Institution
University of Hyderabad
Education•Hyderabad, India•
About: University of Hyderabad is a education organization based out in Hyderabad, India. It is known for research contribution in the topics: Catalysis & Crystal structure. The organization has 6446 authors who have published 13005 publications receiving 237641 citations. The organization is also known as: Hyderabad Central University & HCU.
Topics: Catalysis, Crystal structure, Thin film, Laser, Hydrogen bond
Papers published on a yearly basis
Papers
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TL;DR: How such processes influence heavy metal uptake through various biogeochemical processes including translocation, transformation, chelation, immobilization, solubilization, precipitation, volatilization and complexation of heavy metals ultimately facilitating phytoremediation is illustrated.
752 citations
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TL;DR: Acyclic activated alkenes/ alkynes and Asymmetric Baylis-Hillman Reaction: Earlier Developments 5495.
Abstract: 2. Essential Components: Earlier Developments 5449 2.1. Activated alkenes/alkynes 5450 2.1.1. Acyclic activated alkenes/ alkynes 5450 2.1.2. Cyclic activated alkenes 5451 2.2. Electrophiles 5451 2.3. Catalysts 5452 3. Essential Components: Recent Developments 5452 3.1. Activated Alkenes/Alkynes 5452 3.2. Electrophiles 5460 3.3. Catalysts 5477 4. Asymmetric Baylis-Hillman Reaction: Earlier Developments 5495
752 citations
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Agency for Science, Technology and Research1, Indian Institute of Chemical Technology2, Indian Institute of Technology Kharagpur3, Indian Institute of Science Education and Research, Mohali4, Indian Institute of Science5, University of South Florida6, Indian Institute of Technology Delhi7, University of Hyderabad8, Novartis9, Massachusetts Institute of Technology10, University of Michigan11, University of Alabama12, Georgetown University13, Council of Scientific and Industrial Research14, Merck & Co.15, Dr. Reddy's Laboratories16
TL;DR: A discussion of the FDA guidance on regulatory classification of pharmaceutical cocrystals of active pharmaceutical ingredients (APIs) was held in Manesar near Delhi, India, from February 2-4, 2012 as mentioned in this paper.
Abstract: The December 2011 release of a draft United States Food and Drug Administration (FDA) guidance concerning regulatory classification of pharmaceutical cocrystals of active pharmaceutical ingredients (APIs) addressed two matters of topical interest to the crystal engineering and pharmaceutical science communities: (1) a proposed definition of cocrystals; (2) a proposed classification of pharmaceutical cocrystals as dissociable “API-excipient” molecular complexes. The Indo–U.S. Bilateral Meeting sponsored by the Indo–U.S. Science and Technology Forum titled The Evolving Role of Solid State Chemistry in Pharmaceutical Science was held in Manesar near Delhi, India, from February 2–4, 2012. A session of the meeting was devoted to discussion of the FDA guidance draft. The debate generated strong consensus on the need to define cocrystals more broadly and to classify them like salts. It was also concluded that the diversity of API crystal forms makes it difficult to classify solid forms into three categories that...
734 citations
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TL;DR: This review focuses on specific suicidal proteases active towards PARP-1 to generate signature PARp-1 fragments that can identify key proteases and particular forms of cell death involved in pathophysiology.
Abstract: The normal function of poly (ADP-ribose) polymerase-1 (PARP-1) is the routine repair of DNA damage by adding poly (ADP ribose) polymers in response to a variety of cellular stresses. Recently, it has become widely appreciated that PARP-1 also participates in diverse physiological and pathological functions from cell survival to several forms of cell death and has been implicated in gene transcription, immune responses, inflammation, learning, memory, synaptic functions, angiogenesis and aging. In the CNS, PARP inhibition attenuates injury in pathologies like cerebral ischemia, trauma and excitotoxicity demonstrating a central role of PARP-1 in these pathologies. PARP-1 is also a preferred substrate for several 'suicidal' proteases and the proteolytic action of suicidal proteases (caspases, calpains, cathepsins, granzymes and matrix metalloproteinases (MMPs)) on PARP-1 produces several specific proteolytic cleavage fragments with different molecular weights. These PARP-1 signature fragments are recognized biomarkers for specific patterns of protease activity in unique cell death programs. This review focuses on specific suicidal proteases active towards PARP-1 to generate signature PARP-1 fragments that can identify key proteases and particular forms of cell death involved in pathophysiology. The roles played by some of the PARP-1 fragments and their associated binding partners in the control of different forms of cell death are also discussed.
688 citations
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TL;DR: The existence and nature of C−H···F−C interactions in crystalline fluorobenzenes 1−3 and 7−10 are discussed in this paper, where the authors compare the C−F−O/C−H−N interactions in these four crystal structures.
Abstract: The existence and nature of C−H···F−C interactions in crystalline fluorobenzenes 1−3 and 7−10 are discussed. These compounds were chosen because they contain only C, H, and F atoms; this is necessary in the evaluation of the weak acceptor capabilities of the C−F group. All of these compounds are liquids at room temperature, and single crystals for X-ray diffraction were grown in situ. The analysis of the C−H···F interactions that are found in all of these crystal structures takes the form of comparisons with related C−H···O/C−H···N analogues. Fluorobenzene, 1, bears a close relationship to pyridinium fluoride, pyridine 1-oxide, and benzonitrile at the level of individual interactions, showing that the character of the structure-determining intermolecular interactions in these four crystal structures are the same. Similarly, 1,4-difluorobenzene, 3, and 1,4-benzoquinone are related, the C−H···F interactions in the former playing the same structural role as the C−H···O interactions in the latter. A compariso...
637 citations
Authors
Showing all 6548 results
Name | H-index | Papers | Citations |
---|---|---|---|
Rajesh Kumar | 149 | 4439 | 140830 |
Bhawna Gomber | 125 | 1088 | 72998 |
Roald Hoffmann | 116 | 870 | 59470 |
Robert W. Boyd | 98 | 1161 | 37321 |
Gautam R. Desiraju | 88 | 458 | 45301 |
Shyam Sundar | 86 | 614 | 30289 |
Rukhsana Sultana | 76 | 162 | 14110 |
Rahul Banerjee | 73 | 203 | 21478 |
Judith A. K. Howard | 71 | 1318 | 44362 |
Girish S. Agarwal | 69 | 718 | 20780 |
Francis D'Souza | 66 | 477 | 16662 |
Praveen K. Thallapally | 64 | 190 | 12110 |
Kotha Subbaramaiah | 64 | 148 | 16020 |
Ashwini Nangia | 63 | 299 | 13057 |
E. C. G. Sudarshan | 59 | 379 | 21539 |