Institution
University of Texas at Dallas
Education•Richardson, Texas, United States•
About: University of Texas at Dallas is a education organization based out in Richardson, Texas, United States. It is known for research contribution in the topics: Population & Computer science. The organization has 14986 authors who have published 35589 publications receiving 1293714 citations. The organization is also known as: UT-Dallas & UT Dallas.
Papers published on a yearly basis
Papers
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TL;DR: Packaging of the prohormone in secretory vesicles, and acidification of this compartment, are critical steps in the proper proteolytic maturation of insulin.
335 citations
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TL;DR: Guided by feedback patterns observed on eBay and other platforms, laboratory experiments are run to investigate how reciprocity can be managed by changes in the way feedback information flows through the system, leading to more accurate reputation information, more trust, and more efficient trade.
Abstract: Reciprocity in feedback giving distorts the production and content of reputation information in a market, hampering trust and trade efficiency. Guided by feedback patterns observed on eBay and other platforms, we run laboratory experiments to investigate how reciprocity can be managed by changes in the way feedback information flows through the system, leading to more accurate reputation information, more trust, and more efficient trade. We discuss the implications for theory building and for managing the redesign of market trust systems.
This paper was accepted by Teck Ho, decision analysis.
335 citations
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TL;DR: This article presents MFA, reviews recent extensions, and illustrates it with a detailed example that shows the common factor scores could be obtained by replacing the original normalized data tables by the normalized factor scores obtained from the PCA of each of these tables.
Abstract: Multiple factor analysis MFA, also called multiple factorial analysis is an extension of principal component analysis PCA tailored to handle multiple data tables that measure sets of variables coll...
333 citations
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TL;DR: Esketamine is expected to address an unmet medical need in this population through its novel mechanism of action and rapid onset of antidepressant efficacy and is supported by the efficacy and safety of esketamine nasal spray as a rapidly acting antidepressant for patients with treatment-resistant depression.
Abstract: Objective:About one-third of patients with depression fail to achieve remission despite treatment with multiple antidepressants. This study compared the efficacy and safety of switching patients wi...
333 citations
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TL;DR: It would seem that although widely dissimilar, the UT and dialysis membrane chamber growth conditions promote more static patterns of gene expression in Borrelia burgdorferi, suggesting that once Bb gains entry and adapts to mammalian tissues, fewer differentially regulated genes are exploited.
Abstract: DNA microarrays were used to survey the adaptive genetic responses of Borrelia burgdorferi (Bb) B31, the Lyme disease spirochete, when grown under conditions analogous to those found in unfed ticks (UTs), fed ticks (FTs), or during mammalian host adaptation (Bb in dialysis membrane chambers implanted in rats). Microarrays contained 95.4% of the predicted B31 genes, 150 (8.6%) of which were differentially regulated (changes of ≥1.8-fold) among the three growth conditions. A substantial proportion (46%) of the differentially regulated genes encoded proteins with predicted export signals (29% from predicted lipoproteins), emphasizing the importance to Bb of modulating its extracellular proteome. For B31 cultivated at the more restrictive UT condition, microarray data provided evidence of a bacterial stringent response and factors that restrict cell division. A large proportion of genes were responsive to the FT growth condition, wherein increased temperature and reduced pH were prominent environmental parameters. A surprising theme, supported by cluster analysis, was that many of the gene expression changes induced during the FT growth condition were transient and largely tempered as B31 adapted to the mammalian host, suggesting that once Bb gains entry and adapts to mammalian tissues, fewer differentially regulated genes are exploited. It therefore would seem that although widely dissimilar, the UT and dialysis membrane chamber growth conditions promote more static patterns of gene expression in Bb. The microarray data thus provide a basis for formulating new testable hypotheses regarding the life cycle of Bb and attaining a more complete understanding of many aspects of Bb's complex parasitic strategies.
333 citations
Authors
Showing all 15148 results
Name | H-index | Papers | Citations |
---|---|---|---|
Eugene Braunwald | 230 | 1711 | 264576 |
Younan Xia | 216 | 943 | 175757 |
Eric N. Olson | 206 | 814 | 144586 |
Thomas C. Südhof | 191 | 653 | 118007 |
Scott M. Grundy | 187 | 841 | 231821 |
Jing Wang | 184 | 4046 | 202769 |
Eric Boerwinkle | 183 | 1321 | 170971 |
Eric J. Nestler | 178 | 748 | 116947 |
John D. Minna | 169 | 951 | 106363 |
Elliott M. Antman | 161 | 716 | 179462 |
Adi F. Gazdar | 157 | 776 | 104116 |
Bruce D. Walker | 155 | 779 | 86020 |
R. Kowalewski | 143 | 1815 | 135517 |
Joseph Izen | 137 | 1433 | 98900 |
James A. Richardson | 136 | 363 | 75778 |