Texas Medical Center

About: Texas Medical Center is a healthcare organization based out in Houston, Texas, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 2845 authors who have published 2394 publications receiving 79426 citations.

Effect of undernutrition on amino acid compartmentation in the developing rat brain

Abstract: —Rat pups undernourished through 21 days of age show abnormal patterns of cerebral amino acid metabolism. The pattern of incorporation of radioactivity from l-[U-14C]leucine into amino acids derived from tricarboxylic acid cycle intermediates was altered, with significantly more 14C being incorporated into glutamate and aspartate in the underfed rats than in controls. Glutamate compartmentation, manifested in the ratio of specific radioactivities of glutamine to glutamate, developed more slowly in the. diet-restricted group. These results are similar to those seen in neonatally-thyroidectomized rats and suggest decreased growth of neuronal processes. This impairment of amino acid metabolism returns to normal after a 7-week period of adequate nutrition.

The measurement of respiratory volumes in animals and man with use of electrical impedance

Abstract: The use of electrical impedance to measure respiration is based upon the close correlation found experimentally between changes in the respired volume and changes in transthoracic impedance. The method is elegant in its simplicity, requiring only the application of two or four electrodes to the surface of the thorax. This technique does not require direct contact with the airstream, and hence does not impose any restriction on breathing; neither does it impose restrictions on body movements as do many volume-determining devices such as spirometers and pneumotachometers. The method requires that a low-intensity high-frequency current be caused to flow through the thorax. This current may be applied directly by means of surface electrodes or may be a displacement current if the thorax is used as a dielectric between two capacitor plates. This latter technique is more difficult to apply. In practice, in order to detect the impedance change, either two or four electrodes are placed in direct contact with the thorax. Spirometry by the impedance method has received attention in recent years in the growing demand for the means of acquiring physiological data by noninvasive methods. Presently, its possible use in multiphasic screening programs is being investigated. It is the purpose of this paper to review briefly the work that has been reported in this field, emphasizing the latest studies that have been conducted in the authors’ laboratory.

Impact of Initial Imaging Protocol on Likelihood of Endovascular Stroke Therapy.

Abstract: Background and Purpose: Noncontrast head CT and CT perfusion (CTP) are both used to screen for endovascular stroke therapy (EST), but the impact of imaging strategy on likelihood of EST is undeterm...