University of Southampton

About: University of Southampton is a education organization based out in Southampton, United Kingdom. It is known for research contribution in the topics: Population & Laser. The organization has 37184 authors who have published 99400 publications receiving 3462915 citations. The organization is also known as: Southampton University & Soton Uni.

Human Factors Methods: A Practical Guide for Engineering and Design

Abstract: This second edition of Human Factors Methods: A Practical Guide for Engineering and Design now presents 107 design and evaluation methods as well as numerous refinements to those that featured in the original. The book has been carefully designed to act as an ergonomics methods manual, aiding both students and practitioners. The eleven sections represent the different categories of ergonomics methods and techniques that can be used in the evaluation and design process. Offering a 'how-to' text on a substantial range of ergonomics methods that can be used in the design and evaluation of products and systems, it is a comprehensive point of reference for all these methods. An overview of the methods is presented in chapter one, with a methods matrix showing which can be used in conjunction. The following chapters detail the methods showing how to apply them in practice. Flowcharts, procedures and examples cover the requirements of a diverse audience and varied applications of the methods. The final chapter, a new addition, illustrates the EAST method, which integrates several well-known methods into a teamwork analysis approach.

The Role of Ligands in the Chemical Synthesis and Applications of Inorganic Nanoparticles.

Abstract: The design of nanoparticles is critical for their efficient use in many applications ranging from biomedicine to sensing and energy. While shape and size are responsible for the properties of the inorganic nanoparticle core, the choice of ligands is of utmost importance for the colloidal stability and function of the nanoparticles. Moreover, the selection of ligands employed in nanoparticle synthesis can determine their final size and shape. Ligands added after nanoparticle synthesis infer both new properties as well as provide enhanced colloidal stability. In this article, we provide a comprehensive review on the role of the ligands with respect to the nanoparticle morphology, stability, and function. We analyze the interaction of nanoparticle surface and ligands with different chemical groups, the types of bonding, the final dispersibility of ligand-coated nanoparticles in complex media, their reactivity, and their performance in biomedicine, photodetectors, photovoltaic devices, light-emitting devices, sensors, memory devices, thermoelectric applications, and catalysis.

A new class of multivariate skew distributions with applications to Bayesian regression models

Abstract: The authors develop a new class of distributions by introducing skewness in multivariate ellip- tically symmetric distributions. The class, which is obtained by using transformation and conditioning, contains many standard families including the multivariate skew-normal and distributions. The authors obtain analytical forms of the densities and study distributional properties. They give practical applica- tions in Bayesian regression models and results on the existence of the posterior distributions and moments under improper priors for the regression coefficients. They illustrate their methods using practical examples.

Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma

Abstract: Follicular lymphoma is an incurable malignancy, with transformation to an aggressive subtype representing a critical event during disease progression. Here we performed whole-genome or whole-exome sequencing on 10 follicular lymphoma-transformed follicular lymphoma pairs followed by deep sequencing of 28 genes in an extension cohort, and we report the key events and evolutionary processes governing tumor initiation and transformation. Tumor evolution occurred through either a 'rich' or 'sparse' ancestral common progenitor clone (CPC). We identified recurrent mutations in linker histone, JAK-STAT signaling, NF-κB signaling and B cell developmental genes. Longitudinal analyses identified early driver mutations in chromatin regulator genes (CREBBP, EZH2 and KMT2D (MLL2)), whereas mutations in EBF1 and regulators of NF-κB signaling (MYD88 and TNFAIP3) were gained at transformation. Collectively, this study provides new insights into the genetic basis of follicular lymphoma and the clonal dynamics of transformation and suggests that personalizing therapies to target key genetic alterations in the CPC represents an attractive therapeutic strategy.