SRI International

About: SRI International is a nonprofit organization based out in Menlo Park, California, United States. It is known for research contribution in the topics: Ionosphere & Laser. The organization has 7222 authors who have published 13102 publications receiving 660724 citations. The organization is also known as: Stanford Research Institute & SRI.

Erythropoietin receptor expression in adult rat cardiomyocytes is associated with an acute cardioprotective effect for recombinant erythropoietin during ischemia-reperfusion injury.

Abstract: Erythropoietin (EPO), the principal hematopoietic cytokine that regulates mammalian erythropoiesis, exhibits diverse cellular effects in non-hematopoietic tissues. The physiologic functions of EPO are mediated by its specific cell-surface receptor EPOR. In this study, we demonstrate EPOR expression in adult rat cardiac myocytes and examine the direct effects of EPO on the heart to investigate whether recombinant EPO may exert an acute cardioprotective effect during ischemia-reperfusion injury. To determine whether EPO is cardioprotective, isolated rat hearts were perfused for 10 min in the Langendorff-mode with Krebs-Henseleit buffer in the absence or presence of brief recombinant EPO treatment while left-ventricular-developed pressure (LVDP) was measured continuously to assess contractile function. The hearts were then subjected to 20 min of normothermic global ischemia followed by 25 min of reperfusion. The post-ischemic recovery of LVDP in the untreated control hearts was 26 +/- 5% of their baseline LVDP, whereas hearts pretreated with EPO exhibited significantly improved post-ischemic recovery to 57 +/- 7%. We used 31P nuclear magnetic resonance (NMR) spectroscopy to determine whether modulation of intracellular pH and/or high-energy phosphate levels during ischemia contributed to EPO-mediated cardioprotection. These experiments revealed that the rapid cardioprotective effect of EPO during ischemia-reperfusion injury was associated with preservation of ATP levels in the ischemic myocardium.

Rosemary: A Robust, Secure, and High-performance Network Operating System

Abstract: Within the hierarchy of the Software Defined Network (SDN) network stack, the control layer operates as the critical middleware facilitator of interactions between the data plane and the network applications, which govern flow routing decisions. In the OpenFlow implementation of the SDN model, the control layer, commonly referred to as a network operating system (NOS), has been realized by a range of competing implementations that offer various performance and functionality advantages: Floodlight, POX, NOX, and ONIX. In this paper we focus on the question of control layer resilience, when rapidly developed prototype network applications go awry, or third-party network applications incorporate unexpected vulnerabilities, fatal instabilities, or even malicious logic. We demonstrate how simple and common failures in a network application may lead to loss of the control layer, and in effect, loss of network control. To address these concerns we present the ROSEMARY controller, which implements a network application containment and resilience strategy based around the notion of spawning applications independently within a micro-NOS. ROSEMARY distinguishes itself by its blend of process containment, resource utilization monitoring, and an application permission structure, all designed to prevent common failures of network applications from halting operation of the SDN Stack. We present our design and implementation of ROSEMARY, along with an extensive evaluation of its performance relative to several of the mostly well-known and widely used controllers. Rather than imposing significant performance costs, we find that with the integration of two optimization features, ROSEMARY offers a competitive performance advantage over the majority of other controllers.

Comparative Analysis of Policies for ICT in Education

Abstract: National policies and programs can be an important tool for the realization of ICTs promise in education and some of their major components are the focus of this chapter. The chapter presents a framework of alternative rationales and program components that can be used by researchers and policymakers to analyze, formulate, revise, and compare national ICT efforts. The framework consists of four alternative policy rationales-or “strategic” policy positions-and five components of ICT programs, or “operational” policies. Strategic and operational policies of various countries are used to illustrate these rationales and components. The chapter concludes with recommendations that countries can use when formulating or updating their educational ICT plans.

Generic virtual personal assistant platform

Abstract: A method for assisting a user with one or more desired tasks is disclosed. For example, an executable, generic language understanding module and an executable, generic task reasoning module are provided for execution in the computer processing system. A set of run-time specifications is provided to the generic language understanding module and the generic task reasoning module, comprising one or more models specific to a domain. A language input is then received from a user, an intention of the user is determined with respect to one or more desired tasks, and the user is assisted with the one or more desired tasks, in accordance with the intention of the user.