University of Pavia

About: University of Pavia is a education organization based out in Pavia, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 21173 authors who have published 52524 publications receiving 1610492 citations. The organization is also known as: Università degli Studi di Pavia & Università di Pavia.

Update 1 of: C2-symmetric chiral bis(oxazoline) ligands in asymmetric catalysis.

Abstract: Update 1 of: C2-Symmetric Chiral Bis(oxazoline) Ligands in Asymmetric Catalysis Giovanni Desimoni,* Giuseppe Faita, and Karl Anker Jørgensen* Department of Organic Chemistry, University of Pavia, Viale Taramelli 10, 27100 Pavia, Italy Danish National Research Foundation: Center for Catalysis, Department of Chemistry, Aarhus University, DK-8000 Aarhus C, Denmark This is a Chemical Reviews Perennial Review. The root paper of this title was published in Chem. Rev. 2006, 106 (9), 3561 3651, DOI: 10.1021/cr0505324; Published (Web) August 2, 2006. Updates to the text appear in red type

Updated standard operating procedures for electrochemotherapy of cutaneous tumours and skin metastases

Abstract: Electrochemotherapy is now in routine clinical use to treat cutaneous metastases of any histology, and is listed in national and international guidelines for cutaneous metastases and primary skin cancer. Electrochemotherapy is used by dermatologists, surgeons, and oncologists, and for different degrees and manifestations of metastases to skin and primary skin tumours not amenable to surgery. This treatment utilises electric pulses to permeabilize cell membranes in tumours, thus allowing a dramatic increase of the cytotoxicity of anti-cancer agents. Response rates, often after only one treatment, are very high across all tumour types. The most frequent indications are cutaneous metastases from malignant melanoma and breast cancer. In 2006, standard operating procedures (SOPs) were written for this novel technology, greatly facilitating introduction and dissemination of the therapy. Since then considerable experience has been obtained treating a wider range of tumour histologies and increasing size of tumours which was not originally thought possible. A pan-European expert panel drawn from a range of disciplines from dermatology, general surgery, head and neck surgery, plastic surgery, and oncology met to form a consensus opinion to update the SOPs based on the experience obtained. This paper contains these updated recommendations for indications for electrochemotherapy, pre-treatment information and evaluation, treatment choices, as well as follow-up.

Trace-Element Partitioning Between Amphibole and Silicate Melt

Abstract: Knowledge of the partitioning behavior of trace elements between solid and liquid is a prerequisite for modern igneous and mantle petrology. Most of the mathematical models simulating melt generation, migration and evolution within the mantle and/or the crust require the availability of reliable solid/liquid partition coefficients for the mineral phases involved in the process. Calcic amphiboles are extremely important for the understanding of lithospheric processes because of both their common occurrence in a variety of igneous and metamorphic rocks types and their capability of hosting a large number of geochemically important trace elements. A series of studies on the partitioning behavior of trace elements between calcic amphibole and silicate melt have therefore been carried out at different pressures, temperatures and system compositions during the last 15 years. However, due to the complex crystal chemistry of amphiboles, only few studies focused on the role of crystal structure and composition on amphibole-liquid partition coefficients (Amph/LD). In this chapter, present knowledge of the solid/ liquid trace element partitioning between calcic amphiboles and silicate melt is summarized and the role played by the crystal structure and melt composition on Amph/LD variations is highlighted in addition to the effects of pressure and temperature. The dataset used in this chapter includes only the results of experimental studies performed under well constrained P - T conditions for which trace element determinations were carried out with highly sensitive in situ microanalytical techniques. The available dataset considered in this work are listed in Table 1⇓. Although far less common than the calcic amphiboles, potassic-richterites are potentially important in the generation of potassic magmatic rocks and in re-enrichment processes occurring in the subcontinental mantle lithosphere sampled as xenoliths in kimberlites. A comprehensive experimental study of trace element partitioning between synthetic potassic richterites and silicate melts has …

Juvenile Hemochromatosis Locus Maps to Chromosome 1q

Abstract: Summary Juvenile hemochromatosis (JH) is an autosomal recessive disorder that leads to severe iron loading in the 2d to 3d decade of life. Affected members in families with JH do not show linkage to chromosome 6p and do not have mutations in the HFE gene that lead to the common hereditary hemochromatosis. In this study we performed a genomewide search to map the JH locus in nine families: six consanguineous and three with multiple affected patients. This strategy allowed us to identify the JH locus on the long arm of chromosome 1. A maximum LOD score of 5.75 at a recombination fraction of 0 was detected with marker D1S498, and a LOD score of 5.16 at a recombination fraction of 0 was detected for marker D1S2344. Homozygosity mapping in consanguineous families defined the limits of the candidate region in an ∼4-cM interval between markers D1S442 and D1S2347. Analysis of genes mapped in this interval excluded obvious candidates. The JH locus does not correspond to the chromosomal localization of any known gene involved in iron metabolism. These findings provide a means to recognize, at an early age, patients in affected families. They also provide a starting point for the identification of the affected gene by positional cloning.