University of Guadalajara

About: University of Guadalajara is a education organization based out in Guadalajara, Mexico. It is known for research contribution in the topics: Population & Context (language use). The organization has 13040 authors who have published 17399 publications receiving 168085 citations. The organization is also known as: UdeG & UdG.

Power in Simplicity with ASM: Tracing the Aggressive Space Mapping Algorithm Over Two Decades of Development and Engineering Applications

Abstract: The most widely used space mapping approach to efficient design optimization is the aggressive space mapping (ASM) algorithm. My purpose here is to present both a historical account and a technical reassessment of ASM, starting with the invention of the space mapping concept and continuing with a brief overview of the most fundamental space mapping optimization methods developed until now, within which ASM is framed. The article goes on to review over two decades of ASM evolution, in terms not only of the theoretical contributions directly incorporated into the ASM algorithm but also of the most significant engineering applications documented for ASM to date.

Megabase-scale inversion polymorphism in the wild ancestor of maize

Abstract: Chromosomal inversions are thought to play a special role in local adaptation, through dramatic suppression of recombination, which favors the maintenance of locally adapted alleles. However, relatively few inversions have been characterized in population genomic data. On the basis of single-nucleotide polymorphism (SNP) genotyping across a large panel of Zea mays, we have identified an ∼50-Mb region on the short arm of chromosome 1 where patterns of polymorphism are highly consistent with a polymorphic paracentric inversion that captures >700 genes. Comparison to other taxa in Zea and Tripsacum suggests that the derived, inverted state is present only in the wild Z. mays subspecies parviglumis and mexicana and is completely absent in domesticated maize. Patterns of polymorphism suggest that the inversion is ancient and geographically widespread in parviglumis. Cytological screens find little evidence for inversion loops, suggesting that inversion heterozygotes may suffer few crossover-induced fitness consequences. The inversion polymorphism shows evidence of adaptive evolution, including a strong altitudinal cline, a statistical association with environmental variables and phenotypic traits, and a skewed haplotype frequency spectrum for inverted alleles.

Fine mapping of the Autosomal Dominant Split Hand/Split Foot Locus on Chromosome 7, Band q21.3-q22.1

Abstract: Split hand/split foot (SHFD) is a human developmental defect characterized by missing digits, fusion of remaining digits, and a deep median cleft in the hands and feet. Cytogenetic studies of deletions and translocations associated with this disorder have indicated that an autosomal dominant split hand/split foot locus (gene SHFD1) maps to 7q21-q22. To characterize the SHFD1 locus, somatic cell hybrid lines were constructed from cytogenetically abnormal individuals with SHFD. Molecular analysis resulted in the localization of 93 DNA markers to one of 10 intervals surrounding the SHFD1 locus. The translocation breakpoints in four SHFD patients were encompassed by the smallest region of overlap among the SHFD-associated deletions. The order of DNA markers in the SHFD1 critical region has been defined as PON-D7S812-SHFD1-D7S811-ASNS. One DNA marker, D7S811, detected altered restriction enzyme fragments in three patients with translocations when examined by pulsed-field gel electrophoresis (PFGE). These data map SHFD1, a gene that is crucial for human limb differentiation, to a small interval in the q21.3-q.22.1 region of human chromosome 7. 54 refs., 4 figs., 2 tabs.