Institution
Taipei Veterans General Hospital
Healthcare•Taipei, Taiwan•
About: Taipei Veterans General Hospital is a healthcare organization based out in Taipei, Taiwan. It is known for research contribution in the topics: Population & Cancer. The organization has 11878 authors who have published 16478 publications receiving 363424 citations. The organization is also known as: Táiběi Róngmín Zǒngyī Yuàn.
Topics: Population, Cancer, Medicine, Hazard ratio, Atrial fibrillation
Papers published on a yearly basis
Papers
More filters
••
TL;DR: The results showed preconditioning by one-dose HBO protects rat liver against subsequent ischemia-reperfusion injury.
89 citations
••
TL;DR: Volume-staged SRS affords higher obliteration rates and similar complication rates compared with dose-staging SRS, and may be a superior approach for large AVMs that are not amenable to single-session SRS.
Abstract: Object The aim in this paper was to compare the outcomes of dose-staged and volume-staged stereotactic radio-surgery (SRS) in the treatment of large (> 10 cm3) arteriovenous malformations (AVMs). Methods A systematic literature review was performed using PubMed. Studies written in the English language with at least 5 patients harboring large (> 10 cm3) AVMs treated with dose- or volume-staged SRS that reported post-treatment outcomes data were selected for review. Demographic information, radiosurgical treatment parameters, and post-SRS outcomes and complications were analyzed for each of these studies. Results The mean complete obliteration rates for the dose- and volume-staged groups were 22.8% and 47.5%, respectively. Complete obliteration was demonstrated in 30 of 161 (18.6%) and 59 of 120 (49.2%) patients in the dose- and volume-staged groups, respectively. The mean rates of symptomatic radiation-induced changes were 13.5% and 13.6% in dose- and volume-staged groups, respectively. The mean rates of c...
89 citations
••
TL;DR: Long-term consumption of red wine and white wine inhibits MCP-1 expression, and in the small number of animals studied, red wine modestly reduces neointimal hyperplasia.
Abstract: Background—Wine consumption decreases the risk of myocardial infarction. Intimal hyperplasia contributes to restenosis after angioplasty. Local ethanol delivery inhibits intimal hyperplasia after balloon injury in rabbit iliac and pig coronary arteries. The effects of wine consumption on intimal response and monocyte chemotactic protein-1 (MCP-1) expression were studied in cholesterol-fed rabbits. Methods and Results—Male rabbits were fed a 2% cholesterol diet together with red wine (12.5% vol, 5 mL/kg body wt per day; n=7), white wine (13.3% vol, 5 mL/kg body wt per day; n=7), or no wine as a control (n=8) for 6 weeks. A balloon injury of the abdominal aorta was performed at the end of the third week. Abdominal aortas were harvested at the end of 6 weeks. Neointimal hyperplasia was measured morphometrically. MCP-1 expression was determined by Northern blot, in situ hybridization, and immunohistochemistry. Rabbits fed red wine had significantly less neointimal hyperplasia than did control rabbits (intima/...
89 citations
••
TL;DR: It is likely that early endoscopy (≤ 12 h) is associated with a better outcome in hematemesis patients, but a randomized trial with larger case numbers is required before making a firm conclusion.
89 citations
••
TL;DR: The study shows that concurrent sorafenib and TACE therapy is safe and effective with no unexpected side effects.
Abstract: Transarterial chemoembolization (TACE) represents a first-line noncurative therapy for hepatocellular carcinoma (HCC). Sorafenib, a multikinase inhibitor, has been shown to be effective and safe monotherapy in patients with advanced HCC and the current study reports the interim results of a prospective Phase II, open label, trial investigating the safety and efficacy of the combination of sorafenib and conventional TACE in patients from the Asia-Pacific region with intermediate HCC. Patients with histologically or clinically diagnosed HCC were treated with conventional TACE followed by sorafenib 4 to 7 days later. TACE was performed by selective transarterial chemotherapy in the vessels feeding the tumor with an emulsion of lipiodol (5-20 ml) and doxorubicin (30-60 mg) followed by embolization with absorbable particles (gel foam). TACE/sorafenib cycles were repeated every 6-8 weeks. Primary objectives were to evaluate the safety and tolerability, in addition to the efficacy of TACE combined with sorafenib for HCC. A total of 147 patients were included in the intention-to-treat analysis and received at least one dose of sorafenib. Gastrointestinal AEs were reported by 62.6% of patients while 57.8% reported skin AEs although most were mild to moderate. The mean number of cycles undertaken was 2.1 and 63.3% of patients achieved either partial response or stable disease. Clinically, the disease control rate was 91.2% while the overall response rate was calculated as 52.4%. Our study shows that concurrent sorafenib and TACE therapy is safe and effective with no unexpected side effects.
89 citations
Authors
Showing all 11952 results
Name | H-index | Papers | Citations |
---|---|---|---|
Peng Huang | 95 | 590 | 39098 |
Hui Y. Lan | 86 | 248 | 23383 |
Yau-Huei Wei | 78 | 385 | 22286 |
Chunyu Liu | 76 | 450 | 26738 |
Ching-Yu Cheng | 75 | 541 | 39780 |
Shou-Dong Lee | 75 | 788 | 26066 |
Shih Ann Chen | 73 | 698 | 28441 |
Shuu Jiun Wang | 71 | 502 | 24800 |
Pesus Chou | 65 | 481 | 16907 |
Jong Ling Fuh | 65 | 383 | 19559 |
Shing Jong Lin | 63 | 401 | 13236 |
Charles Y. Chiu | 62 | 236 | 13185 |
Bor-Luen Chiang | 60 | 460 | 13597 |
Tzeng Ji Chen | 60 | 541 | 13644 |
Shih Hwa Chiou | 58 | 262 | 12289 |