Institution
Israel Ministry of Health
Government•Jerusalem, Israel•
About: Israel Ministry of Health is a government organization based out in Jerusalem, Israel. It is known for research contribution in the topics: Population & Public health. The organization has 1633 authors who have published 2108 publications receiving 65387 citations.
Topics: Population, Public health, Health care, Vaccination, Pregnancy
Papers published on a yearly basis
Papers
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TL;DR: In this article, the safety and immunogenicity of a third, booster, dose of the Pfizer BNT162b2 vaccine in heart transplant (HT) patients were investigated, and the third dose was associated with a low rate of adverse events, mostly mild pain at the injection site.
Abstract: BACKGROUND The repeated waves of the COVID-19 pandemic have highlighted the necessity to optimize vaccine responses in immunocompromised populations. We investigated the safety and immunogenicity of a third, booster, dose of the Pfizer BNT162b2 vaccine in heart transplant (HT) patients. METHODS The cohort comprised 96 adult HT patients who received a third homologous dose of the BNT162b2 vaccine 168 days after the second dose. The vaccine-induced antibody responses of both receptor-binding domain (RBD) IgG and neutralizing antibodies were assessed in all patients, with a positive antibody response being defined as the presence of either IgG anti-RBD or neutralizing antibodies. For a subset of patients, T cell response was also studied. RESULTS The third dose was associated with a low rate of adverse events, mostly mild pain at the injection site. No serious adverse events were recorded, and there were no episodes of rejection. At 18 days following the third dose of the vaccine, the positive antibody response increased from 23% to 67%, with a corresponding increase in neutralizing capacity. The third dose elicited SARS-CoV-2 neutralization titers >9-fold and IgG anti-RBD antibodies >3-fold of the range achieved after the two primary doses. Mycophenolate use, lower eGFR and higher C-reactive protein were independently associated with a reduced likelihood of generating an immune response. Importantly, a specific T-cell response following the third dose was evident in the majority of transplant recipients. CONCLUSIONS An homologous third booster dose of the BNT162b2 vaccine gave overall consistent tolerability and a good safety profile, while eliciting humoral and cellular immune responses.
73 citations
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TL;DR: This study demonstrates that the ribotype 027 strain has disseminated across Israel and is now the most common strain.
73 citations
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TL;DR: In this paper, the authors assessed the clinical features, radiologic findings, and drug sensitivity associated with M kansasii infection in Israel and found that patients with this infection have no association with HIV, more systemic comorbid diseases and associated lung disease and fewer cavitations.
73 citations
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TL;DR: Assessment of the levels of the various variables describing individual social capital in Jews and Arab residing in Israel revealed that Jews reported higher levels of social trust, perceived helpfulness, trust in authorities, and social support compared to Arabs, after adjusting for demographic and socioeconomic variables.
72 citations
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TL;DR: A patient with lymphosarcoma treated with weekly injections of vincristine developed an acute myocardial infarction immediately after the second injection of vINCristine, and the treatment was continued and he developed an additionalMyocardial Infarction.
Abstract: A patient with lymphosarcoma treated with weekly injections of vincristine developed an acute myocardial infarction immediately after the second injection of vincristine. After he recovered from the infarction, the treatment was continued and he developed an additional myocardial infarction. In vivo and in vitro studies have not revealed any effect of vincristine on the clotting mechanism. The possible causes for the association of vincristine-treated lymphoma and myocardial infarction are discussed.
72 citations
Authors
Showing all 1636 results
Name | H-index | Papers | Citations |
---|---|---|---|
Gideon Koren | 129 | 1994 | 81718 |
Yuman Fong | 125 | 865 | 63931 |
Jeffrey M. Hausdorff | 106 | 401 | 52287 |
Yehuda Carmeli | 88 | 351 | 37154 |
Aaron Cohen | 78 | 412 | 66543 |
Igor M. Sokolov | 69 | 673 | 20256 |
Asher Ornoy | 67 | 367 | 13274 |
Robert H. Belmaker | 65 | 436 | 19583 |
Adam P. Dicker | 65 | 502 | 16964 |
Hagit Cohen | 64 | 219 | 13079 |
Jose Bras | 60 | 187 | 20081 |
Moshe Kotler | 59 | 257 | 11376 |
Baruch Modan | 59 | 202 | 18447 |
Zvi Laron | 58 | 511 | 14532 |
Roz Shafran | 57 | 240 | 20092 |