Showing papers in "Bone and Mineral in 1989"

TL;DR: In this review the current information on the role of these proteins in the mineralized and mineralizing connective tissues is presented along with a synopsis of the methods currently being used to elucidate these functions.

TL;DR: It is suggested that even relatively high concentrations of Cl2MBP in the fluid phase do not affect osteoclasts, nor does contact with Cl2 MBP-coated bone surfaces, but that injury to osteoclast, and a consequent reduction in bone resorption, occurs when osteoclast excavate bone surfaces upon which Cl2mbP is adsorbed.

TL;DR: Addition of a low dose of APD to conventional treatment of osteoporosis does not only prevent bone loss but induces a continuous gain in bone mass, which justifies long-term prospective studies with uninterrupted low dose APD treatment in osteopsorosis.

TL;DR: Cross-sectional measurements of a number of variables related to bone in these 40 patients were compared to the values in various groups of healthy men aged 20-96, finding men with primary osteoporosis had reduced femoral cortical area/total area and Singh grade.

TL;DR: The results indicate that trabecular thinning and erosion are interdependent processes in age-related bone loss and imply that the site of activation of new BMUs may not be randomly distributed but may instead be preferentially located at sites of lower trABecular width.

TL;DR: Bone mineral density (BMD) of the spine and proximal femur in Japanese men and women was investigated with dual photon absorptiometry, using gadolinium-153 as discussed by the authors.

TL;DR: It is demonstrated that trabecular thinning contributes to age-related bone loss in both sexes, but to a greater extent in females than in males.

TL;DR: It is concluded that the assessment of risk factor status is not an efficient tool for the identification of perimenopausal women with low bone mass and dietary calcium intake is more important in the development and/or maintenance of peak bone mass, than in the modulation of postmenopausal bone loss.

TL;DR: It is concluded that an assessment of the risk of developing PMO with vertebral fractures cannot be based on the putative risk factors as measured in this study, but must bebased on measurement of bone mass.

TL;DR: The osteoporosis that occurs in the declining years of life has been the subject of various classification schemes, and the current Type IiType II classification 151 is considered to involve mainly trabecular bone, and to exhibit early onset, heavy female predominance and fractures principally of the distal forearm and spine.

TL;DR: It is concluded that this cyclical protocol resulted in short-term improvement in trabecular bone mass, but there is no evidence at a cellular level that long-term improvements in bone remodelling occurred.

TL;DR: Treatment with nandrolone decanoate does increase the bone mineral content; however, this may not be due to a direct increase in bone formation, and may be a combination of decreased bone resorption and increased muscle mass, which both play a beneficial role in conserving bone.

TL;DR: Crystal-collagen relationships in calcified turkey leg tendons and cortical bone and dentin of the rat were studied by bright field and selected-area dark field electron microscopy and apatite crystals were localized within both the gap and overlap zones of collagen fibrils even at very early stages of mineralization.

TL;DR: It is demonstrated that the osteoclast is derived from the pluripotent hemopoietic stem cell, and a combination of various growth factors is important for stem cell proliferation in vitro.

TL;DR: It seems also that estrogens exert both a straight inhibition of bone resorption and a partial inhibition of parathyroid responsiveness, which suggests that the bone sparing effects of estrogens may be due only to low circulating estradiol concentrations, but not to supraphysiological estrone levels.

TL;DR: The results indicate that antigonadal hormone drugs reduce bone mass to a varying extent and the often discussed intrinsic estrogen activity of the antiestrogens was present only in the highest dosage tested of tamoxifen.

TL;DR: The data indicate that swimming exercise exerts a positive effect on bone growth and development in young rats and emphasizes longitudinal and transversal growth.

TL;DR: The data suggest that osteoblasts are equipped with receptors for bradykinin coupled to prostaglandin production, and the degree of confluency of the cell cultures greatly influenced the amount of prostaglandsins being produced.

TL;DR: Photometrically, strain differences, especially the osteopenic state of SAM-P/6, occur, at least in part, by disparities in endosteal formation rates during cortical bone modelling.

TL;DR: The difference observed between resorption of those areas of bone surface and the failure of osteoclasts to resorb non-tissue substrates are discussed in relation to current theories of the mechanisms of mineral dissolution and resorbing in mammalian calcified tissues.

TL;DR: The small reduction in serum osteocalcin concentration in fracture patients is consistent with the hypothesis that reduced osteoblast function may contribute to the osteoporosis which results in hip fracture.

TL;DR: This paper showed that buffered aqueous 1,10-phenanthroline (OP), a metal ion chelator, eliminated the lag period, promoting immediate, enhanced Ca 2+ uptake.

TL;DR: Cartilage resorption during long bone development in the chick embryo varies in several crucial aspects from that in mammals, including the formation of an osteoid band along the walls of the marrow tunnels which prevents resorbing cells from gaining access to the cartilage matrix.

TL;DR: Algorithms and an algebra for estimating effects of bone turnover, remodelling space, undermineralized bone and trabecular surface-to-volume ratio effects on trABecular bone mass estimation by photon absorptiometry are offered.

TL;DR: Differences between the two groups in height, weight, thiazide use, exercise, exercise (in men), estrogen therapy (in women), and calcium and vitamin D intake accounted for much of the difference in BMC between the US-born and Japan-born women, but less so for the men.

TL;DR: Data from whole cell patch clamp studies on osteoblast-like rat osteosarcoma cells show the existence of L-type calcium channels in the cell membrane, strong evidence that ROS 17/2.8 cells have a significant number of 'L-type' calcium channels.

TL;DR: Comparison of these results to published data suggests that environmental factors may have influences on bone mass that are similar in magnitude to the effects of race.

TL;DR: Murine calvarial osteoblasts in monolayer culture were found to constitutively produce bone-resorbing factors; mechanical deformation significantly increased the synthesis and/or release of these factors.

TL;DR: It is concluded that serum levels of 25(OH)D3 and renal function are the main determinants for S-1,25( OH)2D3 in primary hyperparathyroidism.

TL;DR: The results suggest that the PGE2-induced stimulation of osteoclastic activity represents an indirect effect mediated by stromal cells derived from bone marrow.