University of Hyderabad

About: University of Hyderabad is a education organization based out in Hyderabad, India. It is known for research contribution in the topics: Catalysis & Crystal structure. The organization has 6446 authors who have published 13005 publications receiving 237641 citations. The organization is also known as: Hyderabad Central University & HCU.

LRS Bianchi type-I cosmological model in f ( R , T ) theory of gravity with Λ ( T )

Abstract: The locally rotationally symmetric (LRS) Bianchi type-I cosmological models have been investigated in f(R,T) theory of gravity, where R is the Ricci scalar and T is the trace of the energy momentum tensor, for some choices of the functional f(R,T)=f 1(R)+f 2(T). The exact solutions of the field equations are obtained for the linearly varying deceleration parameter q(t) proposed by Akarsu and Dereli (2012). Keeping an eye on the accelerating nature of the universe in the present epoch, the dynamics and physical behaviour of the models have been discussed. It is interesting to note that in one of the model, the universe ends with a big rip. By taking different functional forms for f 2(T) we have investigated whether or not the Big Rip can be avoided. We found that, the Big Rip situation can not be avoided and may be inherent in the linearly varying deceleration parameter. We have also applied the State-finder diagnostics to get the geometrical dynamics of the universe at different phases.

Curcumin: pharmaceutical solids as a platform to improve solubility and bioavailability

Abstract: Curcumin (CUR) is the prime curcuminoid in the Indian dietary spice turmeric, Curcuma longa, a plant of the Zingiberaceae family. CUR has promising and diverse therapeutic benefits, such as antioxidant, anti-inflammatory, antitumor, anti-hyperglycemic, antimalarial, antibacterial, and antiviral activity, including anti-Alzheimer's disease. However, CUR is yet to reach the status of a therapeutic drug candidate mainly because a standard solid dosage of curcumin suffers from poor oral bioavailability (0.05 μg mL−1, less than 1%). The reasons behind its low bioavailability include poor solubility (<8 μg mL−1 in water), low permeability and absorption, and rapid metabolism (short elimination half-life of <2 h). A successful CUR therapy requires an appropriate formulation system that will enhance the bioavailability and offer greater therapeutic efficacy. This review covers a comprehensive description of the CUR pharmaceutical solids, such as polymorphs, cocrystals, eutectics, and coamorphous solid-state forms with aim to determine ways to improve its physicochemical properties, including dissolution rate, solubility, physicochemical stability, mechanical strength, compressibility for tablet formation, and oral bioavailability. The cumulative publications in the past decade have forecast a bright future for development of an oral drug formulation of curcumin.

One-Dimensional Coordination Polymers of Silver(I) with Aminomethylpyridines. Example of a Triple Helical Infinite Chain

Abstract: Crystal structures of the three isomeric compounds Ag(2-amp)ClO4 (1), Ag(3-amp)ClO4 (2), and Ag(4-amp)ClO4 (3) reveal different packing arrangements of one-dimensional (1-D) infinite chain coordination polymers, formed in each case by the coordination of Ag to the pyridine N and amino N atoms from two different ligand molecules. 1: triclinic, space group P1, with a = 7.672(6) A, b = 11.1401(11) A, c = 11.322(4) A, α = 91.207(14)°, β = 105.52(4)°, γ = 90.48(2)°, and Z = 2. 2: monoclinic, space group P21/c, with a = 8.345(4) A, b = 8.6748(7) A, c = 26.056(9) A, β = 97.96(4)°, and Z = 4. 3: hexagonal, space group P6522, with a = 9.3154(11) A, c = 39.313(5) A, and Z = 12. 1 consists of zigzag chains, while 2 is made up of triple helical chains generating a tunnel space large enough to hold half the anions inside it. 3 has a highly symmetrical arrangement of 12 crystallographically equivalent chains held by weak Ag···Ag bonds. The crystal packing of the 1-D polymers in this case may be described in terms o...

Electrodynamics on $κ$-Minkowski space-time

Abstract: In this paper, we derive Lorentz force and Maxwell's equations on kappa-Minkowski space-time up to the first order in the deformation parameter. This is done by elevating the principle of minimal coupling to noncommutative space-time. We also show the equivalence of minimal coupling prescription and Feynman's approach. It is shown that the motion in kappa space-time can be interpreted as motion in a background gravitational field, which is induced by this noncommutativity. In the static limit, the effect of kappa deformation is to scale the electric charge. We also show that the laws of electrodynamics depend on the mass of the charged particle, in kappa space-time.

Mechanism of antibacterial action of the alcoholic extracts of Hemidesmus indicus (L.) R. Br. ex Schult, Leucas aspera (Wild.), Plumbago zeylanica L., and Tridax procumbens (L.) R. Br. ex Schult.

Abstract: Herbal products derived from Hemidesmus indicus (L) R Br ex Schult, Leucas aspera (Wild), Plumbago zeylanica L, and Tridax procumbens (L) R Br ex Schult are widely used in traditional medicine Though the extracts of these plants were found to be antimicrobial in nature and have the potential to be used in clinics, the mechanism of action of is not reported The ethanolic extracts of Hemidesmus indicus (L) R Br ex Schult, Hemidesmus indicus ethanolic extract (HIEE), Leucas aspera (Wild), Leucas aspera ethanolic extract (LAEE), Plumbago zeylanica L, Plumbago zeylanica ethanolic extract (PZEE), and Tridax procumbens (L) R Br ex Schult, Tridax procumbens ethanolic extract (TPEE) were tested for their antibacterial activity against E coli Antibacterial activity was analyzed by CFU assay and the effect on the bacterial membrane by fluorescence activated cell sorting and scanning electron microscopy LAEE, PZEE, and HIEE displayed potent bacterial killing activity in a time and concentration dependent manner TPEE did not display appreciable antibacterial activity The antibacterial action involved disruption of membrane potential, inner membrane permeabilization, blebbing and leakage of cellular contents Our results contribute to the understanding of the antibacterial mechanism of alcoholic extracts of the medicinal plants used in this study