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Institution

Harvard University

EducationCambridge, Massachusetts, United States
About: Harvard University is a education organization based out in Cambridge, Massachusetts, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 208150 authors who have published 530388 publications receiving 38152182 citations. The organization is also known as: Harvard & University of Harvard.
Topics: Population, Cancer, Health care, Galaxy, Medicine


Papers
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Journal ArticleDOI
28 Aug 2015-Science
TL;DR: A large-scale assessment suggests that experimental reproducibility in psychology leaves a lot to be desired, and correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.
Abstract: Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.

5,532 citations

Journal ArticleDOI
TL;DR: In this article, the authors introduce and study the most basic properties of three new variational problems which are suggested by applications to computer vision, and study their application in computer vision.
Abstract: : This reprint will introduce and study the most basic properties of three new variational problems which are suggested by applications to computer vision. In computer vision, a fundamental problem is to appropriately decompose the domain R of a function g (x,y) of two variables. This problem starts by describing the physical situation which produces images: assume that a three-dimensional world is observed by an eye or camera from some point P and that g1(rho) represents the intensity of the light in this world approaching the point sub 1 from a direction rho. If one has a lens at P focusing this light on a retina or a film-in both cases a plane domain R in which we may introduce coordinates x, y then let g(x,y) be the strength of the light signal striking R at a point with coordinates (x,y); g(x,y) is essentially the same as sub 1 (rho) -possibly after a simple transformation given by the geometry of the imaging syste. The function g(x,y) defined on the plane domain R will be called an image. What sort of function is g? The light reflected off the surfaces Si of various solid objects O sub i visible from P will strike the domain R in various open subsets R sub i. When one object O1 is partially in front of another object O2 as seen from P, but some of object O2 appears as the background to the sides of O1, then the open sets R1 and R2 will have a common boundary (the 'edge' of object O1 in the image defined on R) and one usually expects the image g(x,y) to be discontinuous along this boundary. (JHD)

5,516 citations

Journal ArticleDOI
10 Mar 2008-Nature
TL;DR: In this article, the authors study the trajectory of 100,000 anonymized mobile phone users whose position is tracked for a six-month period and find that the individual travel patterns collapse into a single spatial probability distribution, indicating that humans follow simple reproducible patterns.
Abstract: The mapping of large-scale human movements is important for urban planning, traffic forecasting and epidemic prevention. Work in animals had suggested that their foraging might be explained in terms of a random walk, a mathematical rendition of a series of random steps, or a Levy flight, a random walk punctuated by occasional larger steps. The role of Levy statistics in animal behaviour is much debated — as explained in an accompanying News Feature — but the idea of extending it to human behaviour was boosted by a report in 2006 of Levy flight-like patterns in human movement tracked via dollar bills. A new human study, based on tracking the trajectory of 100,000 cell-phone users for six months, reveals behaviour close to a Levy pattern, but deviating from it as individual trajectories show a high degree of temporal and spatial regularity: work and other commitments mean we are not as free to roam as a foraging animal. But by correcting the data to accommodate individual variation, simple and predictable patterns in human travel begin to emerge. The cover photo (by Cesar Hidalgo) captures human mobility in New York's Grand Central Station. This study used a sample of 100,000 mobile phone users whose trajectory was tracked for six months to study human mobility patterns. Displacements across all users suggest behaviour close to the Levy-flight-like pattern observed previously based on the motion of marked dollar bills, but with a cutoff in the distribution. The origin of the Levy patterns observed in the aggregate data appears to be population heterogeneity and not Levy patterns at the level of the individual. Despite their importance for urban planning1, traffic forecasting2 and the spread of biological3,4,5 and mobile viruses6, our understanding of the basic laws governing human motion remains limited owing to the lack of tools to monitor the time-resolved location of individuals. Here we study the trajectory of 100,000 anonymized mobile phone users whose position is tracked for a six-month period. We find that, in contrast with the random trajectories predicted by the prevailing Levy flight and random walk models7, human trajectories show a high degree of temporal and spatial regularity, each individual being characterized by a time-independent characteristic travel distance and a significant probability to return to a few highly frequented locations. After correcting for differences in travel distances and the inherent anisotropy of each trajectory, the individual travel patterns collapse into a single spatial probability distribution, indicating that, despite the diversity of their travel history, humans follow simple reproducible patterns. This inherent similarity in travel patterns could impact all phenomena driven by human mobility, from epidemic prevention to emergency response, urban planning and agent-based modelling.

5,514 citations

Journal ArticleDOI
21 May 2015-Cell
TL;DR: Drop-seq will accelerate biological discovery by enabling routine transcriptional profiling at single-cell resolution by separating them into nanoliter-sized aqueous droplets, associating a different barcode with each cell's RNAs, and sequencing them all together.

5,506 citations

Journal ArticleDOI
29 Jun 2007-Cell
TL;DR: Those Akt substrates that are most likely to contribute to the diverse cellular roles of Akt, which include cell survival, growth, proliferation, angiogenesis, metabolism, and migration are discussed.

5,505 citations


Authors

Showing all 209304 results

NameH-indexPapersCitations
Walter C. Willett3342399413322
Eric S. Lander301826525976
Robert Langer2812324326306
Meir J. Stampfer2771414283776
Ronald C. Kessler2741332328983
JoAnn E. Manson2701819258509
Albert Hofman2672530321405
Graham A. Colditz2611542256034
Frank B. Hu2501675253464
Bert Vogelstein247757332094
George M. Whitesides2401739269833
Paul M. Ridker2331242245097
Richard A. Flavell2311328205119
Eugene Braunwald2301711264576
Ralph B. D'Agostino2261287229636
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20241
2023358
20221,907
202130,528
202029,818
201926,011