Institution
State University of Campinas
Education•Campinas, Brazil•
About: State University of Campinas is a education organization based out in Campinas, Brazil. It is known for research contribution in the topics: Population & Context (language use). The organization has 49454 authors who have published 104606 publications receiving 1841004 citations. The organization is also known as: UNICAMP & State University of Campinas.
Topics: Population, Context (language use), Medicine, Adsorption, Insulin
Papers published on a yearly basis
Papers
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TL;DR: This paper explores the nature of open set recognition and formalizes its definition as a constrained minimization problem, and introduces a novel “1-vs-set machine,” which sculpts a decision space from the marginal distances of a 1-class or binary SVM with a linear kernel.
Abstract: To date, almost all experimental evaluations of machine learning-based recognition algorithms in computer vision have taken the form of “closed set” recognition, whereby all testing classes are known at training time. A more realistic scenario for vision applications is “open set” recognition, where incomplete knowledge of the world is present at training time, and unknown classes can be submitted to an algorithm during testing. This paper explores the nature of open set recognition and formalizes its definition as a constrained minimization problem. The open set recognition problem is not well addressed by existing algorithms because it requires strong generalization. As a step toward a solution, we introduce a novel “1-vs-set machine,” which sculpts a decision space from the marginal distances of a 1-class or binary SVM with a linear kernel. This methodology applies to several different applications in computer vision where open set recognition is a challenging problem, including object recognition and face verification. We consider both in this work, with large scale cross-dataset experiments performed over the Caltech 256 and ImageNet sets, as well as face matching experiments performed over the Labeled Faces in the Wild set. The experiments highlight the effectiveness of machines adapted for open set evaluation compared to existing 1-class and binary SVMs for the same tasks.
1,029 citations
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TL;DR: Extracellular production of metal nanoparticles by several strains of the fungus Fusarium oxysporum was carried out in this paper, where it was found that aqueous silver ions when exposed to several FUSarium oxyssporum strains are reduced in solution, thereby leading to the formation of silver hydrosol.
Abstract: Extracellular production of metal nanoparticles by several strains of the fungus Fusarium oxysporum was carried out It was found that aqueous silver ions when exposed to several Fusarium oxysporum strains are reduced in solution, thereby leading to the formation of silver hydrosol The silver nanoparticles were in the range of 20–50 nm in dimensions The reduction of the metal ions occurs by a nitrate-dependent reductase and a shuttle quinone extracellular process The potentialities of this nanotechnological design based in fugal biosynthesis of nanoparticles for several technical applications are important, including their high potential as antibacterial material
1,025 citations
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TL;DR: Transplantation of both white and brown adipose tissue—brown especially—into ADicerKO mice restores the level of numerous circulating miRNAs that are associated with an improvement in glucose tolerance and a reduction in hepatic Fgf21 mRNA and circulating FGF21.
Abstract: Adipose tissue is a major site of energy storage and has a role in the regulation of metabolism through the release of adipokines. Here we show that mice with an adipose-tissue-specific knockout of the microRNA (miRNA)-processing enzyme Dicer (ADicerKO), as well as humans with lipodystrophy, exhibit a substantial decrease in levels of circulating exosomal miRNAs. Transplantation of both white and brown adipose tissue-brown especially-into ADicerKO mice restores the level of numerous circulating miRNAs that are associated with an improvement in glucose tolerance and a reduction in hepatic Fgf21 mRNA and circulating FGF21. This gene regulation can be mimicked by the administration of normal, but not ADicerKO, serum exosomes. Expression of a human-specific miRNA in the brown adipose tissue of one mouse in vivo can also regulate its 3' UTR reporter in the liver of another mouse through serum exosomal transfer. Thus, adipose tissue constitutes an important source of circulating exosomal miRNAs, which can regulate gene expression in distant tissues and thereby serve as a previously undescribed form of adipokine.
1,025 citations
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TL;DR: It is concluded that HL feeding induces a local proinflammatory status in the hypothalamus, which results in impaired anorexigenic insulin signaling, which leads to a reduced caloric intake and weight loss.
Abstract: Obesity has reached epidemic proportions in several regions of the world. General changes in lifestyle, including consumption of fat-rich food, are among the most important factors leading to an unprecedented increase in the prevalence of this disease. Weight gain results from an imbalance between caloric intake and energy expenditure. Both of these parameters are under the tight control of specialized neurons of the hypothalamus that respond to peripheral anorexigenic and adipostatic signals carried by leptin and insulin. Here we show, by macroarray analysis, that high-fat feeding [hyperlipidic diet (HL)] induces the expression of several proinflammatory cytokines and inflammatory responsive proteins in hypothalamus. This phenomenon is accompanied by increased activation of c-Jun N-terminal kinase and nuclear factor-κB. In addition, HL feeding leads to impaired functional and molecular activation of the insulin-signaling pathway, which is paralleled by increased serine phosphorylation of the insulin rece...
998 citations
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TL;DR: The current and future impact of multilocus nucleotide-sequence-based approaches to prokaryotic systematics are discussed and the potential, and difficulties, of assigning species status to biologically or ecologically meaningful sequence clusters are considered.
Abstract: There is no widely accepted concept of species for prokaryotes, and assignment of isolates to species is based on measures of phenotypic or genome similarity. The current methods for defining prokaryotic species are inadequate and incapable of keeping pace with the levels of diversity that are being uncovered in nature. Prokaryotic taxonomy is being influenced by advances in microbial population genetics, ecology and genomics, and by the ease with which sequence data can be obtained. Here, we review the classical approaches to prokaryotic species definition and discuss the current and future impact of multilocus nucleotide-sequence-based approaches to prokaryotic systematics. We also consider the potential, and difficulties, of assigning species status to biologically or ecologically meaningful sequence clusters.
989 citations
Authors
Showing all 49967 results
Name | H-index | Papers | Citations |
---|---|---|---|
David L. Kaplan | 177 | 1944 | 146082 |
Hyun-Chul Kim | 176 | 4076 | 183227 |
Carlos Escobar | 148 | 1184 | 95346 |
Maria Elena Pol | 139 | 1414 | 99240 |
Scott D. Solomon | 137 | 1145 | 103041 |
David H. Pashley | 137 | 740 | 63657 |
Wagner Carvalho | 135 | 1395 | 94184 |
Helio Nogima | 132 | 1274 | 84368 |
Manfred Jeitler | 132 | 1278 | 89645 |
Catherine Newman-Holmes | 129 | 914 | 75447 |
Guy A. Rouleau | 129 | 884 | 65892 |
João Carvalho | 126 | 1278 | 77017 |
Jochen Schieck | 124 | 1285 | 77822 |
F. Stuart Chapin | 123 | 375 | 86236 |
Jose Chinellato | 123 | 1116 | 64267 |