Showing papers by "University of Cyprus published in 2012"

Normalization of Tumour Blood Vessels Improves the Delivery of Nanomedicines in a Size-Dependent Manner

Abstract: The blood vessels of cancerous tumours are leaky and poorly organized. This can increase the interstitial fluid pressure inside tumours and reduce blood supply to them, which impairs drug delivery. Anti-angiogenic therapies--which 'normalize' the abnormal blood vessels in tumours by making them less leaky--have been shown to improve the delivery and effectiveness of chemotherapeutics with low molecular weights, but it remains unclear whether normalizing tumour vessels can improve the delivery of nanomedicines. Here, we show that repairing the abnormal vessels in mammary tumours, by blocking vascular endothelial growth factor receptor-2, improves the delivery of smaller nanoparticles (diameter, 12 nm) while hindering the delivery of larger nanoparticles (diameter, 125 nm). Using a mathematical model, we show that reducing the sizes of pores in the walls of vessels through normalization decreases the interstitial fluid pressure in tumours, thus allowing small nanoparticles to enter them more rapidly. However, increased steric and hydrodynamic hindrances, also associated with smaller pores, make it more difficult for large nanoparticles to enter tumours. Our results further suggest that smaller (∼12 nm) nanomedicines are ideal for cancer therapy due to their superior tumour penetration.

Combined results of searches for the standard model Higgs boson in pp collisions at √s = 7 TeV

Abstract: Combined results are reported from searches for the standard model Higgs boson in proton-proton collisions at sqrt(s)=7 TeV in five Higgs boson decay modes: gamma pair, b-quark pair, tau lepton pair, W pair, and Z pair. The explored Higgs boson mass range is 110-600 GeV. The analysed data correspond to an integrated luminosity of 4.6-4.8 inverse femtobarns. The expected excluded mass range in the absence of the standard model Higgs boson is 118-543 GeV at 95% CL. The observed results exclude the standard model Higgs boson in the mass range 127-600 GeV at 95% CL, and in the mass range 129-525 GeV at 99% CL. An excess of events above the expected standard model background is observed at the low end of the explored mass range making the observed limits weaker than expected in the absence of a signal. The largest excess, with a local significance of 3.1 sigma, is observed for a Higgs boson mass hypothesis of 124 GeV. The global significance of observing an excess with a local significance greater than 3.1 sigma anywhere in the search range 110-600 (110-145) GeV is estimated to be 1.5 sigma (2.1 sigma). More data are required to ascertain the origin of this excess.

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

Abstract: The blood vessels of cancerous tumours are leaky and poorly organized. This can increase the interstitial fluid pressure inside tumours and reduce blood supply to them, which impairs drug delivery. Anti-angiogenic therapies--which 'normalize' the abnormal blood vessels in tumours by making them less leaky--have been shown to improve the delivery and effectiveness of chemotherapeutics with low molecular weights, but it remains unclear whether normalizing tumour vessels can improve the delivery of nanomedicines. Here, we show that repairing the abnormal vessels in mammary tumours, by blocking vascular endothelial growth factor receptor-2, improves the delivery of smaller nanoparticles (diameter, 12 nm) while hindering the delivery of larger nanoparticles (diameter, 125 nm). Using a mathematical model, we show that reducing the sizes of pores in the walls of vessels through normalization decreases the interstitial fluid pressure in tumours, thus allowing small nanoparticles to enter them more rapidly. However, increased steric and hydrodynamic hindrances, also associated with smaller pores, make it more difficult for large nanoparticles to enter tumours. Our results further suggest that smaller (∼12 nm) nanomedicines are ideal for cancer therapy due to their superior tumour penetration.

Command Filtered Adaptive Backstepping

Abstract: Implementation of adaptive backstepping controllers requires analytic calculation of the partial derivatives of certain stabilizing functions. It is well documented that, as the order of a nonlinear system increases, analytic calculation of these derivatives becomes prohibitive. Therefore, in practice, either alternative control approaches are used or the derivatives are neglected in the implementation. Neglecting the derivatives results in the loss of all guarantees proven by Lyapunov methods for the adaptive backstepping approach and may result in instability. This paper presents a new implementation approach for adaptive backstepping control. The main objectives are to facilitate the derivation and implementation of the adaptive backstepping approach, with performance guarantees proven by Lyapunov methods, for applications that were prohibitively difficult using the standard analytic implementation approach. The new approach uses filtering methods to produce certain command signals and their derivatives which eliminates the requirement of analytic differentiation. The approach also introduces filters to generate certain compensating signals necessary to compute compensated tracking errors suitable for adaptive parameter estimation. We present a set of Lemmas and Theorems to analyze the performance both during the initialization and the operating phases. We show that the initialization phase is of finite duration that can be controlled by selection of a design parameter. We also show that all signals within the system are bounded during this short initialization phase. During the operating phase, we show that the command filtered implementation approach has theoretical properties identical to those of the conventional approach. The general approach is presented and analyzed for systems in generalized parameter strict feedback form. Extensions of the approach are presented to demonstrate the application of the method to a land vehicle trajectory following application. Application and effectiveness of the proposed method is shown by simulation results.

Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV

Abstract: The performance of muon reconstruction, identification, and triggering in CMS has been studied using 40 inverse picobarns of data collected in pp collisions at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection criteria covering a wide range of physics analysis needs have been examined. For all considered selections, the efficiency to reconstruct and identify a muon with a transverse momentum pT larger than a few GeV is above 95% over the whole region of pseudorapidity covered by the CMS muon system, abs(eta)<2.4, while the probability to misidentify a hadron as a muon is well below 1%. The efficiency to trigger on single muons with pT above a few GeV is higher than 90% over the full eta range, and typically substantially better. The overall momentum scale is measured to a precision of 0.2% with muons from Z decays. The transverse momentum resolution varies from 1% to 6% depending on pseudorapidity for muons with pT below 100 GeV and, using cosmic rays, it is shown to be better than 10% in the central region up to pT = 1 TeV. Observed distributions of all quantities are well reproduced by the Monte Carlo simulation.

Study of high-p(T) charged particle suppression in PbPb compared to pp collisions at root s(NN)=2.76 TeV

Abstract: The transverse momentum spectra of charged particles have been measured in pp and PbPb collisions at sqrt(sNN) = 2.76 TeV by the CMS experiment at the LHC. In the transverse momentum range pt = 5-10 GeV/c, the charged particle yield in the most central PbPb collisions is suppressed by up to a factor of 5 compared to the pp yield scaled by the number of incoherent nucleon-nucleon collisions. At higher pt, this suppression is significantly reduced, approaching roughly a factor of 2 for particles with pt in the range pt=40-100 GeV/c.

Detection of epileptic electroencephalogram based on Permutation Entropy and Support Vector Machines

Abstract: The electroencephalogram (EEG) has proven a valuable tool in the study and detection of epilepsy. This paper investigates for the first time the use of Permutation Entropy (PE) as a feature for automated epileptic seizure detection. A Support Vector Machine (SVM) is used to classify segments of normal and epileptic EEG based on PE values. The proposed system utilizes the fact that the EEG during epileptic seizures is characterized by lower PE than normal EEG. It is shown that average sensitivity of 94.38% and average specificity of 93.23% is obtained by using PE as a feature to characterize epileptic and seizure-free EEG, while 100% sensitivity and specificity were also obtained in single-trial classifications.

Crowdsourcing with Smartphones

Abstract: Smartphones can reveal crowdsourcing's full potential and let users transparently contribute to complex and novel problem solving. This emerging area is illustrated through a taxonomy that classifies the mobile crowdsourcing field and through three new applications that optimize location-based search and similarity services based on crowd-generated data. Such applications can be deployed on SmartLab, a cloud of more than 40 Android devices deployed at the University of Cyprus that provides an open testbed to facilitate research and development of smartphone applications on a massive scale.

A longitudinal study of cyberbullying: Examining riskand protective factors

Abstract: The objective of the current study was to examine possible risk (school-bullying and victimization, exposure to media violence, callous-unemotional traits, impulsivity and narcissism) and protective (family, peer and school social support) factors that might be associated with cyberbullying and cyber-victimization by employing a longitudinal, two-wave design. The sample consisted of 1,416 (50.1% girls) adolescents living in Cyprus. The findings suggested cross-sectional and longitudinal associations between school-bullying and cyberbullying and between school-victimization and cyber-victimization. Furthermore, callous-unemotional traits were longitudinally related to cyberbullying. Media violence exposure was a risk factor leading to both cyberbullying and cyber-victimization, while family social support was a protective factor for both types of adjustment problems. Finally, family social support protected adolescents living in single-parent households from being cyber-victimized when their friendships we...

Full-Duplex Relay Selection for Amplify-and-Forward Cooperative Networks

Abstract: This paper focuses on the relay selection problem in amplify-and-forward (AF) cooperative communication with full-duplex (FD) operation. Different relay selection schemes assuming the availability of different instantaneous information are studied. We consider optimal relay selection that maximizes the instantaneous FD channel capacity and requires global channel state information (CSI) as well as several sub-optimal relay selection policies that utilize partial CSI knowledge such as a) source-relay and relay-destination links b) loop interference c) source-relay links and loop interference. To facilitate comparison, exact outage probability expressions and asymptotic approximations of these policies that show a zero diversity order are derived. In addition, an optimal relay selection procedure that incorporates a hybrid relaying strategy, which dynamically switches between FD and half-duplex relaying according to the instantaneous CSI, is also investigated.

RF Energy Transfer for Cooperative Networks: Data Relaying or Energy Harvesting?

Abstract: This letter deals with a three-node cooperative network where the relay node harvests energy from radio frequency (RF) radiation. The source node is the only available RF generator and introduces a fundamental switching between energy harvesting and data relaying. A greedy switching (GS) policy where the relay node transmits when its residual energy ensures decoding at the destination is investigated. The GS policy is modeled as a Markov chain for a discretized battery; the stationary distribution and the outage probability of the system are derived in closed form expressions. In addition, an optimal switching policy that incorporates a-priori knowledge of the channel coefficients is proposed and solved by a mixed-integer linear programming formulation.

An EFSUMB introduction into Dynamic Contrast-Enhanced Ultrasound (DCE-US) for quantification of tumour perfusion.

Abstract: Dynamic Contrast Enhanced Ultrasound (DCE-US) is an imaging technique that utilizes microbubble contrast agents in diagnostic ultrasound. The EFSUMB guidelines published in 2004, updated in 2008 and 2011 focused on the use of DCE-US, including essential technical requirements, training, investigational procedures and steps, guidance on image interpretation, established and recommended clinical indications and safety considerations. However the quantification of images acquired with ultrasound contrast agents (UCAs) is not discussed in the guidelines. The purpose of this EFSUMB document is to provide some recommendations and descriptions of the quantification of ultrasound images, technical requirements for analysis of time-intensity curves (TICs), methodology for data analysis, and interpretation of the results.

When Rater Reliability Is Not Enough Teacher Observation Systems and a Case for the Generalizability Study

Abstract: >> In recent years, interest has grown in using classroom observation as a means to several ends, including teacher development, teacher evaluation, and impact evaluation of classroom-based interven tions. Although education practitioners and researchers have developed numerous observational instruments for these pur poses, many developers fail to specify important criteria regarding instrument use. In this article, the authors argue that for classroom observation to succeed in its aims, improved observational systems must be developed. These systems should include not only obser vational instruments but also scoring designs capable of producing reliable and cost-efficient scores and processes for rater recruit ment, training, and certification. To illustrate how such a system might be developed and improved, the authors provide an empirical example that applies generalizability theory to data from a mathe matics observational instrument.

Observation of sequential Υ suppression in PbPb collisions

Abstract: The suppression of the individual Υ(nS) states in PbPb collisions with respect to their yields in pp data has been measured. The PbPb and pp data sets used in the analysis correspond to integrated luminosities of 150 μb^(-1) and 230 nb^(-1), respectively, collected in 2011 by the CMS experiment at the LHC, at a center-of-mass energy per nucleon pair of 2.76 TeV. The Υ(nS) yields are measured from the dimuon invariant mass spectra. The suppression of the Υ(nS) yields in PbPb relative to the yields in pp, scaled by the number of nucleon-nucleon collisions, R_(AA), is measured as a function of the collision centrality. Integrated over centrality, the R_(AA) values are 0.56±0.08(stat)±0.07(syst), 0.12±0.04(stat)±0.02(syst), and lower than 0.10 (at 95% confidence level), for the Υ(1S), Υ(2S), and Υ(3S) states, respectively. The results demonstrate the sequential suppression of the Υ(nS) states in PbPb collisions at LHC energies.

Jet momentum dependence of jet quenching in PbPb collisions at sNN=2.76 TeV

Abstract: Dijet production in PbPb collisions at a nucleon–nucleon center-of-mass energy of 276 TeV is studied with the CMS detector at the LHC A data sample corresponding to an integrated luminosity of 150 μb−1 is analyzed Jets are reconstructed using combined information from tracking and calorimetry, using the anti-kT algorithm with R=03 The dijet momentum balance and angular correlations are studied as a function of collision centrality and leading jet transverse momentum For the most peripheral PbPb collisions, good agreement of the dijet momentum balance distributions with pp data and reference calculations at the same collision energy is found, while more central collisions show a strong imbalance of leading and subleading jet transverse momenta attributed to the jet-quenching effect The dijets in central collisions are found to be more unbalanced than the reference, for leading jet transverse momenta up to the highest values studied

Suppression of non-prompt J/ψ, prompt J/ψ, and Y(1S) in PbPb collisions at √s NN = 2.76 TeV

Abstract: Yields of prompt and non-prompt J/psi, as well as Y(1S) mesons, are measured by the CMS experiment via their dimuon decays in PbPb and pp collisions at sqrt(sNN) = 2.76 TeV for quarkonium rapidity |y|<2.4. Differential cross sections and nuclear modification factors are reported as functions of y and transverse momentum pt, as well as collision centrality. For prompt J/psi with relatively high pt (6.5

Search for dark matter and large extra dimensions in monojet events in pp collisions at √s = 7 TeV

Abstract: A search has been made for events containing an energetic jet and an imbalance in transverse momentum using a data sample of pp collisions at a center-of-mass energy of 7 TeV. This signature is common to both dark matter and extra dimensions models. The data were collected by the CMS detector at the LHC and correspond to an integrated luminosity of 5.0 inverse femtobarns. The number of observed events is consistent with the standard model expectation. Constraints on the dark matter-nucleon scattering cross sections are determined for both spin-independent and spin-dependent interaction models. For the spin-independent model, these are the most constraining limits for a dark matter particle with mass below 3.5 GeV, a region unexplored by direct detection experiments. For the spin-dependent model, these are the most stringent constraints over the 0.1-200 GeV mass range. The constraints on the Arkani-Hamed, Dimopoulos, and Dvali model parameter MD determined as a function of the number of extra dimensions are also an improvement over the previous results.

Search for the standard model Higgs boson decaying into two photons in pp collisions at s=7TeV

Abstract: A search for a Higgs boson decaying into two photons is described. The analysis is performed using a dataset recorded by the CMS experiment at the LHC from pp collisions at a centre-of-mass energy of 7 TeV, which corresponds to an integrated luminosity of 4.8 inverse femtobarns. Limits are set on the cross section of the standard model Higgs boson decaying to two photons. The expected exclusion limit at 95% confidence level is between 1.4 and 2.4 times the standard model cross section in the mass range between 110 and 150 GeV. The analysis of the data excludes, at 95% confidence level, the standard model Higgs boson decaying into two photons in the mass range 128 to 132 GeV. The largest excess of events above the expected standard model background is observed for a Higgs boson mass hypothesis of 124 GeV with a local significance of 3.1 sigma. The global significance of observing an excess with a local significance greater than 3.1 sigma anywhere in the search range 110-150 GeV is estimated to be 1.8 sigma. More data are required to ascertain the origin of this excess.

Blending Physical and Virtual Manipulatives: An Effort to Improve Students' Conceptual Understanding through Science Laboratory Experimentation

Abstract: This study aimed to investigate the effect of experimenting with physical manipulatives (PM), virtual manipulatives (VM), and a blended combination of PM and VM on undergraduate students' understanding of concepts in the domain of Light and Color. A pre–post comparison study design was used for the purposes of this study that involved 70 participants assigned to three conditions. The first condition consisted of 23 students that used PM, the second condition consisted of 23 students that used VM, and the third condition consisted of 24 students that used the blended combination of PM and VM. In the case of the blended combination, the use of VM or PM was selected based on whether it provides an affordance that the other medium of experimentation (PM or VM) cannot provide. All conditions used the same inquiry-oriented curriculum materials and procedures. Conceptual tests were administered to assess students' understanding before, during, and after teaching. Results revealed that the use of a blended combination of PM and VM enhanced students' conceptual understanding in the domain of Light and Color more than the use of PM or VM alone. © 2011 Wiley Periodicals, Inc. Sci Ed96:21–47, 2012

Distributed Fault Detection and Isolation of Large-Scale Discrete-Time Nonlinear Systems: An Adaptive Approximation Approach

Abstract: This paper deals with the problem of designing a distributed fault detection and isolation methodology for nonlinear uncertain large-scale discrete-time dynamical systems. As a divide et impera approach is used to overcome the scalability issues of a centralized implementation, the large scale system being monitored is modelled as the interconnection of several subsystems. The subsystems are allowed to overlap, thus sharing some state components. For each subsystem, a Local Fault Diagnoser is designed, based on the measured local state of the subsystem as well as the transmitted variables of neighboring states that define the subsystem interconnections. The local diagnostic decision is made on the basis of the knowledge of the local subsystem dynamic model and of an adaptive approximation of the interconnection with neighboring subsystems. The use of a specially-designed consensus-based estimator is proposed in order to improve the detectability and isolability of faults affecting variables shared among overlapping subsystems. Theoretical results are provided to characterize the detection and isolation capabilities of the proposed distributed scheme. Finally, simulation results are reported showing the effectiveness of the proposed methodology.

Study of the inclusive production of charged pions, kaons, and protons in pp collisions at √s = 0.9,2.76 and 7 TeV

Abstract: Spectra of identified charged hadrons are measured in pp collisions at the LHC for sqrt(s) = 0.9, 2.76, and 7 TeV. Charged pions, kaons, and protons in the transverse-momentum range pt approximately 0.1-1.7 GeV and for rapidities abs(y) < 1 are identified via their energy loss in the CMS silicon tracker. The average pt increases rapidly with the mass of the hadron and the event charged-particle multiplicity, independently of the center-of-mass energy. The fully corrected pt spectra and integrated yields are compared to various tunes of the PYTHIA6 and PYTHIA8 event generators.

Search for a light charged Higgs boson in top quark decays in pp collisions at √s = 7 TeV

Abstract: Results are presented on a search for a light charged Higgs boson that can be produced in the decay of the top quark to charged H and b quark and which, in turn, decays into tau and tau neutrino. The analysed data correspond to an integrated luminosity of about 2 inverse femtobarns recorded in proton-proton collisions at sqrt(s) = 7 TeV by the CMS experiment at the LHC. The search is sensitive to the decays of the top quark pairs t anti-t to charged Higgs W b anti-b and t anti-t to charged Higgs b anti-b. Various final states have been studied separately, all requiring presence of a tau lepton from charged Higgs decays, missing transverse energy, and multiple jets. Upper limits on the branching fraction B(t to charged Higgs b) in the range of 2-3% are established for charged Higgs boson masses between 80 and 160 GeV, under the assumption that B(charged Higgs to tau anti-tau neutrino) = 1.

Measurement of the single-top-quark t-channel cross section in pp collisions at √s=7 TeV

Abstract: A measurement of the single-top-quark t-channel production cross section in pp collisions at s√=7 TeV with the CMS detector at the LHC is presented. Two different and complementary approaches have been followed. The first approach exploits the distributions of the pseudorapidity of the recoil jet and reconstructed top-quark mass using background estimates determined from control samples in data. The second approach is based on multivariate analysis techniques that probe the compatibility of the candidate events with the signal. Data have been collected for the muon and electron final states, corresponding to integrated luminosities of 1.17 and 1.56 fb^(−1), respectively. The single-top-quark production cross section in the t-channel is measured to be 67.2±6.1 pb, in agreement with the approximate next-to-next-to-leading-order standard model prediction. Using the standard model electroweak couplings, the CKM matrix element |V_(tb)| is measured to be 1.020 ± 0.046 (meas.) ± 0.017 (theor.).

Search for neutral Higgs bosons decaying to tau pairs in pp collisions at √s = 7 TeV

Abstract: A search for neutral Higgs bosons decaying to tau pairs at a center-of-mass energy of 7 TeV is performed using a dataset corresponding to an integrated luminosity of 4.6 fb^(−1) recorded by the CMS experiment at the LHC. The search is sensitive to both the standard model Higgs boson and to the neutral Higgs bosons predicted by the minimal supersymmetric extension of the standard model (MSSM). No excess of events is observed in the tau-pair invariant-mass spectrum. For a standard model Higgs boson in the mass range of 110–145 GeV upper limits at 95% confidence level (CL) on the production cross section are determined. We exclude a Higgs boson with m_H=115 GeV with a production cross section 3.2 times of that predicted by the standard model. In the MSSM, upper limits on the neutral Higgs boson production cross section times branching fraction to tau pairs, as a function of the pseudoscalar Higgs boson mass, m_A, sets stringent new bounds in the parameter space, excluding at 95% CL values of tan β as low as 7.1 at m_A=160 GeV in the m^(max)_h benchmark scenario.

Decentralized optimal dispatch of distributed energy resources

Abstract: In this paper, we address the problem of optimally dispatching a set of distributed energy resources (DERs) without relying on a centralized decision maker. We consider a scenario where each DER can provide a certain resource (e.g., active or reactive power) at some cost (namely, quadratic in the amount of resource), with the additional constraint that the amount of resource that each DER provides is upper and lower bounded by its capacity limits. We propose a low-complexity iterative algorithm for DER optimal dispatch that relies, at each iteration, on simple computations using local information acquired through exchange of information with neighboring DERs. We show convergence of the proposed algorithm to the (unique) optimal solution of the DER dispatch problem. We also describe a wireless testbed we developed for testing the performance of the algorithms.

Centrality dependence of dihadron correlations and azimuthal anisotropy harmonics in PbPb collisions at √SNN = 2.76 Tev

Abstract: Measurements from the CMS experiment at the LHC of dihadron correlations for charged particles produced in PbPb collisions at a nucleon-nucleon centre-of-mass energy of 2.76 TeV are presented. The results are reported as a function of the particle transverse momenta (pt) and collision centrality over a broad range in relative pseudorapidity [Delta(eta)] and the full range of relative azimuthal angle [Delta(phi)]. The observed two-dimensional correlation structure in Delta(eta) and Delta(phi) is characterised by a narrow peak at Delta(eta), Delta(phi) approximately (0, 0) from jet-like correlations and a long-range structure that persists up to at least |Delta(eta)| = 4. An enhancement of the magnitude of the short-range jet peak is observed with increasing centrality, especially for particles of pt around 1-2 GeV/c. The long-range azimuthal dihadron correlations are extensively studied using a Fourier decomposition analysis. The extracted Fourier coefficients are found to factorise into a product of single-particle azimuthal anisotropies up to pt approximately 3-3.5 GeV/c for at least one particle from each pair, except for the second-order harmonics in the most central PbPb events. Various orders of the single-particle azimuthal anisotropy harmonics are extracted for associated particle pt of 1-3 GeV/c, as a function of the trigger particle pt up to 20 GeV/c and over the full centrality range.

Measurements of the angular distributions in the decays B→K(*)μ(+)μ(-) at CDF.

Abstract: We reconstruct the decays B → K(*) µ+µ- and measure their angular distributions in pp collisions at √s = 1.96 TeV using a data sample corresponding to an integrated luminosity of 6.8 fb-1. The transverse polarization asymmetry AT(2) and the time-reversal-odd charge-and-parity asymmetry Aim are measured for the first time, together with the K* longitudinal polarization fraction FL and the µ on forward-backward asymmetry AFB, for the decays B0→K*0µ+µ- and B0→K*+µ+µ-. Our results are among the most accurate to date and consistent with those from other experiments.

Measurement of the rapidity and transverse momentum distributions of Z bosons in pp collisions at √(s)=7TeV

Abstract: Measurements of the normalized rapidity (y) and transverse momentum (qT) distributions of Drell-Yan muon and electron pairs in the Z-boson mass region (60