Institution
University of Guadalajara
Education•Guadalajara, Mexico•
About: University of Guadalajara is a education organization based out in Guadalajara, Mexico. It is known for research contribution in the topics: Population & Context (language use). The organization has 13040 authors who have published 17399 publications receiving 168085 citations. The organization is also known as: UdeG & UdG.
Topics: Population, Context (language use), Control theory, Computer science, Artificial neural network
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors review the applications of deep learning (DL) methods in genomic selection (GS) to obtain a meta-picture of GS performance and highlight how these tools can help solve challenging plant breeding problems.
Abstract: Several conventional genomic Bayesian (or no Bayesian) prediction methods have been proposed including the standard additive genetic effect model for which the variance components are estimated with mixed model equations. In recent years, deep learning (DL) methods have been considered in the context of genomic prediction. The DL methods are nonparametric models providing flexibility to adapt to complicated associations between data and output with the ability to adapt to very complex patterns. We review the applications of deep learning (DL) methods in genomic selection (GS) to obtain a meta-picture of GS performance and highlight how these tools can help solve challenging plant breeding problems. We also provide general guidance for the effective use of DL methods including the fundamentals of DL and the requirements for its appropriate use. We discuss the pros and cons of this technique compared to traditional genomic prediction approaches as well as the current trends in DL applications. The main requirement for using DL is the quality and sufficiently large training data. Although, based on current literature GS in plant and animal breeding we did not find clear superiority of DL in terms of prediction power compared to conventional genome based prediction models. Nevertheless, there are clear evidences that DL algorithms capture nonlinear patterns more efficiently than conventional genome based. Deep learning algorithms are able to integrate data from different sources as is usually needed in GS assisted breeding and it shows the ability for improving prediction accuracy for large plant breeding data. It is important to apply DL to large training-testing data sets.
77 citations
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TL;DR: It was found that older and clinically severe patients were significantly associated with longer times of admission to the emergency room and an educational campaign to inform the population about the importance of receiving prompt attention following a scorpion sting has potential value in reducing complications in theEmergency room.
77 citations
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TL;DR: This work will show that THC paradoxically promotes hippocampal neurogenesis, prevents neurodegenerative processes occurring in animal models of Alzheimer's disease, protects from inflammation‐induced cognitive damage and restores memory and cognitive function in old mice within the framework of hormesis.
Abstract: A generally undesired effect of cannabis smoking is a reversible disruption of short-term memory induced by delta-9-tetrahydrocannabinol (THC), the primary psychoactive component of cannabis. However, this paradigm has been recently challenged by a group of scientists who have shown that THC is also able to improve neurological function in old animals when chronically administered at low concentrations. Moreover, recent studies demonstrated that THC paradoxically promotes hippocampal neurogenesis, prevents neurodegenerative processes occurring in animal models of Alzheimer's disease, protects from inflammation-induced cognitive damage and restores memory and cognitive function in old mice. With the aim to reconcile these seemingly contradictory facts, this work will show that such paradox can be explained within the framework of hormesis, defined as a biphasic dose-response.
77 citations
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TL;DR: In this article, the viability of producing energy and agricultural soil conditioners with biochars and bio-oils from the pyrolysis of biomasses that in some cases are potential environmental pollutants was explored.
77 citations
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TL;DR: The main cells involved in MS pathogenesis are described, both from neural tissue and from the immune system, and including a new participant, the adipocyte, focusing on their roles in MS.
Abstract: Multiple Sclerosis (MS) is an autoimmune disorder of the Central Nervous System that has been associated with several environmental factors, such as diet and obesity. The possible link between MS and obesity has become more interesting in recent years since the discovery of the remarkable properties of adipose tissue. Once MS is initiated, obesity can contribute to increased disease severity by negatively influencing disease progress and treatment response, but, also, obesity in early life is highly relevant as a susceptibility factor and causally related risk for late MS development. The aim of this review was to discuss recent evidence about the link between obesity, as a chronic inflammatory state, and the pathogenesis of MS as a chronic autoimmune and inflammatory disease. First, we describe the main cells involved in MS pathogenesis, both from neural tissue and from the immune system, and including a new participant, the adipocyte, focusing on their roles in MS. Second, we concentrate on the role of several adipokines that are able to participate in the mediation of the immune response in MS and on the possible cross talk between the latter. Finally, we explore recent therapy that involves the transplantation of adipocyte precursor cells for the treatment of MS.
77 citations
Authors
Showing all 13179 results
Name | H-index | Papers | Citations |
---|---|---|---|
Charles A. Dinarello | 190 | 1058 | 139668 |
Pierre Bourdieu | 153 | 592 | 194586 |
Markus M. Nöthen | 125 | 943 | 83156 |
Charles Antzelevitch | 118 | 515 | 54661 |
Alvaro Muñoz | 88 | 334 | 29117 |
Zygmunt Bauman | 73 | 313 | 34032 |
Judith Butler | 68 | 228 | 68959 |
Jean-Philippe Steyer | 66 | 351 | 17338 |
Saskia Sassen | 66 | 195 | 31185 |
Juan Carlos Diaz-Velez | 64 | 334 | 14252 |
Miguel Martínez-Ramos | 59 | 164 | 11748 |
Hendrik Vilstrup | 54 | 388 | 10884 |
Leonardo Trasande | 51 | 212 | 22305 |
Luis Cisneros-Zevallos | 50 | 149 | 10494 |
Elena R. Alvarez-Buylla | 49 | 172 | 8237 |