University of Mainz

About: University of Mainz is a education organization based out in Mainz, Rheinland-Pfalz, Germany. It is known for research contribution in the topics: Population & Immune system. The organization has 37673 authors who have published 71163 publications receiving 2497880 citations. The organization is also known as: Johannes Gutenberg-Universität Mainz & Universität Mainz.

Evolving therapies for liver fibrosis

Abstract: Fibrosis is an intrinsic response to chronic injury, maintaining organ integrity when extensive necrosis or apoptosis occurs. With protracted damage, fibrosis can progress toward excessive scarring and organ failure, as in liver cirrhosis. To date, antifibrotic treatment of fibrosis represents an unconquered area for drug development, with enormous potential but also high risks. Preclinical research has yielded numerous targets for antifibrotic agents, some of which have entered early-phase clinical studies, but progress has been hampered due to the relative lack of sensitive and specific biomarkers to measure fibrosis progression or reversal. Here we focus on antifibrotic approaches for liver that address specific cell types and functional units that orchestrate fibrotic wound healing responses and have a sound preclinical database or antifibrotic activity in early clinical trials. We also touch upon relevant clinical study endpoints, optimal study design, and developments in fibrosis imaging and biomarkers.

Accretionary growth and crust formation in the Central Asian Orogenic Belt and comparison with the Arabian-Nubian shield

Abstract: Kroner, A., Windley, B.F., Badarch, G., Tomurtogoo, O., Hegner, E., Jahn, B.M., Gruschka, S., Khain, E.V., Demoux, A., and Wingate, M.T.D., 2007, Accretionary growth and crust formation in the Central Asian Orogenic Belt and comparison with the Arabian-Nubian shield, in Hatcher, R.D., Jr., Carlson, M.P., McBride, J.H., and Martinez Catalan, J.R., eds., 4-D Framework of Continental Crust: Geological Society of America Memoir 200, p. 181–209, doi: 10.1130/2007.1200(11). For permission to copy, contact editing@geosociety.org. ©2007 The Geological Society of America. All rights reserved. *Kroner: kroener@mail.uni-mainz.de; Windley: brian.windley@btinternet.com; Tomurtogoo: igmr@magicnet.mn; Hegner: hegner@lmu.de; Jahn: jahn@earth. sinica.edu.tw; Khain: khain@ginras.ru; Demoux: demoux@uni-mainz.de; Wingate: mwingate@tsrc.uwa.edu.au.

Polymerization of Ethylene Oxide, Propylene Oxide, and Other Alkylene Oxides: Synthesis, Novel Polymer Architectures, and Bioconjugation.

Abstract: The review summarizes current trends and developments in the polymerization of alkylene oxides in the last two decades since 1995, with a particular focus on the most important epoxide monomers ethylene oxide (EO), propylene oxide (PO), and butylene oxide (BO). Classical synthetic pathways, i.e., anionic polymerization, coordination polymerization, and cationic polymerization of epoxides (oxiranes), are briefly reviewed. The main focus of the review lies on more recent and in some cases metal-free methods for epoxide polymerization, i.e., the activated monomer strategy, the use of organocatalysts, such as N-heterocyclic carbenes (NHCs) and N-heterocyclic olefins (NHOs) as well as phosphazene bases. In addition, the commercially relevant double-metal cyanide (DMC) catalyst systems are discussed. Besides the synthetic progress, new types of multifunctional linear PEG (mf-PEG) and PPO structures accessible by copolymerization of EO or PO with functional epoxide comonomers are presented as well as complex bra...

Climate change at the 4.2 ka BP termination of the Indus valley civilization and Holocene south Asian monsoon variability

Abstract: [1] Planktonic oxygen isotope ratios off the Indus delta reveal climate changes with a multi-centennial pacing during the last 6 ka, with the most prominent change recorded at 4.2 ka BP. Opposing isotopic trends across the northern Arabian Sea surface at that time indicate a reduction in Indus river discharge and suggest that later cycles also reflect variations in total annual rainfall over south Asia. The 4.2 ka event is coherent with the termination of urban Harappan civilization in the Indus valley. Thus, drought may have initiated southeastward habitat tracking within the Harappan cultural domain. The late Holocene drought cycles following the 4.2 ka BP event vary between 200 and 800 years and are coherent with the evolution of cosmogenic 14C production rates. This suggests that solar variability is one fundamental cause behind Holocene rainfall changes over south Asia.