Institution
Queen's University
Education•Kingston, Ontario, Canada•
About: Queen's University is a education organization based out in Kingston, Ontario, Canada. It is known for research contribution in the topics: Population & Poison control. The organization has 41065 authors who have published 78811 publications receiving 2864794 citations. The organization is also known as: Queen's College at Kingston.
Papers published on a yearly basis
Papers
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TL;DR: As de facto determinants of antimicrobial, even multidrug, resistance, stress responses may be worthy of consideration as therapeutic targets.
Abstract: Bacteria encounter a myriad of stresses in their natural environments, including, for pathogens, their hosts. These stresses elicit a variety of specific and highly regulated adaptive responses that not only protect bacteria from the offending stress, but also manifest changes in the cell that impact innate antimicrobial susceptibility. Thus exposure to nutrient starvation/limitation (nutrient stress), reactive oxygen and nitrogen species (oxidative/nitrosative stress), membrane damage (envelope stress), elevated temperature (heat stress) and ribosome disruption (ribosomal stress) all impact bacterial susceptibility to a variety of antimicrobials through their initiation of stress responses that positively impact recruitment of resistance determinants or promote physiological changes that compromise antimicrobial activity. As de facto determinants of antimicrobial, even multidrug, resistance, stress responses may be worthy of consideration as therapeutic targets.
437 citations
TL;DR: In a subgroup analysis from PROactive, pioglitazone reduced the risk of recurrent stroke significantly in high-risk patients with type 2 diabetes.
Abstract: Background and Purpose— Diabetes is an important risk factor for stroke. We conducted analyses in patients who had entered the PROspective pioglitAzone Clinical Trial In macroVascular Events (PROactive) with a history of stroke or without stroke. Methods— The prospective, double-blind PROactive (mean duration, 34.5 months) randomized 5238 patients with type 2 diabetes and a history of macrovascular disease to pioglitazone (titrated to 45 mg) or placebo, in addition to current diabetes and cardiovascular medications. Cardiovascular end-point events were independently adjudicated. This analysis evaluated the risk of stroke and other cardiovascular outcomes in patients with (n=984) and without (n=4254) prior stroke. Results— In patients with previous stroke (n=486 in the pioglitazone group and n=498 in the placebo group), there was a trend of benefit with pioglitazone for the primary end point of all-cause death, nonfatal myocardial infarction, acute coronary syndrome, and cardiac intervention (including cor...
436 citations
TL;DR: The wild bootstrap was originally developed for regression models with heteroskedasticity of unknown form and has been extended to models estimated by instrumental variables over the past 30 years as discussed by the authors.
Abstract: The wild bootstrap was originally developed for regression models with heteroskedasticity of unknown form. Over the past 30 years, it has been extended to models estimated by instrumental variables...
436 citations
University of Florida1, Fermilab2, Texas A&M University3, University of Minnesota4, University of Illinois at Urbana–Champaign5, Massachusetts Institute of Technology6, Syracuse University7, South Dakota School of Mines and Technology8, Stanford University9, University of California, Berkeley10, Southern Methodist University11, Durham University12, California Institute of Technology13, Queen's University14, Autonomous University of Madrid15, Northwestern University16, Pacific Northwest National Laboratory17, University of Colorado Denver18, University of British Columbia19, University of Evansville20, University of South Dakota21, Santa Clara University22
TL;DR: The CDMS low ionization threshold experiment (CDMSlite) uses cryogenic germanium detectors operated at a relatively high bias voltage to amplify the phonon signal in the search for weakly interacting massive particles (WIMPs).
Abstract: The CDMS low ionization threshold experiment (CDMSlite) uses cryogenic germanium detectors operated at a relatively high bias voltage to amplify the phonon signal in the search for weakly interacting massive particles (WIMPs). Results are presented from the second CDMSlite run with an exposure of 70 kg day, which reached an energy threshold for electron recoils as low as 56 eV. A fiducialization cut reduces backgrounds below those previously reported by CDMSlite. New parameter space for the WIMP-nucleon spin-independent cross section is excluded for WIMP masses between 1.6 and 5.5 GeV/c^{2}.
436 citations
TL;DR: It is demonstrated that inhibition of leukotriene synthesis results in a marked acceleration of the healing of Colonic ulcers and resolution of colonic inflammation in this animal model of chronic colitis, consistent with the hypothesis thatLeukotrienes play an important role in the pathogenesis of intestinal inflammation.
435 citations
Authors
Showing all 41312 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Karl J. Friston | 217 | 1267 | 217169 |
| David Miller | 203 | 2573 | 204840 |
| Raymond J. Dolan | 196 | 919 | 138540 |
| Matthew Meyerson | 194 | 553 | 243726 |
| Stephen V. Faraone | 188 | 1427 | 140298 |
| Deborah J. Cook | 173 | 907 | 148928 |
| Feng Zhang | 172 | 1278 | 181865 |
| David Cameron | 154 | 1586 | 126067 |
| David J. Brooks | 152 | 1056 | 94335 |
| Rajesh Kumar | 149 | 4439 | 140830 |
| J. Fraser Stoddart | 147 | 1239 | 96083 |
| Richard S. J. Frackowiak | 142 | 309 | 100726 |
| Hal Evans | 141 | 1445 | 107406 |
| Andrew J. Lees | 140 | 877 | 91605 |
| Janet Rossant | 138 | 416 | 71913 |