Institution
University of Southampton
Education•Southampton, United Kingdom•
About: University of Southampton is a education organization based out in Southampton, United Kingdom. It is known for research contribution in the topics: Population & Laser. The organization has 37184 authors who have published 99400 publications receiving 3462915 citations. The organization is also known as: Southampton University & Soton Uni.
Topics: Population, Laser, Context (language use), Optical fiber, Fiber laser
Papers published on a yearly basis
Papers
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St Mary's Hospital1, University of Southampton2, University Hospital Southampton NHS Foundation Trust3, Heidelberg University4, Swiss Institute of Allergy and Asthma Research5, National Institutes of Health6, Erasmus University Rotterdam7, Odense University Hospital8, Nippon Medical School9, University of Cyprus10, University of Edinburgh11, Charité12, University of Messina13, Eskişehir Osmangazi University14, Boston Children's Hospital15, Katholieke Universiteit Leuven16, Utrecht University17, Johns Hopkins University18, Athens State University19, University Medical Center Groningen20, University of Milan21, University College Hospital22, King's College London23, Medical University of Graz24, European Union25, Capital Medical University26, Transylvania University27, Northern General Hospital28, Hospital Clínico San Carlos29, Wrocław Medical University30, University of Amsterdam31, University of Padua32
TL;DR: In general, broad evidence for the clinical efficacy of AIT for AR exists but a product‐specific evaluation of evidence is recommended, and SCIT and SLIT are recommended for both seasonal and perennial AR for its short‐term benefit.
Abstract: Allergic rhinoconjunctivitis (AR) is an allergic disorder of the nose and eyes affecting about a fifth of the general population. Symptoms of AR can be controlled with allergen avoidance measures and pharmacotherapy. However, many patients continue to have ongoing symptoms and an impaired quality of life; pharmacotherapy may also induce some side-effects. Allergen immunotherapy (AIT) represents the only currently available treatment that targets the underlying pathophysiology, and it may have a disease-modifying effect. Either the subcutaneous (SCIT) or sublingual (SLIT) routes may be used. This Guideline has been prepared by the European Academy of Allergy and Clinical Immunology's (EAACI) Taskforce on AIT for AR and is part of the EAACI presidential project "EAACI Guidelines on Allergen Immunotherapy." It aims to provide evidence-based clinical recommendations and has been informed by a formal systematic review and meta-analysis. Its generation has followed the Appraisal of Guidelines for Research and Evaluation (AGREE II) approach. The process included involvement of the full range of stakeholders. In general, broad evidence for the clinical efficacy of AIT for AR exists but a product-specific evaluation of evidence is recommended. In general, SCIT and SLIT are recommended for both seasonal and perennial AR for its short-term benefit. The strongest evidence for long-term benefit is documented for grass AIT (especially for the grass tablets) where long-term benefit is seen. To achieve long-term efficacy, it is recommended that a minimum of 3 years of therapy is used. Many gaps in the evidence base exist, particularly around long-term benefit and use in children.
436 citations
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TL;DR: In this article, the authors review the theory of quantum systems with ultrastrong coupling, which includes entangled ground states with virtual excitations, new avenues for nonlinear optics, and connections to several important physical models.
Abstract: Ultrastrong coupling between light and matter has, in the past decade, transitioned from theoretical idea to experimental reality. It is a new regime of quantum light-matter interaction, going beyond weak and strong coupling to make the coupling strength comparable to the transition frequencies in the system. The achievement of weak and strong coupling has led to increased control of quantum systems and applications like lasers, quantum sensing, and quantum information processing. Here we review the theory of quantum systems with ultrastrong coupling, which includes entangled ground states with virtual excitations, new avenues for nonlinear optics, and connections to several important physical models. We also review the multitude of experimental setups, including superconducting circuits, organic molecules, semiconductor polaritons, and optomechanics, that now have achieved ultrastrong coupling. We then discuss the many potential applications that these achievements enable in physics and chemistry.
436 citations
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University of Cambridge1, Mansfield University of Pennsylvania2, Imperial College London3, Fritz Haber Institute of the Max Planck Society4, University of Graz5, University of Bonn6, University of Southampton7, Radboud University Nijmegen8, Princeton University9, Panjab University, Chandigarh10, Tulane University11, University of Toronto12, Carnegie Mellon University13, Cornell University14, Utrecht University15, OpenEye Scientific Software16, University of Utah17, Facultad de Ciencias Exactas y Naturales18, Toyohashi University of Technology19, University College London20, Polaris Industries21, University of Silesia in Katowice22, Argonne National Laboratory23, Rutgers University24, Max Planck Society25, University of Luxembourg26, New York University27, New York University Shanghai28, Courant Institute of Mathematical Sciences29, Loyola University Chicago30
TL;DR: The results of the sixth blind test of organic crystal structure prediction methods are presented and discussed, highlighting progress for salts, hydrates and bulky flexible molecules, as well as on-going challenges.
Abstract: The sixth blind test of organic crystal structure prediction (CSP) methods has been held, with five target systems: a small nearly rigid molecule, a polymorphic former drug candidate, a chloride salt hydrate, a co-crystal and a bulky flexible molecule. This blind test has seen substantial growth in the number of participants, with the broad range of prediction methods giving a unique insight into the state of the art in the field. Significant progress has been seen in treating flexible molecules, usage of hierarchical approaches to ranking structures, the application of density-functional approximations, and the establishment of new workflows and `best practices' for performing CSP calculations. All of the targets, apart from a single potentially disordered Z' = 2 polymorph of the drug candidate, were predicted by at least one submission. Despite many remaining challenges, it is clear that CSP methods are becoming more applicable to a wider range of real systems, including salts, hydrates and larger flexible molecules. The results also highlight the potential for CSP calculations to complement and augment experimental studies of organic solid forms.
435 citations
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TL;DR: Using satellite imagery and census data for greater than 1000 agglomerations in the East-Southeast Asian region, the authors show that urban land increased to greater than 22 percent between 2000 and 2010 (from 155 000 to 189 000 square kilometers), an amount equivalent to the area of Taiwan, while urban populations climbed greater than 31 percent (from 738 to 969 million).
Abstract: East–Southeast Asia is currently one of the fastest urbanizing regions in the world, with countries such as China climbing from 20 to 50 percent urbanized in just a few decades. By 2050, these countries are projected to add 1 billion people, with 90 percent of that growth occurring in cities. This population shift parallels an equally astounding amount of built-up land expansion. However, spatially-and temporally detailed information on regional-scale changes in urban land or population distribution do not exist; previous efforts have been either sample-based, focused on one country, or drawn conclusions from datasets with substantial temporal/spatial mismatch and variability in urban definitions. Using consistent methodology, satellite imagery and census data for greater than1000 agglomerations in the East–Southeast Asian region, the authors show that urban land increased to greater than 22 percent between 2000 and 2010 (from 155 000 to 189 000 square kilometers), an amount equivalent to the area of Taiwan, while urban populations climbed greater than 31 percent (from 738 to 969 million). Although urban land expanded at unprecedented rates, urban populations grew more rapidly, resulting in increasing densities for the majority of urban agglomerations, including those in both more developed (Japan, South Korea) and industrializing nations (China, Vietnam, Indonesia). This result contrasts previous sample-based studies, which conclude that cities are universally declining in density. The patterns and rates of change uncovered by these datasets provide a unique record of the massive urban transition currently underway in East–Southeast Asia that is impacting local-regional climate, pollution levels, water quality and availability, arable land, as well as the livelihoods and vulnerability of populations in the region.
435 citations
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TL;DR: The high risk of falling among people with stroke was evident in this community-based sample and repeat fallers had greater mobility deficits and significantly reduced arm function and ADL ability than those who did not report any instability.
434 citations
Authors
Showing all 37632 results
Name | H-index | Papers | Citations |
---|---|---|---|
Cyrus Cooper | 204 | 1869 | 206782 |
Stephen V. Faraone | 188 | 1427 | 140298 |
David R. Williams | 178 | 2034 | 138789 |
Charles M. Lieber | 165 | 521 | 132811 |
David W. Johnson | 160 | 2714 | 140778 |
Mark E. Cooper | 158 | 1463 | 124887 |
Pete Smith | 156 | 2464 | 138819 |
Joseph Jankovic | 153 | 1146 | 93840 |
Vivek Sharma | 150 | 3030 | 136228 |
David J.P. Barker | 148 | 446 | 99373 |
Debbie A Lawlor | 147 | 1114 | 101123 |
Olli T. Raitakari | 142 | 1232 | 103487 |
Stephen T. Holgate | 142 | 870 | 82345 |
Alexander Belyaev | 142 | 1895 | 100796 |
Christopher D.M. Fletcher | 138 | 674 | 82484 |