Jimei University

About: Jimei University is a education organization based out in Amoy, China. It is known for research contribution in the topics: Computer science & Population. The organization has 4645 authors who have published 4293 publications receiving 42239 citations. The organization is also known as: Jíměi Dàxué.

clpV is a key virulence gene during in vivo Pseudomonas plecoglossicida infection.

Abstract: Interaction between bacterial pathogen and aquatic animal host is exceedingly complex, which involves large dynamic changes in gene expression during different stages of the disease. However, research on identifying key virulence genes based on the dynamics of gene expression changes of a one-sided bacterial pathogen in tissue has not been reported so far across different stages of infectious disease. The clpV for the T6SS of Pseudomonas plecoglossicida was identified for a candidate for key virulence gene based on dynamic changes of gene expression. For the Epinephelus coioides infected using clpV-RNAi strain, no deaths were observed up to 20 dpi. The spleens, kidneys and livers of all the E. coioides that received clpV-RNAi strain failed to develop visible nodules at 5-8 dpi, with the swelling gradually disappearing. The burdens of clpV-RNAi strain in the spleen and blood were greatly reduced at most of the time points after injection, and the burdens of clpV-RNAi strain in the head kidneys and trunk kidneys also had a sharp reduction from 72 to 120 hpi. This paper provides a new insight into the discovery of key virulence genes of pathogens in infected tissue systems.

Singularities and the Finale of Black Hole Evaporation

Abstract: In this paper, we argue that once quantum gravitational effects change the classical geometry of a black hole and remove the curvature singularity, the black hole would not evaporate entirely but approach a remnant. In a modified Schwarzschild spacetime characterized by a finite Kretschmann scalar, a minimal mass of the black hole is naturally bounded by the existence of the horizon rather than introduced by hand. A thermodynamical analysis discloses that the temperature, heat capacity and the luminosity vanish naturally when the black hole mass approaches the minimal value. This phenomenon may be attributed to the existence of the minimal length in quantum gravity. It can also be understood heuristically by connecting the generalized uncertainty principle with the running of Newton's gravitational constant.