University of Texas at Dallas

About: University of Texas at Dallas is a education organization based out in Richardson, Texas, United States. It is known for research contribution in the topics: Population & Computer science. The organization has 14986 authors who have published 35589 publications receiving 1293714 citations. The organization is also known as: UT-Dallas & UT Dallas.

The Impact of Representative Bureaucracies: Educational Systems and Public Policies

Abstract: Studies of representative bureaucracies are staples of public administration research; however, because of a variety of methodological problems, too few have been able to address the basic "so what?" question. Do bureaucracies with different levels of representativeness produce different policy outputs and have different policy impacts? Our research addresses these inquiries using data from the 67 public school districts in Florida. The analysis shows that when we focus on (a) bureaucrats who exercise discretion, (b) a demographic factor with a lasting impact-race, and (c) policy measures that are clearly salient to the chosen demographic factor, we can detect the relationships between bureaucratic representation and public policy outputs and outcomes. We particularly highlight the representativeness of "street-level" bureaucrats (in this case, teachers). Thus, the issue of representation in public bureaucracies possesses more than just symbolic importance.

A Role for miR-145 in Pulmonary Arterial Hypertension Evidence From Mouse Models and Patient Samples

Abstract: Rationale: Despite improved understanding of the underlying genetics, pulmonary arterial hypertension (PAH) remains a severe disease. Extensive remodeling of small pulmonary arteries, including proliferation of pulmonary artery smooth muscle cells (PASMCs), characterizes PAH. MicroRNAs (miRNAs) are noncoding RNAs that have been shown to play a role in vascular remodeling. Objective: We assessed the role of miR-145 in PAH. Methods and Results: We localized miR-145 in mouse lung to smooth muscle. Using quantitative PCR, we demonstrated increased expression of miR-145 in wild-type mice exposed to hypoxia. PAH was evaluated in miR-145 knockout and mice treated with anti-miRs via measurement of systolic right ventricular pressure, right ventricular hypertrophy, and percentage of remodeled pulmonary arteries. miR-145 deficiency and anti-miR–mediated reduction resulted in significant protection from the development of PAH. In contrast, miR-143 anti-miR had no effect. Furthermore, we observed upregulation of miR-145 in lung tissue of patients with idiopathic and heritable PAH compared with unaffected control subjects and demonstrated expression of miR-145 in SMC of remodeled vessels from such patients. Finally, we show elevated levels of miR-145 expression in primary PASMCs cultured from patients with BMPR2 mutations and also in the lungs of BMPR2 -deficient mice. Conclusions: miR-145 is dysregulated in mouse models of PAH. Downregulation of miR-145 protects against the development of PAH. In patient samples of heritable PAH and idiopathic PAH, miR-145 is expressed in remodeled vessels and mutations in BMPR2 lead to upregulation of miR-145 in mice and PAH patients. Manipulation of miR-145 may represent a novel strategy in PAH treatment.

Internal Capital Markets And Corporate Refocusing

Abstract: This paper develops a theory of organization based on the benefits and costs of internal capital markets. A central assumption is that the transaction cost of raising external funds is greater than the cost of internal funds. The benefit of internal resource allocation is that it gives the firm a real option to avoid external capital markets (and the associated deadweight transaction costs) in more states of the world than single-business firms. The cost is the internal resource flexibility exacerbates an over investment agency problem. The optimal focus is determined by trading off the benefit of the option against the cost of over investment. In this context, we show how the relative efficiency of integration and separation depends ultimately on assignment of control rights over cash flow. Testable implications are derived for the level of divisional investment, the sensitivity of divisional investment to cash flow, and the diversification discount.

Performance Politics and the British Voter

Abstract: What matters most to voters when they choose their leaders? This book suggests that performance politics is at the heart of contemporary democracy, with voters forming judgments about how well competing parties and leaders perform on important issues. Given the high stakes and uncertainty involved, voters rely heavily on partisan cues and party leader images as guides to electoral choice. However, the authors argue that the issue agenda of British politics has changed markedly in recent years. A cluster of concerns about crime, immigration and terrorism now mix with perennial economic and public service issues. Since voters and parties often share the same positions on these issues, political competition focuses on who can do the best job. This book shows that a model emphasizing flexible partisan attachments, party leader images and judgments of party competence on key issues can explain electoral choice in contemporary Britain.

Economic Freedom, Government Policy and the Trade-Off Between Equity and Economic Growth

Abstract: This study investigates the role that economicfreedom plays in economic growth and in the distribution in marketincome, the role of government policy in advancingeconomic progress and in promoting income equality, and the effectthat the rate of economic progress has on thedistribution of market income. Structural and reduced formmodels are estimated that reveal that economic freedompromotes both economic growth and equity, and that there is apositive but relatively small trade-off between growth andincome inequality.