University of Southampton

About: University of Southampton is a education organization based out in Southampton, United Kingdom. It is known for research contribution in the topics: Population & Laser. The organization has 37184 authors who have published 99400 publications receiving 3462915 citations. The organization is also known as: Southampton University & Soton Uni.

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

Abstract: To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P = 8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.

Standardization of food challenges in patients with immediate reactions to foods--position paper from the European Academy of Allergology and Clinical Immunology.

Abstract: At present, the double blind placebo controlled foodchallenge(DBPCFC)representstheonlywaytoestablishorruleoutanadversereactiontoafoodinolderchildrenand adults, whereas an open challenge controlled bytrained personnel is sufficient in infants and youngchildren (1). The challenge procedure is not, however,C.Bindslev-Jensen

Full duplex techniques for 5G networks: self-interference cancellation, protocol design, and relay selection

Abstract: The wireless research community aspires to conceive full duplex operation by supporting concurrent transmission and reception in a single time/frequency channel for the sake of improving the attainable spectral efficiency by a factor of two as compared to the family of conventional half duplex wireless systems. The main challenge encountered in implementing FD wireless devices is that of finding techniques for mitigating the performance degradation imposed by self-interference. In this article, we investigate the potential FD techniques, including passive suppression, active analog cancellation, and active digital cancellation, and highlight their pros and cons. Furthermore, the troubles of FD medium access control protocol design are discussed for addressing the problems such as the resultant end-to-end delay and network congestion. Additionally, an opportunistic decode-andforward- based relay selection scheme is analyzed in underlay cognitive networks communicating over independent and identically distributed Rayleigh and Nakagami-m fading channels in the context of FD relaying. We demonstrate that the outage probability of multi-relay cooperative communication links can be substantially reduced. Finally, we discuss the challenges imposed by the aforementioned techniques and a range of critical issues associated with practical FD implementations. It is shown that numerous open challenges, such as efficient SI suppression, high-performance FD MAC-layer protocol design, low power consumption, and hybrid FD/HD designs, have to be tackled before successfully implementing FD-based systems.