Harvard University

About: Harvard University is a education organization based out in Cambridge, Massachusetts, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 208150 authors who have published 530388 publications receiving 38152182 citations. The organization is also known as: Harvard & University of Harvard.

Human MicroRNA Targets

Abstract: MicroRNAs (miRNAs) interact with target mRNAs at specific sites to induce cleavage of the message or inhibit translation. The specific function of most mammalian miRNAs is unknown. We have predicted target sites on the 3′ untranslated regions of human gene transcripts for all currently known 218 mammalian miRNAs to facilitate focused experiments. We report about 2,000 human genes with miRNA target sites conserved in mammals and about 250 human genes conserved as targets between mammals and fish. The prediction algorithm optimizes sequence complementarity using position-specific rules and relies on strict requirements of interspecies conservation. Experimental support for the validity of the method comes from known targets and from strong enrichment of predicted targets in mRNAs associated with the fragile X mental retardation protein in mammals. This is consistent with the hypothesis that miRNAs act as sequence-specific adaptors in the interaction of ribonuclear particles with translationally regulated messages. Overrepresented groups of targets include mRNAs coding for transcription factors, components of the miRNA machinery, and other proteins involved in translational regulation, as well as components of the ubiquitin machinery, representing novel feedback loops in gene regulation. Detailed information about target genes, target processes, and open-source software for target prediction (miRanda) is available at http://www.microrna.org. Our analysis suggests that miRNA genes, which are about 1% of all human genes, regulate protein production for 10% or more of all human genes.

Multiple Intelligences: The Theory in Practice

Abstract: The Theory Of Multiple Intelligences In a Nutshell A Rounded Version (with Joseph Walters) Questions and Answers About Multiple Intelligences Theory (with Joseph Walters) The Relation of Intelligence to Other Valued Human Capacities Educating The Intelligences A School of the Future (with Tina Blythe) Interlude: The Two Rhetorics of School Reform: Complex Theories versus the Quick Fix The Emergence and Nurturance of Multiple Intelligences in Early Childhood: The Project Spectrum Approach (with Mara Krechevsky) The Elementary Years: The Project Approach in the Key School Setting Approaching School Intelligently: Practical Intelligence at the Middle School Level (with Mara Krechevsky) Disciplined Inquiry in the High School: An Introduction to Arts PROPEL Interlude: On Implementing Educational Programs: Obstacles and Opportunities Assessment And Beyond: The Components Of An MI Education Assessment in Context: The Alternative to Standardized Testing Interlude: A Portfolio Approach to College Admissions Beyond Assessment: The Aims and Means of Education The Future of Work on Multiple Intelligences Intelligences in Seven Phases Engaging Intelligence (with Mindy Kornhaber and Mara Krechevsky) Epilogue: Multiple Intelligences Theory in 2013.

Chemokines — Chemotactic Cytokines That Mediate Inflammation

Abstract: The attraction of leukocytes to tissues is essential for inflammation and the host response to infection. The process is controlled by chemokines, which are chemotactic cytokines. This review introduces the burgeoning family of cytokines, with special emphasis on their role in the pathophysiology of disease and their potential as targets for therapy. Structure and Function of Chemokines Over 40 chemokines have been identified to date, most of them in the past few years. The relations among chemokines were not initially appreciated, which led to an idiosyncratic nomenclature consisting of many acronyms. When initially identified, these proteins had no known biologic . . .

Reframing Organizations: Artistry, Choice, and Leadership

Abstract: MAKING SENSE OF ORGANIZATIONS. Introduction: The Power of Reframing. Simple Ideas, Complex Organizations. THE STRUCTURAL FRAME. Getting Organized. Structuring and Restructuring. Organizing Groups and Teams. THE HUMAN RESOURCE FRAME. People and Organizations. Human Resource Frame in Action. Groups and Interpersonal. THE POLITICAL FRAME. Power, Conflict, and Coalitions. The Manager as Politician. Organizations as Political Arenas and Political Agents. THE SYMBOLIC FRAME. Organizational Culture and Symbols. The Organization as Theater. Organizational Culture in Action. IMPROVING LEADERSHIP PRACTICE. Integrating Frames for Effective Practice. Reframing in Action: The Power of Scenarios. Choosing a Frame. Reframing Change: Training and Alignment. Reframing Leadership. Leaders as Architects and Catalysts. Leaders as Advocates and Prophets. Epilogue: Artistry, Choice, and Leadership.