Heidelberg University

About: Heidelberg University is a education organization based out in Heidelberg, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 62066 authors who have published 119109 publications receiving 4678423 citations. The organization is also known as: Ruprecht-Karls-Universität Heidelberg & University of Heidelberg.

Differentiation of mouse embryonic stem cells into a defined neuronal lineage

Abstract: Although it has long been known that cultured embryonic stem cells can generate neurons, the lineage relationships with their immediate precursors remain unclear. We report here that selection of highly proliferative stem cells followed by treatment with retinoic acid generated essentially pure precursors that markers identified as Pax-6-positive radial glial cells. As they do in vivo, these cells went on to generate neurons with remarkably uniform biochemical and electrophysiological characteristics.

Searches for Lepton Flavor Violation in the Decays tau(+/-) -> e(+/-)gamma and tau(+/-) -> mu(+/-)gamma

Abstract: Searches for lepton-flavor-violating decays of a tau lepton to a lighter mass lepton and a photon have been performed with the entire data set of (963 +/- 7) x 10(6) tau decays collected by the BABAR detector near the Y(4S), Y(3S) and Y(2S) resonances. The searches yield no evidence of signals and we set upper limits on the branching fractions of B(tau(+/-) -> e(+/-)gamma) mu(+/-)gamma) < 4.4 X 10(-8) at 90% confidence level.

Proposal for a unified norovirus nomenclature and genotyping.

Abstract: Noroviruses belong to a genus of genetically diverse viruses within the family Caliciviridae and cause acute gastroenteritis in humans and animals. They are subdivided into genogroups, each of which further segregates into genotypes. Until recently, a new genotype was based on a defined pairwise distance cutoff of complete VP1 sequences, but with the increasing number of available norovirus sequences, this cutoff is no longer accurate, and sequences in the public database have been misclassified. In this paper, we demonstrate that the pairwise distance cutoff method can no longer be used and outline a phylogenetic approach to classify noroviruses. Furthermore, we propose a dual nomenclature using both ORF1 and VP1 sequences, as recombination is common and recognizing recombinant viruses may be relevant. With the continuing emergence of new norovirus lineages, we propose to coordinate nomenclature of new norovirus genotypes through an international norovirus working group.

The Aquila comparison project: the effects of feedback and numerical methods on simulations of galaxy formation

Abstract: We compare the results of various cosmological gas-dynamical codes used to simulate the formation of a galaxy in the Λ cold dark matter structure formation paradigm. The various runs (13 in total) differ in their numerical hydrodynamical treatment [smoothed particle hydrodynamics (SPH), moving mesh and adaptive mesh refinement] but share the same initial conditions and adopt in each case their latest published model of gas cooling, star formation and feedback. Despite the common halo assembly history, we find large code-to-code variations in the stellar mass, size, morphology and gas content of the galaxy at z= 0, due mainly to the different implementations of star formation and feedback. Compared with observation, most codes tend to produce an overly massive galaxy, smaller and less gas rich than typical spirals, with a massive bulge and a declining rotation curve. A stellar disc is discernible in most simulations, although its prominence varies widely from code to code. There is a well-defined trend between the effects of feedback and the severity of the disagreement with observed spirals. In general, models that are more effective at limiting the baryonic mass of the galaxy come closer to matching observed galaxy scaling laws, but often to the detriment of the disc component. Although numerical convergence is not particularly good for any of the codes, our conclusions hold at two different numerical resolutions. Some differences can also be traced to the different numerical techniques; for example, more gas seems able to cool and become available for star formation in grid-based codes than in SPH. However, this effect is small compared to the variations induced by different feedback prescriptions. We conclude that state-of-the-art simulations cannot yet uniquely predict the properties of the baryonic component of a galaxy, even when the assembly history of its host halo is fully specified. Developing feedback algorithms that can effectively regulate the mass of a galaxy without hindering the formation of high angular momentum stellar discs remains a challenge.