State University of Campinas

About: State University of Campinas is a education organization based out in Campinas, Brazil. It is known for research contribution in the topics: Population & Context (language use). The organization has 49454 authors who have published 104606 publications receiving 1841004 citations. The organization is also known as: UNICAMP & State University of Campinas.

Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery

Abstract: Lipids and lipid nanoparticles are extensively employed as oral-delivery systems for drugs and other active ingredients. These have been exploited for many features in the field of pharmaceutical technology. Lipids usually enhance drug absorption in the gastrointestinal tract (GIT), and when formulated as nanoparticles, these molecules improve mucosal adhesion due to small particle size and increasing their GIT residence time. In addition, lipid nanoparticles may also protect the loaded drugs from chemical and enzymatic degradation and gradually release drug molecules from the lipid matrix into blood, resulting in improved therapeutic profiles compared to free drug. Therefore, due to their physiological and biodegradable properties, lipid molecules may decrease adverse side effects and chronic toxicity of the drug-delivery systems when compared to other of polymeric nature. This paper highlights the importance of lipid nanoparticles to modify the release profile and the pharmacokinetic parameters of drugs when administrated through oral route.

Improved measurements of the neutrino mixing angle θ13 with the Double Chooz detector

Abstract: The Double Chooz experiment presents improved measurements of the neutrino mixing angle θ 13 using the data collected in 467.90 live days from a detector positioned at an average distance of 1050 m from two reactor cores at the Chooz nuclear power plant. Several novel techniques have been developed to achieve significant reductions of the backgrounds and systematic uncertainties with respect to previous publications, whereas the efficiency of the $$ {\overline{ u}}_e $$ signal has increased. The value of θ 13 is measured to be sin2 2θ 13 = 0.090 − 0.029 + 0.032 from a fit to the observed energy spectrum. Deviations from the reactor $$ {\overline{ u}}_e $$ prediction observed above a prompt signal energy of 4 MeV and possible explanations are also reported. A consistent value of θ 13 is obtained from a fit to the observed rate as a function of the reactor power independently of the spectrum shape and background estimation, demonstrating the robustness of the θ 13 measurement despite the observed distortion.