Stanford University

About: Stanford University is a education organization based out in Stanford, California, United States. It is known for research contribution in the topics: Population & Transplantation. The organization has 125751 authors who have published 320347 publications receiving 21892059 citations. The organization is also known as: Leland Stanford Junior University & University of Stanford.

Shifts in Gamma Phase–Amplitude Coupling Frequency from Theta to Alpha Over Posterior Cortex During Visual Tasks

Abstract: The phase of ongoing theta (4-8 Hz) and alpha (8-12 Hz) electrophysiological oscillations is coupled to high gamma (80-150 Hz) amplitude, which suggests that low frequency oscillations modulate local cortical activity. While this phase-amplitude coupling (PAC) has been demonstrated in a variety of tasks and cortical regions, it has not been shown whether task demands differentially affect the regional distribution of the preferred low-frequency coupling to high gamma. To address this issue we investigated multiple-rhythm theta/alpha phase to high gamma amplitude PAC in two subjects with implanted subdural electrocorticographic grids. We show that high gamma amplitude couples to the theta and alpha troughs and demonstrate that, during visual tasks, alpha/high gamma coupling preferentially increases in visual cortical regions. These results suggest that low-frequency phase to high-frequency amplitude PAC is modulated by behavioral task and may reflect a mechanism for selection between communicating neuronal networks.

Trophic cascade facilitates coral recruitment in a marine reserve

Abstract: Reduced fishing pressure and weak predator–prey interactions within marine reserves can create trophic cascades that increase the number of grazing fishes and reduce the coverage of macroalgae on coral reefs. Here, we show that the impacts of reserves extend beyond trophic cascades and enhance the process of coral recruitment. Increased fish grazing, primarily driven by reduced fishing, was strongly negatively correlated with macroalgal cover and resulted in a 2-fold increase in the density of coral recruits within a Bahamian reef system. Our conclusions are robust because four alternative hypotheses that may generate a spurious correlation between grazing and coral recruitment were tested and rejected. Grazing appears to influence the density and community structure of coral recruits, but no detectable influence was found on the overall size-frequency distribution, community structure, or cover of corals. We interpret this absence of pattern in the adult coral community as symptomatic of the impact of a recent disturbance event that masks the recovery trajectories of individual reefs. Marine reserves are not a panacea for conservation but can facilitate the recovery of corals from disturbance and may help sustain the biodiversity of organisms that depend on a complex three-dimensional coral habitat.

No country for old members: user lifecycle and linguistic change in online communities

Abstract: Vibrant online communities are in constant flux. As members join and depart, the interactional norms evolve, stimulating further changes to the membership and its social dynamics. Linguistic change --- in the sense of innovation that becomes accepted as the norm --- is essential to this dynamic process: it both facilitates individual expression and fosters the emergence of a collective identity. We propose a framework for tracking linguistic change as it happens and for understanding how specific users react to these evolving norms. By applying this framework to two large online communities we show that users follow a determined two-stage lifecycle with respect to their susceptibility to linguistic change: a linguistically innovative learning phase in which users adopt the language of the community followed by a conservative phase in which users stop changing and the evolving community norms pass them by. Building on this observation, we show how this framework can be used to detect, early in a user's career, how long she will stay active in the community. Thus, this work has practical significance for those who design and maintain online communities. It also yields new theoretical insights into the evolution of linguistic norms and the complex interplay between community-level and individual-level linguistic change.

IRM: integrated region matching for image retrieval

Abstract: Content-based image retrieval using region segmentation has been an active research area. We present IRM (Integrated Region Matching), a novel similarity measure for region-based image similarity comparison. The targeted image retrieval systems represent an image by a set of regions, roughly corresponding to objects, which are characterized by features reflecting color, texture, shape, and location properties. The IRM measure for evaluating overall similarity between images incorporates properties of all the regions in the images by a region-matching scheme. Compared with retrieval based on individual regions, the overall similarity approach reduces the influence of inaccurate segmentation, helps to clarify the semantics of a particular region, and enables a simple querying interface for region-based image retrieval systems. The IRM has been implemented as a part of our experimental SIMPLIcity image retrieval system. The application to a database of about 200,000 general-purpose images shows exceptional robustness to image alterations such as intensity variation, sharpness variation, color distortions, shape distortions, cropping, shifting, and rotation. Compared with several existing systems, our system in general achieves more accurate retrieval at higher speed.

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor.

Abstract: BackgroundExpression of the colony-stimulating factor 1 (CSF1) gene is elevated in most tenosynovial giant-cell tumors. This observation has led to the discovery and clinical development of therapy targeting the CSF1 receptor (CSF1R). MethodsUsing x-ray co-crystallography to guide our drug-discovery research, we generated a potent, selective CSF1R inhibitor, PLX3397, that traps the kinase in the autoinhibited conformation. We then conducted a multicenter, phase 1 trial in two parts to analyze this compound. In the first part, we evaluated escalations in the dose of PLX3397 that was administered orally in patients with solid tumors (dose-escalation study). In the second part, we evaluated PLX3397 at the chosen phase 2 dose in an extension cohort of patients with tenosynovial giant-cell tumors (extension study). Pharmacokinetic and tumor responses in the enrolled patients were assessed, and CSF1 in situ hybridization was performed to confirm the mechanism of action of PLX3397 and that the pattern of CSF1 ex...