University of Hyderabad

About: University of Hyderabad is a education organization based out in Hyderabad, India. It is known for research contribution in the topics: Catalysis & Crystal structure. The organization has 6446 authors who have published 13005 publications receiving 237641 citations. The organization is also known as: Hyderabad Central University & HCU.

Effect of alkaline earths on spectroscopic and structural properties of Cu2 + ions-doped lithium borate glasses

Abstract: Alkaline earth lithium borate glasses with composition 15RO–25Li2O–(60-x)B2O3: xCuO (where R = Ca, Ba and x = 0, 0.4 and 0.8) were prepared by the conventional melt quenching technique. X-ray diffractograms confirm the amorphous nature of the glass samples. Spectroscopic studies such as optical absorption, EPR and FTIR were used to understand the effect of modifier oxide and CuO dopant in the glass matrix. From the optical absorption spectra the absorption band which is attributed to the 2B1g → 2B2g characteristic transition of Cu2 + ions in the distorted octahedral sites. The cut-off wavelength (λc), optical band gap (Eopt), and Urbach energy (ΔE) were also determined. The average electronic polarizability of the oxide ion αo2 −(Eopt), optical basicity Λ(Eopt) and Yamashita–Kurosawa's interaction parameter A(Eopt) were also examined. From the EPR spectra the spin-Hamiltonian parameters are evaluated. The values of spin-Hamiltonian parameters indicate that the site symmetry around Cu2 + ions is tetragonally distorted octahedral. Using electron paramagnetic resonance (EPR) and optical absorption data, the molecular orbital coefficients α2 and β21 are calculated. The FTIR studies show that these glasses are made up of BO3 and BO4 units. The variation of optical and spectroscopic parameters was discussed in terms of the ionic radius of alkaline earth metal modifier.

Medicinal Chemistry of Quinolines As Emerging Anti-inflammatory Agents: An Overview

Abstract: Quinoline-based small molecules have been explored and being developed as anti-inflammatory agents targeting several pharmacological targets namely Phosphodiesterase 4 (PDE4), Transient Receptor Potential Vanilloid 1 (TRPV1), TNF-α converting enzyme (TACE) and Cyclooxygenase (COX). Efforts on Structure Activity Relationship (SAR) studies revealed that the pharmacological activities and target specificities of these quinoline derivatives were mainly dependent on the nature and position of substituent(s) present on the quinoline ring. For example, quinolines having carboxamide moiety displayed TRPV1 antagonism whereas that with carboxylic acid showed COX-inhibition. Similarly, quinolines possessing aniline moiety at C-4, aryl group at C-8 and oxazole ring at C-5 showed PDE4 inhibition. These quinoline derivatives were synthesized by using various synthetic approaches like Pd-mediated C-C (e.g. Suzuki, Sonogashira type coupling etc.) or C-N (the Buchwald-Hartwig type coupling) or C-S bond formation, AlCl₃ induced C-C bond formation, traditional amide bond formation or amination, formation of ether linkage or additional heterocyclic rings. All these efforts resulted in the discovery of several quinoline-based anti-inflammatory agents for the potential treatment of acute as well as chronic inflammatory diseases.