Mepco Schlenk Engineering College

About: Mepco Schlenk Engineering College is a based out in . It is known for research contribution in the topics: Wavelet & Wavelet transform. The organization has 1307 authors who have published 1665 publications receiving 18690 citations.

Surface receptor-mediated targeted drug delivery systems for enhanced cancer treatment: A state-of-the-art review.

Abstract: Enhanced cancer treatment remains as one of the focused areas for researchers around the world. Hence, the progress in this direction will be a challenge and an opportunity in, inter-disciplinary field to mitigate the suffering of millions in the upcoming decades. As we see, cancer death rate has also progressively increased despite the current impressive treatment regimens but also due to the non-availability of vaccines and the re-occurring of cancer in substantially recovered patients. Currently, numerous treatment strategies like surgical removal of solid tumors followed by radiation with a combination of immunotherapy/chemotherapy by the researchers and clinicians are routinely being followed. However, recurrence and distant metastasis often occur following radiation therapy, commonly due to the generation of radio-resistance through deregulation of the cell cycle, cell death, and inhibition of DNA damage repair mechanisms. Thus, chemotherapeutic/immunotherapeutic treatment systems have progressed remarkably in the latest years owing to destroying tumors, noninvasive, and affordable charge of therapy. But, traditional chemotherapeutic approaches target the DNA of mutated and normal healthy cells, resulting in a significantly increased risk of toxicity and drug resistance. Thus, many receptors targeted therapies are in the developmental phase of discovery. Cancer cells have a specialized set of surface receptors that provide potential targets for cancer therapeutics. Cell surface receptor-dependent endocytosis is well a known major mechanism for the internalization of macromolecular drugs. This review emphasizes the recent development of several surface receptors mediated cancer-targeting approaches for the effective delivery of various therapeutic formulations.

Metal based pharmacologically active complexes of Cu(II), Ni(II) and Zn(II): synthesis, spectral, XRD, antimicrobial screening, DNA interaction and cleavage investigation.

Abstract: The present contribution reports a thorough characterization of newly obtained metallointercalators incorporating Schiff bases, formed by the condensation of N-acetoacetyl-o-toluidine with 1-amino-4-nitrobenzene (L(1))/1-amino-4-chlorobenzene (L(2)) as main ligand and 1,10-phenanthroline as co-ligand respectively. The characterization of newly formed metallointercalators has been done by (1)H NMR, UV-Vis, IR, EPR spectroscopy and molar conductivity studies. X-ray powder diffraction illustrates that they are crystalline nature. Binding interaction of these complexes with calf thymus (CT-DNA) has been investigated by emission, absorption, viscosity, cyclic voltammetry and differential pulse voltammetry. DNA binding experiments results reveal that the synthesized complexes interact with DNA through intercalative mode. The in vitro antibacterial and antifungal assay indicate that these complexes are good antimicrobial agents against various pathogens. The DNA cleavage exhibits that they act as efficient cleaving agents.

Rice husk as nanoadditive in diesel–biodiesel fuel blends used in diesel engine

Abstract: The fossil fuels are gradually reducing due to the increase in energy users and prices. In India the biodiesel is one of the best available renewable energy sources to satisfy the energy demand and environmentally friendly nature. In the present work, non-edible feedstock of pongamia pinnata seed oil is used for biodiesel production. The biodiesel was prepared by transesterification method with methanol in the existence of KOH as catalyst, and in addition of rice husk (RH) nano-organic additive is used in biodiesel production. The RH nanoparticles are characterized by using scanning electron microscopy, transmission electron microscopy (TEM), X-ray diffraction and the CHNS elemental analysis. TEM results confirm that the RH nanoparticle has size of around 20 nm. The pure diesel, 20% biodiesel 80% diesel and 20% biodiesel 80% diesel with 0.1% RH nanoparticles are used as fuels in the diesel engine. The performance and emission characteristics of the IC engine are studied. The results showed that the RH nanoparticles added with pongamia seed oil methyl ester improve the brake thermal efficiency, reduced CO, HC emissions and lowered the NOx emissions.