Jimei University

About: Jimei University is a education organization based out in Amoy, China. It is known for research contribution in the topics: Computer science & Population. The organization has 4645 authors who have published 4293 publications receiving 42239 citations. The organization is also known as: Jíměi Dàxué.

Numerical Analysis of Cold Spray Particles Impacting Behavior by the Eulerian Method: A Review

Abstract: Numerical simulations have been widely used to study particles impacting behavior in cold spraying. Among the used simulation methods, the Eulerian frame becomes increasingly attractive for its absence of mesh distortion which happens in the Lagrangian frame. It has been proved that particle deformation behaviors upon impacting calculated by the Eulerian method are well comparable to the experimental observations. In this review article, the literature on modeling particle impacting by the Eulerian method was summarized. In the second part, the Eulerian method was detailedly introduced. In the third part, the particle/substrate impacting behavior, and its influencing factors, i.e., mesh resolution, particle impacting velocity, preheating (particle or/and substrate) and oxide film, were summarized. Additionally, the prediction of critical velocity and residual stresses by using the Eulerian method was also discussed in detail. Finally, the current issues, problems and prospects existing in the Eulerian simulations of particle impacting were explored.

Docosahexaenoic acid aggravates photooxidative damage in retinal pigment epithelial cells via lipid peroxidation.

Abstract: Docosahexaenoic acid (DHA, 22:6n-3), a long-chain polyunsaturated fatty acid (PUFA) with important functions in normal human retinal activity and vision development, is recommended to promote brain and eye development. However, recent research has revealed that increased DHA level in the retina due to linoleic acid-rich diet heightens the vulnerability of the retina to photooxidative stress. Thus, many scholars have analyzed the potential risks of DHA intake on retinal damage. This study evaluated the potential adverse effects of DHA intake on individuals usually exposed to high-light intensity conditions using a visible light-induced retinal pigment epithelium (RPE) cell damage model in vitro. Results showed that DHA promoted the proliferation of RPE cells without any cytotoxicity under dark conditions. However, DHA supplement elicited deleterious effects on RPE cells under high-intensity light conditions. That is, DHA supplement inhibited cellular proliferation, destroyed cell membrane integrity, enhanced cellular senescence, increased vascular endothelial growth factor (VEGF) release, and decreased phagocytic function. Moreover, DHA supplement increased the intracellular and extracellular levels of reactive oxygen species and the extracellular level of lipid peroxidation products under high-intensity light conditions. These results demonstrate that DHA increases the vulnerability of the retina to light damage through lipid peroxidation.

Visible Light-Induced Lipid Peroxidation of Unsaturated Fatty Acids in the Retina and the Inhibitory Effects of Blueberry Polyphenols.

Abstract: The lipid peroxidation of unsaturated fatty acids (UFAs) in the retina not only threatens visual cells but also affects the physiological health of the retina. In this work, the potential damages caused by daily visible light exposure on retinal UFAs were evaluated via a simulated in vitro model. At the same time, the benefits of dietary supplementation of blueberries to the eyes were also assessed. After prolonged light exposure, lipid peroxidation occurred for both docosahexaenoic and arachidonic acids (DHA and AA, respectively). The oxidized UFAs presented obvious cytotoxicity and significantly inhibited cell growth in retinal pigment epithelium cells. Among the different blueberry polyphenol fractions, the flavonoid-rich fraction, in which quercetin was discovered as the main component, was considerably better in preventing visible light-induced DHA lipid peroxidation than the anthocyanin- and phenolic acid-rich fractions. Then the retinal protective activity of blueberry polyphenols against light-induced retinal injury was confirmed in vivo. On the basis of the above results, inhibiting lipid peroxidation of UFAs in the retina is proposed to be another important function mechanism for antioxidants to nourish eyes.