Institution
Texas Medical Center
Healthcare•Houston, Texas, United States•
About: Texas Medical Center is a healthcare organization based out in Houston, Texas, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 2845 authors who have published 2394 publications receiving 79426 citations.
Topics: Population, Cancer, Stroke, Gene, Health care
Papers published on a yearly basis
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TL;DR: These mutations provide evidence that different mechanisms can result in galactosemia: destabilizing mutations in any given area of the protein and missense mutations in conserved domains of the enzyme resulting in low or no activity.
28 citations
Journal Article•
TL;DR: In this paper, the authors studied the use of biomolecules described as possible diagnostic or clinically prognostic markers in the context of melanoma disease progression as measured by the gold standards of tumor thickness and development of metastasis and showed variations in expression phenotype only during the deeply invasive or metastatic stage of tumor progression and were thus predictive of clinical outcome only for these subgroups of patients.
28 citations
TL;DR: Isometric twitch characteristics and biochemical parameters of isolated myosin and sarcoplasmic reticulum have been compared in three cat hind limb muscles and when fit to a two component model, the caudofemoralis SR exhibits a higher amount of a fast binding site than does soleus SR, features reflected in differences in the relaxation time of the two muscles.
Abstract: Isometric twitch characteristics and biochemical parameters of isolated myosin and sarcoplasmic reticulum have been compared in three cat hind limb muscles. The fast twitch caudofemoralis and the slow twitch soleus are almost pure muscles as judged from histochemical studies. Isolated myosin from the caudofemoralis is not only 2- to 3-fold higher in its ATPase activities than that of the soleus, but also in non-dissociated forms has greater electrophoretic mobility than the soleus myosin. Purified myosins from fast muscles as well as soleus exhibited three light chains upon electrophoresis. However, the intact non-solubilized myosins differed in electrophoretic mobilities. The sarcoplasmic reticulum fraction isolated from caudfemoralis exhibits faster rates of Ca++ binding and uptake than soleus, and when fit to a two component model, the caudofemoralis SR exhibits a higher amount of a fast binding site than does soleus SR, features reflected in differences in the relaxation time of the two muscles.
In contrast, the fast twitch tibialis anterior has been shown to be a gradient of fiber types and its isometric twitch may be separated by selective nerve stimulation, into a fast and a slow twitch component. Our findings that myosin fraction, as well as sarcoplasmic reticulum fractions isolated from these two components differ with respect to their biochemical characteristics add support to the possibility of a dual function in this muscle.
28 citations
TL;DR: The study found that elderly patients with relatively poor perception of mental health and utilization of antipsychotic agents after 1998 (enabling) were more likely to involve the use of atypical agents.
Abstract: Objectives: This study examined the determinants of atypical antipsychotic use among antipsychotic users in community-dwelling elderly in the United States.Methods: The study involved analysis of household and prescription files of the Medical Expenditure Panel Survey (MEPS) data from 1996 to 2004. The analysis focused on the use of six atypical antipsychotic agents namely, clozapine, olanzapine, risperidone, quetiapine, ziprasidone, and aripiprazole among the elderly of 60 years or older. Multiple logistic regression analysis within the conceptual framework of Andersen's Behavioral Model was used to examine the determinants of atypical antipsychotic use among antipsychotic users in community-dwelling elderly.Results: An average of 0.62 million elderly received antipsychotic agents annually during the study period. A majority of the elderly using antipsychotic agents were female (70%), white (86%), non-Hispanic (95%), and living in metropolitan statistical areas (79%). Frequently reported diagnose...
28 citations
TL;DR: Based on experience, simple cyst of the testis should be suspected particularly in an enlarged but otherwise palpably normal testis, and symptomaticsimple cyst should be treated ideally with local parenchyma-sparing excision.
28 citations
Authors
Showing all 2878 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Eric N. Olson | 206 | 814 | 144586 |
| Scott M. Grundy | 187 | 841 | 231821 |
| Joseph Jankovic | 153 | 1146 | 93840 |
| Geoffrey Burnstock | 141 | 1488 | 99525 |
| George Perry | 139 | 923 | 77721 |
| David Y. Graham | 138 | 1047 | 80886 |
| James R. Lupski | 136 | 844 | 74256 |
| Savio L. C. Woo | 135 | 785 | 62270 |
| Henry T. Lynch | 133 | 925 | 86270 |
| Joseph P. Broderick | 130 | 504 | 72779 |
| Huda Y. Zoghbi | 127 | 463 | 65169 |
| Paul M. Vanhoutte | 127 | 868 | 62177 |
| Meletios A. Dimopoulos | 122 | 1371 | 71871 |
| John B. Holcomb | 120 | 733 | 53760 |
| John S. Mattick | 116 | 367 | 64315 |