Institution
University of Mainz
Education•Mainz, Rheinland-Pfalz, Germany•
About: University of Mainz is a education organization based out in Mainz, Rheinland-Pfalz, Germany. It is known for research contribution in the topics: Population & Immune system. The organization has 37673 authors who have published 71163 publications receiving 2497880 citations. The organization is also known as: Johannes Gutenberg-Universität Mainz & Universität Mainz.
Topics: Population, Immune system, Antigen, Cancer, Large Hadron Collider
Papers published on a yearly basis
Papers
More filters
••
TL;DR: This work presents 13 lineages derived from the dorsal part of the neuroectoderm of Drosophila and assigns 12 of them to identified NBs, providing a foundation for the interpretation of mutant phenotypes and for future investigations on cell fate specification and differentiation.
538 citations
••
Max Planck Society1, Free University of Berlin2, University of Colorado Boulder3, University of Oxford4, Royal Berkshire NHS Foundation Trust5, University of Ioannina6, Harvard University7, Mayo Clinic8, University of Miami9, University of Tübingen10, German Center for Neurodegenerative Diseases11, Boston University12, Emory University13, University of British Columbia14, Indiana University15, Wadsworth Center16, University College London17, VU University Amsterdam18, University of Lübeck19, University of Chicago20, University of Toulouse21, Centre national de la recherche scientifique22, National Institutes of Health23, Kobe University24, deCODE genetics25, University of Washington26, University of Münster27, Centers for Disease Control and Prevention28, University of Mainz29
TL;DR: This study provides an exhaustive and up-to-date summary of the status of PD genetics research that can be readily scaled to include the results of future large-scale genetics projects, including next-generation sequencing studies.
Abstract: More than 800 published genetic association studies have implicated dozens of potential risk loci in Parkinson’s disease (PD). To facilitate the interpretation of these findings, we have created a dedicated online resource, PDGene, that comprehensively collects and meta-analyzes all published studies in the field. A systematic literature screen of ,27,000 articles yielded 828 eligible articles from which relevant data were extracted. In addition, individual-level data from three publicly available genome-wide association studies (GWAS) were obtained and subjected to genotype imputation and analysis. Overall, we performed meta-analyses on more than seven million polymorphisms originating either from GWAS datasets and/or from smaller scale PD association studies. Metaanalyses on 147 SNPs were supplemented by unpublished GWAS data from up to 16,452 PD cases and 48,810 controls. Eleven loci showed genome-wide significant (P,5610 28 ) association with disease risk: BST1, CCDC62/HIP1R, DGKQ/GAK, GBA, LRRK2, MAPT, MCCC1/LAMP3 ,P ARK16,SNCA, STK39 ,a ndSYT11/RAB25. In addition, we identified novel evidence for genome-wide significant association with a polymorphism in ITGA8 (rs7077361, OR 0.88, P=1.3610 28 ). All meta-analysis results are freely available on a dedicated online database (www.pdgene.org), which is cross-linked with a customized track on the UCSC Genome Browser. Our study provides an exhaustive and up-to-date summary of the status of PD genetics research that can be readily scaled to include the results of future large-scale genetics projects, including next-generation sequencing studies.
537 citations
••
TL;DR: In this article, the basic photophysical phenomena together with representative examples such as nitroprusside derivatives, relevant spin crossover complexes, stilbenoid complexes and finally Prussian blue analogues are discussed.
535 citations
••
TL;DR: Current understanding of neutrophils in host-pathogen interactions and disease involvement is summarized, illustrating the versatility and plasticity of the neutrophil, moving between host defence, immune modulation, and tissue damage.
Abstract: Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of infection, where they fulfill their life-saving antimicrobial functions. While traditionally regarded as short-lived phagocytes, recent findings on long-term survival, neutrophil extracellular trap (NET) formation, heterogeneity and plasticity, suppressive functions, and tissue injury have expanded our understanding of their diverse role in infection and inflammation. This review summarises our current understanding of neutrophils in host-pathogen interactions and disease involvement, illustrating the versatility and plasticity of the neutrophil, moving between host defence, immune modulation, and tissue damage.
533 citations
••
TL;DR: The data suggest that NKCC1 may play a pivotal role in the generation of GABA‐mediated depolarization in immature CP cells, while KCC2 promotes the later maturation of GABAergic inhibition in the rat neocortex.
Abstract: GABA is the principal inhibitory neurotransmitter in the mature brain, but during early postnatal development the elevated [Cl−]i in immature neocortical neurones causes GABAA receptor activation to be depolarizing. The molecular mechanisms underlying this intracellular Cl− accumulation remain controversial. Therefore, the GABA reversal potential (EGABA) or [Cl−]i in early postnatal rat neocortical neurones was measured by the gramicidin-perforated patch-clamp method, and the relative expression levels of the cation−Cl− cotransporter mRNAs (in the same cells) were examined by semiquantitative single-cell multiplex RT-PCR to look for statistical correlations with [Cl−]i. The mRNA expression levels were positively (the Cl− accumulating Na+,K+−2Cl− cotransporter NKCC1) or negatively (the Cl− extruding K+−Cl− cotransporter KCC2) correlated with [Cl−]i. NKCC1 mRNA expression was high in early postnatal days, but decreased during postnatal development, whereas KCC2 mRNA expression displayed the opposite pattern. [Cl−]i and NKCC1 mRNA expression were each higher in cortical plate (CP) neurones than in the presumably older layer V/VI pyramidal neurones in a given slice. The pharmacological effects of bumetanide on EGABA were consistent with the different expression levels of NKCC1 mRNA. These data suggest that NKCC1 may play a pivotal role in the generation of GABA-mediated depolarization in immature CP cells, while KCC2 promotes the later maturation of GABAergic inhibition in the rat neocortex.
533 citations
Authors
Showing all 38009 results
Name | H-index | Papers | Citations |
---|---|---|---|
Patrick W. Serruys | 186 | 2427 | 173210 |
Michael Kramer | 167 | 1713 | 127224 |
Marc Weber | 167 | 2716 | 153502 |
Klaus Müllen | 164 | 2125 | 140748 |
J. E. Brau | 162 | 1949 | 157675 |
Wolfgang Wagner | 156 | 2342 | 123391 |
Thomas Meitinger | 155 | 716 | 108491 |
Florian Holsboer | 151 | 929 | 86351 |
Jongmin Lee | 150 | 2257 | 134772 |
György Buzsáki | 150 | 446 | 96433 |
Galen D. Stucky | 144 | 958 | 101796 |
Yi Yang | 143 | 2456 | 92268 |
Brajesh C Choudhary | 143 | 1618 | 108058 |
Tim Adye | 143 | 1898 | 109010 |
Karl Jakobs | 138 | 1379 | 97670 |