Institution
State University of Campinas
Education•Campinas, Brazil•
About: State University of Campinas is a education organization based out in Campinas, Brazil. It is known for research contribution in the topics: Population & Context (language use). The organization has 49454 authors who have published 104606 publications receiving 1841004 citations. The organization is also known as: UNICAMP & State University of Campinas.
Topics: Population, Context (language use), Medicine, Adsorption, Insulin
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the responses of photosynthetic gas exchange and chlorophyll fluorescence along with changes in carbohydrate and proline levels were studied in cowpea during water stress and recovery.
493 citations
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University of New Mexico1, Royal Children's Hospital2, Queen Mary University of London3, University of Helsinki4, Universidade Federal do Rio Grande do Sul5, Mexican Social Security Institute6, National Taiwan University7, Central Manchester University Hospitals NHS Foundation Trust8, State University of Campinas9, Telethon Institute for Child Health Research10, Chulalongkorn University11, University of the Philippines12, University of Alberta13, University of Manitoba14, University of Würzburg15, Katholieke Universiteit Leuven16, Dartmouth College17, University of Alabama at Birmingham18, GlaxoSmithKline19, University of Tampere20
TL;DR: Data from the end-of-study analysis of PATRICIA show cross-protective efficacy of the HPV-16/18 vaccine against four oncogenic non-vaccine HPV types-HPV-33, HPV-31, HPV -45, and HPV-51-in different trial cohorts representing diverse groups of women.
Abstract: Summary Background We evaluated the efficacy of the human papillomavirus HPV-16/18 AS04-adjuvanted vaccine against non-vaccine oncogenic HPV types in the end-of-study analysis after 4 years of follow-up in PATRICIA (PApilloma TRIal against Cancer In young Adults) Methods Healthy women aged 15–25 years with no more than six lifetime sexual partners were included in PATRICIA irrespective of their baseline HPV DNA status, HPV-16 or HPV-18 serostatus, or cytology Women were randomly assigned (1:1) to HPV-16/18 vaccine or a control hepatitis A vaccine, via an internet-based central randomisation system using a minimisation algorithm to account for age ranges and study sites The study was double-blind The primary endpoint of PATRICIA has been reported previously; the present analysis evaluates cross-protective vaccine efficacy against non-vaccine oncogenic HPV types in the end-of-study analysis Analyses were done for three cohorts: the according-to-protocol cohort for efficacy (ATP-E; vaccine n=8067, control n=8047), total vaccinated HPV-naive cohort (TVC-naive; no evidence of infection with 14 oncogenic HPV types at baseline, approximating young adolescents before sexual debut; vaccine n=5824, control n=5820), and the total vaccinated cohort (TVC; all women who received at least one vaccine dose, approximating catch-up populations that include sexually active women; vaccine n=9319, control=9325) Vaccine efficacy was evaluated against 6-month persistent infection, cervical intraepithelial neoplasia grade 2 or greater (CIN2+) associated with 12 non-vaccine HPV types (individually or as composite endpoints), and CIN3+ associated with the composite of 12 non-vaccine HPV types This study is registered with ClinicalTrialsgov, number NCT00122681 Findings Consistent vaccine efficacy against persistent infection and CIN2+ (with or without HPV-16/18 co-infection) was seen across cohorts for HPV-33, HPV-31, HPV-45, and HPV-51 In the most conservative analysis of vaccine efficacy against CIN2+, where all cases co-infected with HPV-16/18 were removed, vaccine efficacy was noted for HPV-33 in all cohorts, and for HPV-31 in the ATP-E and TVC-naive Vaccine efficacy against CIN2+ associated with the composite of 12 non-vaccine HPV types (31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68), with or without HPV-16/18 co-infection, was 46·8% (95% CI 30·7–59·4) in the ATP-E, 56·2% (37·2–69·9) in the TVC-naive, and 34·2% (20·4–45·8) in the TVC Corresponding values for CIN3+ were 73·8% (48·3–87·9), 91·4% (65·0–99·0), and 47·5% (22·8–64·8) Interpretation Data from the end-of-study analysis of PATRICIA show cross-protective efficacy of the HPV-16/18 vaccine against four oncogenic non-vaccine HPV types—HPV-33, HPV-31, HPV-45, and HPV-51—in different trial cohorts representing diverse groups of women Funding GlaxoSmithKline Biologicals
488 citations
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TL;DR: Results indicate that AtALMT1 is an essential factor for Al tolerance in Arabidopsis but does not represent the major Al tolerance QTL also found on chromosome 1.
Abstract: Aluminum (Al) tolerance in Arabidopsis is a genetically complex trait, yet it is mediated by a single physiological mechanism based on Al-activated root malate efflux. We investigated a possible molecular determinant for Al tolerance involving a homolog of the wheat Al-activated malate transporter, ALMT1. This gene, named AtALMT1 (At1g08430), was the best candidate from the 14-memberAtALMT family to be involved with Al tolerance based on expression patterns and genomic location. Physiological analysis of a transferred DNA knockout mutant for AtALMT1 as well as electrophysiological examination of the protein expressed in Xenopus oocytes showed that AtALMT1 is critical for Arabidopsis Al tolerance and encodes the Al-activated root malate efflux transporter associated with tolerance. However, gene expression and sequence analysis of AtALMT1 alleles from tolerant Columbia (Col), sensitive Landsberg erecta (Ler), and other ecotypes that varied in Al tolerance suggested that variation observed at AtALMT1 is not correlated with the differences observed in Al tolerance among these ecotypes. Genetic complementation experiments indicated that the Ler allele of AtALMT1 is equally effective as the Col allele in conferring Al tolerance and Al-activated malate release. Finally, fine-scale mapping of a quantitative trait locus (QTL) for Al tolerance on chromosome 1 indicated that AtALMT1 is located proximal to this QTL. These results indicate that AtALMT1 is an essential factor for Al tolerance in Arabidopsis but does not represent the major Al tolerance QTL also found on chromosome 1.
488 citations
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04 Mar 2013
TL;DR: In this paper, the authors measured the transverse-momentum (p(T)) distributions and yields of pi, K, and p in Pb-Pb collisions at root s(NN) = 2.76 TeV.
Abstract: In this paper measurements are presented of pi(+/-), K-+/-, p, and (p) over bar production at midrapidity (vertical bar y vertical bar < 0.5), in Pb-Pb collisions at root s(NN) = 2.76 TeV as a function of centrality. The measurement covers the transverse-momentum (p(T)) range from 100, 200, and 300 MeV/c up to 3, 3, and 4.6 GeV/c for pi, K, and p, respectively. The measured p(T) distributions and yields are compared to expectations based on hydrodynamic, thermal and recombination models. The spectral shapes of central collisions show a stronger radial flow than measured at lower energies, which can be described in hydrodynamic models. In peripheral collisions, the p(T) distributions are not well reproduced by hydrodynamic models. Ratios of integrated particle yields are found to be nearly independent of centrality. The yield of protons normalized to pions is a factor similar to 1.5 lower than the expectation from thermal models.
485 citations
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TL;DR: In this article, a new fractional derivative with respect to another function is introduced, the so-called ψ-Hilfer fractional derivatives, which can be used to obtain uniformly convergent sequence of function, uniformly continuous function and examples including the Mittag-Leffler function with one parameter.
485 citations
Authors
Showing all 49967 results
Name | H-index | Papers | Citations |
---|---|---|---|
David L. Kaplan | 177 | 1944 | 146082 |
Hyun-Chul Kim | 176 | 4076 | 183227 |
Carlos Escobar | 148 | 1184 | 95346 |
Maria Elena Pol | 139 | 1414 | 99240 |
Scott D. Solomon | 137 | 1145 | 103041 |
David H. Pashley | 137 | 740 | 63657 |
Wagner Carvalho | 135 | 1395 | 94184 |
Helio Nogima | 132 | 1274 | 84368 |
Manfred Jeitler | 132 | 1278 | 89645 |
Catherine Newman-Holmes | 129 | 914 | 75447 |
Guy A. Rouleau | 129 | 884 | 65892 |
João Carvalho | 126 | 1278 | 77017 |
Jochen Schieck | 124 | 1285 | 77822 |
F. Stuart Chapin | 123 | 375 | 86236 |
Jose Chinellato | 123 | 1116 | 64267 |