
186 citations
Authors
Showing all 240 results
Name | H-index | Papers | Citations |
---|---|---|---|
Eric F.C. Cheung | 35 | 216 | 10405 |
Wai Chi Chan | 24 | 79 | 1699 |
Simon S.Y. Lui | 24 | 157 | 1822 |
Yoke Lin Fung | 24 | 88 | 1981 |
Bacon F.L. Ng | 14 | 42 | 905 |
Steve Tso | 13 | 19 | 777 |
Allen T C Lee | 11 | 28 | 608 |
S. W. Li | 10 | 15 | 519 |
Jolene Mui | 9 | 12 | 188 |
Karen S. Y. Hung | 9 | 13 | 214 |
Eric Yat Wo Cheung | 8 | 11 | 180 |
William W.H. Chui | 7 | 13 | 137 |
Karen K. Y. Ho | 7 | 10 | 159 |
Ming Lam | 7 | 14 | 244 |
Bonnie W.M. Siu | 7 | 20 | 246 |