University of Southampton

About: University of Southampton is a education organization based out in Southampton, United Kingdom. It is known for research contribution in the topics: Population & Laser. The organization has 37184 authors who have published 99400 publications receiving 3462915 citations. The organization is also known as: Southampton University & Soton Uni.

The Data Deluge: An e-Science Perspective

Abstract: This paper previews the imminent flood of scientific data expected from the next generation of experiments, simulations, sensors and satellites. In order to be exploited by search engines and data mining software tools, such experimental data needs to be annotated with relevant metadata giving information as to provenance, content, conditions and so on. The case for automating the process of going from raw data to information to knowledge is briefly discussed. The paper argues the case for creating new types of digital libraries for scientific data with the same sort of management services as conventional digital libraries in addition to other data-specific services. Some likely implications of both the Open Archives Initiative and e-Science data for the future role for university libraries are briefly mentioned. A substantial subset of this e-Science data needs to archived and curated for long-term preservation. Some of the issues involved in the digital preservation of both scientific data and of the programs needed to interpret the data are reviewed. Finally, the implications of this wealth of e-Science data for the Grid middleware infrastructure are highlighted. * Postal address: EPSRC, Polaris House, North Star Avenue, Swindon SN2 1 ET, UK + On secondment from the Department of Electronics and Computer Science, University of Southampton, Southampton SO17 1BJ, UK

Revised Starling equation and the glycocalyx model of transvascular fluid exchange: an improved paradigm for prescribing intravenous fluid therapy

Abstract: Summary I.V. fluid therapy does not result in the extracellular volume distribution expected from Starling's original model of semi-permeable capillaries subject to hydrostatic and oncotic pressure gradients within the extracellular fluid. Fluid therapy to support the circulation relies on applying a physiological paradigm that better explains clinical and research observations. The revised Starling equation based on recent research considers the contributions of the endothelial glycocalyx layer (EGL), the endothelial basement membrane, and the extracellular matrix. The characteristics of capillaries in various tissues are reviewed and some clinical corollaries considered. The oncotic pressure difference across the EGL opposes, but does not reverse, the filtration rate (the ‘no absorption' rule) and is an important feature of the revised paradigm and highlights the limitations of attempting to prevent or treat oedema by transfusing colloids. Filtered fluid returns to the circulation as lymph. The EGL excludes larger molecules and occupies a substantial volume of the intravascular space and therefore requires a new interpretation of dilution studies of blood volume and the speculation that protection or restoration of the EGL might be an important therapeutic goal. An explanation for the phenomenon of context sensitivity of fluid volume kinetics is offered, and the proposal that crystalloid resuscitation from low capillary pressures is rational. Any potential advantage of plasma or plasma substitutes over crystalloids for volume expansion only manifests itself at higher capillary pressures.

26 Tbit s-1 line-rate super-channel transmission utilizing all-optical fast Fourier transform processing

Abstract: Optical transmission systems with terabit per second (Tbit s-1) single-channel line rates no longer seem to be too far-fetched. New services such as cloud computing, three-dimensional high-definition television and virtual-reality applications require unprecedented optical channel bandwidths. These high-capacity optical channels, however, are fed from lower-bitrate signals. The question then is whether the lower-bitrate tributary information can viably, energy-efficiently and effortlessly be encoded to and extracted from terabit per second data streams. We demonstrate an optical fast Fourier transform scheme that provides the necessary computing power to encode lower-bitrate tributaries into 10.8 and 26.0 Tbit s-1 line-rate orthogonal frequency division multiplexing (OFDM) data streams and to decode them from fibre-transmitted OFDM data streams. Experiments show the feasibility and ease of handling terabit per second data with low energy consumption. To the best of our knowledge, this is the largest line rate ever encoded onto a single light source.

Effects of adaptive cruise control and highly automated driving on workload and situation awareness: A review of the empirical evidence

Abstract: Adaptive cruise control (ACC), a driver assistance system that controls longitudinal motion, has been introduced in consumer cars in 1995. A next milestone is highly automated driving (HAD), a system that automates both longitudinal and lateral motion. We investigated the effects of ACC and HAD on drivers' workload and situation awareness through a meta-analysis and narrative review of simulator and on-road studies. Based on a total of 32 studies, the unweighted mean self-reported workload was 43.5% for manual driving, 38.6% for ACC driving, and 22.7% for HAD (0% = minimum, 100 = maximum on the NASA Task Load Index or Rating Scale Mental Effort). Based on 12 studies, the number of tasks completed on an in-vehicle display relative to manual driving (100%) was 112% for ACC and 261% for HAD. Drivers of a highly automated car, and to a lesser extent ACC drivers, are likely to pick up tasks that are unrelated to driving. Both ACC and HAD can result in improved situation awareness compared to manual driving if drivers are motivated or instructed to detect objects in the environment. However, if drivers are engaged in non-driving tasks, situation awareness deteriorates for ACC and HAD compared to manual driving. The results of this review are consistent with the hypothesis that, from a Human Factors perspective, HAD is markedly different from ACC driving, because the driver of a highly automated car has the possibility, for better or worse, to divert attention to secondary tasks, whereas an ACC driver still has to attend to the roadway.