Institution
Ghent University
Education•Ghent, Belgium•
About: Ghent University is a education organization based out in Ghent, Belgium. It is known for research contribution in the topics: Population & Context (language use). The organization has 36170 authors who have published 111042 publications receiving 3774501 citations. The organization is also known as: UGent & University of Ghent.
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TL;DR: It is shown that HDM inhalation leads to the TLR4/MyD88-dependent recruitment of IL-4 competent basophils and eosinophils, and of inflammatory DCs to the draining mediastinal nodes, and a model whereby DCs initiate and basophil amplify Th2 immunity to HDM allergen is favored.
Abstract: It is unclear how Th2 immunity is induced in response to allergens like house dust mite (HDM). Here, we show that HDM inhalation leads to the TLR4/MyD88-dependent recruitment of IL-4 competent basophils and eosinophils, and of inflammatory DCs to the draining mediastinal nodes. Depletion of basophils only partially reduced Th2 immunity, and depletion of eosinophils had no effect on the Th2 response. Basophils did not take up inhaled antigen, present it to T cells, or express antigen presentation machinery, whereas a population of FceRI+ DCs readily did. Inflammatory DCs were necessary and sufficient for induction of Th2 immunity and features of asthma, whereas basophils were not required. We favor a model whereby DCs initiate and basophils amplify Th2 immunity to HDM allergen.
582 citations
TL;DR: A review regarding the assessment of physical activity and fitness andCardio-pulmonary exercise testing is a well-established procedure that provides a wealth of clinically diagnostic and prognostic information.
Abstract: Regular aerobic physical activity (PA) increases exercise capacity and physical fitness (PF), which can lead to many health benefits. Accurate quantification of PA and PF becomes essential in terms of health outcome and effectiveness of intervention programmes. In this manuscript we present a review
582 citations
TL;DR: In this review,Biofloc technology is a technique of enhancing water quality in aquaculture through balancing carbon and nitrogen in the system, with the added value of producing proteinaceous feed in situ.
582 citations
TL;DR: The clinical and laboratory parameters for diagnosing biofilm infections are outlined based on the patient's history, signs and symptoms, microscopic findings, culture-based or culture-independent diagnostic techniques and specific immune responses to identify microorganisms known to causeBiofilm infections.
581 citations
TL;DR: The significance of mitochondrial DAMPs is highlighted and their contribution to inflammation and development of human pathologies is discussed.
581 citations
Authors
Showing all 36585 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Stephen V. Faraone | 188 | 1427 | 140298 |
| Peter Carmeliet | 164 | 844 | 122918 |
| Monique M.B. Breteler | 159 | 546 | 93762 |
| Dirk Inzé | 149 | 647 | 74468 |
| Rajesh Kumar | 149 | 4439 | 140830 |
| Vishva M. Dixit | 145 | 355 | 96471 |
| Ruth J. F. Loos | 142 | 647 | 92485 |
| Martin Grunewald | 140 | 1575 | 126911 |
| Willy Verstraete | 139 | 920 | 76659 |
| Barbara Clerbaux | 138 | 1394 | 96447 |
| Peter Vandenabeele | 135 | 729 | 81692 |
| Michael Tytgat | 134 | 1449 | 94133 |
| Pascal Vanlaer | 133 | 1270 | 91850 |
| Filip Moortgat | 132 | 1118 | 97714 |
| Emelia J. Benjamin | 131 | 640 | 99972 |