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Harvard University

EducationCambridge, Massachusetts, United States
About: Harvard University is a(n) education organization based out in Cambridge, Massachusetts, United States. It is known for research contribution in the topic(s): Population & Cancer. The organization has 208150 authors who have published 530388 publication(s) receiving 38152182 citation(s). The organization is also known as: Harvard & University of Harvard.
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01 Jan 1956-
TL;DR: The theory provides us with a yardstick for calibrating the authors' stimulus materials and for measuring the performance of their subjects, and the concepts and measures provided by the theory provide a quantitative way of getting at some of these questions.
Abstract: First, the span of absolute judgment and the span of immediate memory impose severe limitations on the amount of information that we are able to receive, process, and remember. By organizing the stimulus input simultaneously into several dimensions and successively into a sequence or chunks, we manage to break (or at least stretch) this informational bottleneck. Second, the process of recoding is a very important one in human psychology and deserves much more explicit attention than it has received. In particular, the kind of linguistic recoding that people do seems to me to be the very lifeblood of the thought processes. Recoding procedures are a constant concern to clinicians, social psychologists, linguists, and anthropologists and yet, probably because recoding is less accessible to experimental manipulation than nonsense syllables or T mazes, the traditional experimental psychologist has contributed little or nothing to their analysis. Nevertheless, experimental techniques can be used, methods of recoding can be specified, behavioral indicants can be found. And I anticipate that we will find a very orderly set of relations describing what now seems an uncharted wilderness of individual differences. Third, the concepts and measures provided by the theory of information provide a quantitative way of getting at some of these questions. The theory provides us with a yardstick for calibrating our stimulus materials and for measuring the performance of our subjects. In the interests of communication I have suppressed the technical details of information measurement and have tried to express the ideas in more familiar terms; I hope this paraphrase will not lead you to think they are not useful in research. Informational concepts have already proved valuable in the study of discrimination and of language; they promise a great deal in the study of learning and memory; and it has even been proposed that they can be useful in the study of concept formation. A lot of questions that seemed fruitless twenty or thirty years ago may now be worth another look. In fact, I feel that my story here must stop just as it begins to get really interesting. And finally, what about the magical number seven? What about the seven wonders of the world, the seven seas, the seven deadly sins, the seven daughters of Atlas in the Pleiades, the seven ages of man, the seven levels of hell, the seven primary colors, the seven notes of the musical scale, and the seven days of the week? What about the seven-point rating scale, the seven categories for absolute judgment, the seven objects in the span of attention, and the seven digits in the span of immediate memory? For the present I propose to withhold judgment. Perhaps there is something deep and profound behind all these sevens, something just calling out for us to discover it. But I suspect that it is only a pernicious, Pythagorean coincidence.

16,021 citations

Journal ArticleDOI
Abstract: We present spectral and photometric observations of 10 Type Ia supernovae (SNe Ia) in the redshift range 0.16 " z " 0.62. The luminosity distances of these objects are determined by methods that employ relations between SN Ia luminosity and light curve shape. Combined with previous data from our High-z Supernova Search Team and recent results by Riess et al., this expanded set of 16 high-redshift supernovae and a set of 34 nearby supernovae are used to place constraints on the following cosmo- logical parameters: the Hubble constant the mass density the cosmological constant (i.e., the (H 0 ), () M ), vacuum energy density, the deceleration parameter and the dynamical age of the universe ) " ), (q 0 ), ) M \ 1) methods. We estimate the dynamical age of the universe to be 14.2 ^ 1.7 Gyr including systematic uncer- tainties in the current Cepheid distance scale. We estimate the likely e†ect of several sources of system- atic error, including progenitor and metallicity evolution, extinction, sample selection bias, local perturbations in the expansion rate, gravitational lensing, and sample contamination. Presently, none of these e†ects appear to reconcile the data with and ) " \ 0 q 0 " 0.

15,427 citations


Journal ArticleDOI
TL;DR: Lifetime prevalence estimates are higher in recent cohorts than in earlier cohorts and have fairly stable intercohort differences across the life course that vary in substantively plausible ways among sociodemographic subgroups.
Abstract: Context Little is known about lifetime prevalence or age of onset of DSM-IV disorders. Objective To estimate lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the recently completed National Comorbidity Survey Replication. Design and Setting Nationally representative face-to-face household survey conducted between February 2001 and April 2003 using the fully structured World Health Organization World Mental Health Survey version of the Composite International Diagnostic Interview. Participants Nine thousand two hundred eighty-two English-speaking respondents aged 18 years and older. Main Outcome Measures Lifetime DSM-IV anxiety, mood, impulse-control, and substance use disorders. Results Lifetime prevalence estimates are as follows: anxiety disorders, 28.8%; mood disorders, 20.8%; impulse-control disorders, 24.8%; substance use disorders, 14.6%; any disorder, 46.4%. Median age of onset is much earlier for anxiety (11 years) and impulse-control (11 years) disorders than for substance use (20 years) and mood (30 years) disorders. Half of all lifetime cases start by age 14 years and three fourths by age 24 years. Later onsets are mostly of comorbid conditions, with estimated lifetime risk of any disorder at age 75 years (50.8%) only slightly higher than observed lifetime prevalence (46.4%). Lifetime prevalence estimates are higher in recent cohorts than in earlier cohorts and have fairly stable intercohort differences across the life course that vary in substantively plausible ways among sociodemographic subgroups. Conclusions About half of Americans will meet the criteria for a DSM-IV disorder sometime in their life, with first onset usually in childhood or adolescence. Interventions aimed at prevention or early treatment need to focus on youth.

15,369 citations

Journal ArticleDOI
Abstract: We show that the large-N limits of certainconformal field theories in various dimensions includein their Hilbert space a sector describing supergravityon the product of anti-de Sitter spacetimes, spheres, and other compact manifolds. This is shown bytaking some branes in the full M/string theory and thentaking a low-energy limit where the field theory on thebrane decouples from the bulk. We observe that, in this limit, we can still trust thenear-horizon geometry for large N. The enhancedsupersymmetries of the near-horizon geometry correspondto the extra supersymmetry generators present in thesuperconformal group (as opposed to just the super-Poincaregroup). The 't Hooft limit of 3 + 1 N = 4 super-Yang–Mills at the conformal pointis shown to contain strings: they are IIB strings. Weconjecture that compactifications of M/string theory on various anti-de Sitterspacetimes is dual to various conformal field theories.This leads to a new proposal for a definition ofM-theory which could be extended to include fivenoncompact dimensions.

14,530 citations

Journal ArticleDOI
Abstract: CHARMM (Chemistry at HARvard Macromolecular Mechanics) is a highly flexible computer program which uses empirical energy functions to model macromolecular systems. The program can read or model build structures, energy minimize them by first- or second-derivative techniques, perform a normal mode or molecular dynamics simulation, and analyze the structural, equilibrium, and dynamic properties determined in these calculations. The operations that CHARMM can perform are described, and some implementation details are given. A set of parameters for the empirical energy function and a sample run are included.

14,277 citations


Showing all 208150 results

Walter C. Willett3342399413322
Eric S. Lander301826525976
Robert Langer2812324326306
Meir J. Stampfer2771414283776
Ronald C. Kessler2741332328983
JoAnn E. Manson2701819258509
Albert Hofman2672530321405
Graham A. Colditz2611542256034
Frank B. Hu2501675253464
Bert Vogelstein247757332094
George M. Whitesides2401739269833
Paul M. Ridker2331242245097
Richard A. Flavell2311328205119
Eugene Braunwald2301711264576
Ralph B. D'Agostino2261287229636
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