Institution
University of Texas at Dallas
Education•Richardson, Texas, United States•
About: University of Texas at Dallas is a education organization based out in Richardson, Texas, United States. It is known for research contribution in the topics: Population & Computer science. The organization has 14986 authors who have published 35589 publications receiving 1293714 citations. The organization is also known as: UT-Dallas & UT Dallas.
Papers published on a yearly basis
Papers
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TL;DR: This paper proposes a new mobility model, called the hyper-Erlang distribution model, which is consistent with the requirements of field data processing in PCS network design and performance evaluation and derives analytical results for the channel holding time distribution, which are readily applicable to theHyper Erlang distribution models.
Abstract: Channel holding time is of primary importance in teletraffic analysis of PCS networks. This quantity depends on user's mobility which can be characterized by the cell residence time. We show that when the cell residence time is not exponentially distributed, the channel holding time is not exponentially distributed either, a fact also confirmed by available field data. In order to capture the essence of PCS network behaviour, including the characterization of channel holding time, a correct mobility model is therefore necessary. The new model must be good enough to fit field data, while at the same time resulting in a tractable queueing system. We propose a new mobility model, called the hyper-Erlang distribution model, which is consistent with these requirements. Under the new realistic operational assumption of this model, in which the cell residence time is generally distributed, we derive analytical results for the channel holding time distribution, which are readily applicable to the hyper-Erlang distribution models. Using the derived analytical results we demonstrate how the distribution of the cell residence time affects the channel holding time distribution. The results presented in this paper can provide guidelines for field data processing in PCS network design and performance evaluation.
274 citations
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11 Jul 2010TL;DR: The research focus of computational coreference resolution has exhibited a shift from heuristic approaches to machine learning approaches in the past decade.
Abstract: The research focus of computational coreference resolution has exhibited a shift from heuristic approaches to machine learning approaches in the past decade. This paper surveys the major milestones in supervised coreference research since its inception fifteen years ago.
274 citations
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TL;DR: In this paper, an improved measurement of the mass of the Higgs boson is derived from a combined fit to the reconstructed invariant mass spectra of the decay channels H -> gamma gamma and H -> ZZ* -> 4l.
Abstract: An improved measurement of the mass of the Higgs boson is derived from a combined fit to the reconstructed invariant mass spectra of the decay channels H -> gamma gamma and H -> ZZ* -> 4l. The analysis uses the pp collision data sample recorded by the ATLAS experiment at the CERN Large Hadron Collider at center-of-mass energies of 7 TeV and 8 TeV, corresponding to an integrated luminosity of 25 fb(-1). The measured value of the Higgs boson mass is m(H) = 125.36 +/- 0.37(stat) +/- 0.18 (syst) GeV. This result is based on improved energy-scale calibrations for photons, electrons, and muons as well as other analysis improvements, and supersedes the previous result from ATLAS. Upper limits on the total width of the Higgs boson are derived from fits to the invariant mass spectra of the H -> gamma gamma and H -> ZZ* -> 4l decay channels.
274 citations
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Baylor College of Medicine1, Tufts University2, University of Pittsburgh3, University of Texas at Dallas4, University of Texas at Austin5, Johns Hopkins University6, George Washington University7, University of Cincinnati8, Université de Montréal9, University of Wisconsin-Madison10, Ohio State University11
TL;DR: The need for age-relevant outcome measures for traumatic brain injury (TBI) research is addressed and the recommendations by the inter-agency Pediatric TBI Outcomes Workgroup are summarized.
Abstract: This article addresses the need for age-relevant outcome measures for traumatic brain injury (TBI) research and summarizes the recommendations by the inter-agency Pediatric TBI Outcomes Workgroup. The Pediatric Workgroup's recommendations address primary clinical research objectives including characterizing course of recovery from TBI, prediction of later outcome, measurement of treatment effects, and comparison of outcomes across studies. Consistent with other Common Data Elements (CDE) Workgroups, the Pediatric TBI Outcomes Workgroup adopted the standard three-tier system in its selection of measures. In the first tier, core measures included valid, robust, and widely applicable outcome measures with proven utility in pediatric TBI from each identified domain including academics, adaptive and daily living skills, family and environment, global outcome, health-related quality of life, infant and toddler measures, language and communication, neuropsychological impairment, physical functioning, ps...
274 citations
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TL;DR: Molecular modeling and quantitative structure-activity relationship studies demonstrated that most active analogs overlapped extensively with curacin A but failed to provide an explanation for the apparent structural analogy between curacIn A and colchicine.
Abstract: Originally purified as a major lipid component of a strain of the cyanobacterium Lyngbya majuscula isolated in Curacao, curacin A is a potent inhibitor of cell growth and mitosis, binding rapidly and tightly at the colchicine site of tubulin. Because its molecular structure differs so greatly from that of colchicine and other colchicine site inhibitors, we prepared a series of curacin A analogs to determine the important structural features of the molecule. These modifications include reduction and E-to-Z transitions of the olefinic bonds in the 14-carbon side chain of the molecule; disruption of and configurational changes in the cyclopropyl moiety; disruption, oxidation, and configurational reversal in the thiazoline moiety; configurational reversal and substituent modifications at C13; and demethylation at C10. Inhibitory effects on tubulin assembly, the binding of colchicine to tubulin, and the growth of MCF-7 human breast carcinoma cells were examined. The most important portions of curacin A required for its interaction with tubulin seem to be the thiazoline ring and the side chain at least through C4, the portion of the side chain including the C9-C10 olefinic bond, and the C10 methyl group. Only two modifications totally eliminated the tubulin-drug interaction. The inactive compounds were a segment containing most of the side chain, including its two substituents, and analogs in which the methyl group at the C13 oxygen atom was replaced by a benzoate residue. Antiproliferative activity comparable with that observed with curacin A was only reproduced in compounds that were potent inhibitors of the binding of colchicine to tubulin. Molecular modeling and quantitative structure-activity relationship studies demonstrated that most active analogs overlapped extensively with curacin A but failed to provide an explanation for the apparent structural analogy between curacin A and colchicine.
273 citations
Authors
Showing all 15148 results
Name | H-index | Papers | Citations |
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Eugene Braunwald | 230 | 1711 | 264576 |
Younan Xia | 216 | 943 | 175757 |
Eric N. Olson | 206 | 814 | 144586 |
Thomas C. Südhof | 191 | 653 | 118007 |
Scott M. Grundy | 187 | 841 | 231821 |
Jing Wang | 184 | 4046 | 202769 |
Eric Boerwinkle | 183 | 1321 | 170971 |
Eric J. Nestler | 178 | 748 | 116947 |
John D. Minna | 169 | 951 | 106363 |
Elliott M. Antman | 161 | 716 | 179462 |
Adi F. Gazdar | 157 | 776 | 104116 |
Bruce D. Walker | 155 | 779 | 86020 |
R. Kowalewski | 143 | 1815 | 135517 |
Joseph Izen | 137 | 1433 | 98900 |
James A. Richardson | 136 | 363 | 75778 |