scispace - formally typeset
Search or ask a question
Institution

Heidelberg University

EducationHeidelberg, Germany
About: Heidelberg University is a education organization based out in Heidelberg, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 62066 authors who have published 119109 publications receiving 4678423 citations. The organization is also known as: Ruprecht-Karls-Universität Heidelberg & University of Heidelberg.
Topics: Population, Transplantation, Galaxy, Cancer, Stars


Papers
More filters
Journal ArticleDOI
TL;DR: The Gini importance of the random forest provided superior means for measuring feature relevance on spectral data, but – on an optimal subset of features – the regularized classifiers might be preferable over the random Forest classifier, in spite of their limitation to model linear dependencies only.
Abstract: Regularized regression methods such as principal component or partial least squares regression perform well in learning tasks on high dimensional spectral data, but cannot explicitly eliminate irrelevant features. The random forest classifier with its associated Gini feature importance, on the other hand, allows for an explicit feature elimination, but may not be optimally adapted to spectral data due to the topology of its constituent classification trees which are based on orthogonal splits in feature space. We propose to combine the best of both approaches, and evaluated the joint use of a feature selection based on a recursive feature elimination using the Gini importance of random forests' together with regularized classification methods on spectral data sets from medical diagnostics, chemotaxonomy, biomedical analytics, food science, and synthetically modified spectral data. Here, a feature selection using the Gini feature importance with a regularized classification by discriminant partial least squares regression performed as well as or better than a filtering according to different univariate statistical tests, or using regression coefficients in a backward feature elimination. It outperformed the direct application of the random forest classifier, or the direct application of the regularized classifiers on the full set of features. The Gini importance of the random forest provided superior means for measuring feature relevance on spectral data, but – on an optimal subset of features – the regularized classifiers might be preferable over the random forest classifier, in spite of their limitation to model linear dependencies only. A feature selection based on Gini importance, however, may precede a regularized linear classification to identify this optimal subset of features, and to earn a double benefit of both dimensionality reduction and the elimination of noise from the classification task.

726 citations

Journal ArticleDOI
TL;DR: X‐ray crystal structures of two zinc endopeptidases, astacin from crayfish and adamalysin II from snake venom, reveal a strong overall topological equivalence and virtually identical extended HEXXHXXGXXH zinc‐binding segments, but in addition a methionine‐containing turn of similar conformation (the ‘Met‐turn’), which forms a hydrophobic basis for the zinc ion and the three liganding histidine residues.

725 citations

Journal ArticleDOI
TL;DR: In this paper, an integrated interferometer based on a simple coherent matter-wave beam splitter constructed on an atom chip is presented, where the authors demonstrate the splitting of Bose-Einstein condensates into two clouds separated by distances ranging from 3 to 80μm.
Abstract: Matter-wave interference experiments enable us to study matter at its most basic, quantum level and form the basis of high-precision sensors for applications such as inertial and gravitational field sensing. Success in both of these pursuits requires the development of atom-optical elements that can manipulate matter waves at the same time as preserving their coherence and phase. Here, we present an integrated interferometer based on a simple, coherent matter-wave beam splitter constructed on an atom chip. Through the use of radio-frequency-induced adiabatic double-well potentials, we demonstrate the splitting of Bose–Einstein condensates into two clouds separated by distances ranging from 3 to 80 μm, enabling access to both tunnelling and isolated regimes. Moreover, by analysing the interference patterns formed by combining two clouds of ultracold atoms originating from a single condensate, we measure the deterministic phase evolution throughout the splitting process. We show that we can control the relative phase between the two fully separated samples and that our beam splitter is phase-preserving.

724 citations

Journal ArticleDOI
Peter A. R. Ade1, Nabila Aghanim2, Yashar Akrami3, Yashar Akrami4  +310 moreInstitutions (70)
TL;DR: In this article, the statistical isotropy and Gaussianity of the cosmic microwave background (CMB) anisotropies using observations made by the Planck satellite were investigated.
Abstract: We test the statistical isotropy and Gaussianity of the cosmic microwave background (CMB) anisotropies using observations made by the Planck satellite. Our results are based mainly on the full Planck mission for temperature, but also include some polarization measurements. In particular, we consider the CMB anisotropy maps derived from the multi-frequency Planck data by several component-separation methods. For the temperature anisotropies, we find excellent agreement between results based on these sky maps over both a very large fraction of the sky and a broad range of angular scales, establishing that potential foreground residuals do not affect our studies. Tests of skewness, kurtosis, multi-normality, N-point functions, and Minkowski functionals indicate consistency with Gaussianity, while a power deficit at large angular scales is manifested in several ways, for example low map variance. The results of a peak statistics analysis are consistent with the expectations of a Gaussian random field. The “Cold Spot” is detected with several methods, including map kurtosis, peak statistics, and mean temperature profile. We thoroughly probe the large-scale dipolar power asymmetry, detecting it with several independent tests, and address the subject of a posteriori correction. Tests of directionality suggest the presence of angular clustering from large to small scales, but at a significance that is dependent on the details of the approach. We perform the first examination of polarization data, finding the morphology of stacked peaks to be consistent with the expectations of statistically isotropic simulations. Where they overlap, these results are consistent with the Planck 2013 analysis based on the nominal mission data and provide our most thorough view of the statistics of the CMB fluctuations to date.

724 citations

Journal ArticleDOI
TL;DR: Doppler ultrasound measurement for ABI determinations is a non-invasive, inexpensive, reliable tool in primary care and enables GPs to identify patients at risk of PAD, particularly with regard to other manifestations of atherothrombosis.

724 citations


Authors

Showing all 62427 results

NameH-indexPapersCitations
Nicholas G. Martin1921770161952
Jing Wang1844046202769
Chris Sander178713233287
Kenneth C. Anderson1781138126072
Zena Werb168473122629
Marc Weber1672716153502
Volker Springel165746123399
Ira Pastan1601286110069
Wolfgang Wagner1562342123391
Jovan Milosevic1521433106802
Hermann Brenner1511765145655
Robert J. Sternberg149106689193
Margaret A. Pericak-Vance149826118672
Andreas Pfeiffer1491756131080
Rajesh Kumar1494439140830
Network Information
Related Institutions (5)
Ludwig Maximilian University of Munich
161.5K papers, 5.7M citations

98% related

University of Zurich
124K papers, 5.3M citations

95% related

University of Amsterdam
140.8K papers, 5.9M citations

94% related

Harvard University
530.3K papers, 38.1M citations

93% related

University of Helsinki
113.1K papers, 4.6M citations

93% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023191
2022729
20216,243
20206,124
20195,659
20185,388