Showing papers in "Chemico-Biological Interactions in 2022"

TL;DR: In this paper , a review of the chemical and biological aspects of metal ions and their possible interactions in living systems under normal and pathological conditions is presented, with a focus on the interaction between bioinorganic chemists and biophysicists.

TL;DR: In this paper , the authors reviewed the current knowledge and outline the gaps related to the relationship between CVD and COVID-19 with a focus on the renin-angiotensin-aldosterone system (RAAS).

TL;DR: In this article, the authors reviewed the current knowledge and outline the gaps related to the relationship between CVD and COVID-19 with a focus on the renin-angiotensin-aldosterone system (RAAS).

TL;DR: In this article , a comprehensive review of the pharmacology, phytochemistry and analytical methods of β-sitosterol is desired, and extensive research on β-stosterol as an anticancer nutraceutical is recommended.

TL;DR: In this paper , the effect of TGF-β signaling in fibrotic-associate lung, heart, liver, and kidney tissues, followed by a detailed discussion of canonical and non-canonical TGFβ signaling pathway.

TL;DR: Zhang et al. as mentioned in this paper investigated the potential role of Baicalein in cerebral I/R injury using oxygen-glucose deprivation and reoxygenation (OGD/R) HT22 cells, transient middle cerebral artery occlusion (tMCAO) mice and RSL3-sitmulated HT 22 cells.

TL;DR: In this paper , the role of mitochondria in Cd-induced toxicity in the kidney and proposes mitochondrial transference as a novel therapy based on transplanting healthy mitochondria to cells with Cdcompromised mitochondria.

TL;DR: In this article , the efficacy of Quercetin against the immunotoxic hazard of Ochratoxin A in broiler chickens was evaluated and it was shown that QuercETin (QUE) ameliorated most of the immunosuppressive effects of OTA by its immunomodulatory, antioxidant and anti-apoptotic activities.

TL;DR: In this paper, the efficacy of Quercetin against the immunotoxic hazard of Ochratoxin A in broiler chickens was evaluated and it was shown that QuercETin (QUE) ameliorated most of the immunosuppressive effects of OTA by its immunomodulatory, antioxidant and anti-apoptotic activities.

TL;DR: In this paper, a detailed assessment of hormetic dose responses by bone marrow stem cells (BMSCs) from a broad range of animal models and humans with particular emphasis on cell renewal (proliferation), cell differentiation and enhancing resilience to inflammatory stress was provided.

TL;DR: A preliminary review aimed to comprehensively discuss the features and uses of aptamer-conjugated carbon-based nanomaterials to manage cancer and bacterial infections is presented in this paper , where aptamer-functionalized nanoparticles have been used as nanoveicles for targeted delivery of anti-cancer agents (i.e., doxorubicin and 5fluorouracil) to tumor sites.

TL;DR: In this article , the role and connectivity of EGF with various cancers via signaling pathways, cell surface receptors mechanism, macromolecules, mitochondrial genes and neoplasm was highlighted.

TL;DR: In this paper , a detailed assessment of hormetic dose responses by bone marrow stem cells (BMSCs) from a broad range of animal models and humans with particular emphasis on cell renewal (proliferation), cell differentiation and enhancing resilience to inflammatory stress was provided.

TL;DR: In this paper , a review of commonly used in vitro immune-modulating techniques explaining their principles is presented and compared among 40 different assays and more than 150 sets of primers, the methods of cell proliferation by MTT, phagocytosis by neutral red, NO detection by Griess reaction and estimation of expression of TLRs, COX-2, iNOS, TNF-α, IL-6 and IL-1β by PCR have been the most widely used to screen the therapeutics under investigation.

TL;DR: In this paper, the role and connectivity of EGF with various cancers via signaling pathways, cell surface receptors mechanism, macromolecules, mitochondrial genes and neoplasm was highlighted.

TL;DR: In this paper , the synergism of monoterpene geraniol with clinically and non-clinically used compounds was explored as potential candidates for treating different types of cancer.

TL;DR: An overview of EGFR's structural anatomy and physiology, its role in cancers, and clinical studies that target EGFR in various tumours are included in this review as mentioned in this paper . But, despite significant progress, longterm remission from solid tumours is still a distant goal for many oncologists.

TL;DR: In this paper , the authors discuss the medical value of nutraceuticals briefly and their ability to mitigate various inflammatory lung diseases through targeting inhibition of NF-κB, which is one of the core and common factors of these diseases.

TL;DR: In this article , the authors investigated the role of TRPV1/Ca2+ in EVO-induced cytotoxicity in human gastric cancer cells and found that EVO exposure causes significant ROS generation and apoptotic cell death.

TL;DR: In this article , the authors investigated whether hesperidin (HSP) had a protective effect on paclitaxel-induced hepatotoxicity and nephrotoxicity from biochemical, and molecular perspectives.

TL;DR: In this paper, the authors investigated the role of TRPV1/Ca2+ in EVO-induced cytotoxicity in human gastric cancer cells and found that EVO exposure causes significant ROS generation and apoptotic cell death.

TL;DR: In this article , the effects of silver nanoparticles on the midgut tissues of beetles (Blaps polychresta) collected from Egypt as a biological model were investigated.

TL;DR: Zhang et al. as discussed by the authors explored the effect of Honokiol (HKL, C18H18O2) extract from the bark of Magnolia officinalis with anti-AD effect.

TL;DR: In this paper , the ability of venlafaxine to inhibit striatal histone deacetylase 6 (HDAC6) and to enhance α-synuclein clearance through activation of the ubiquitin proteasome system (UPS) and autophagy has been examined.

TL;DR: Zhang et al. as discussed by the authors explored the effect of Honokiol (HKL, C18H18O2) extract from the bark of Magnolia officinalis with anti-AD effect.

TL;DR: In this paper , the authors found that PFOA-induced hepatocellular endoplasmic reticulum (ER)-mitochondria communication via mitochondria-associated ER membranes (MAMs) can trigger mitochondrial-mediated apoptosis, thereby increasing the level of calcium ion and decreasing the levels of ΔΨm, simultaneously elevating the protein expressions of Cyclophilin D (CYPD), Bcl-2 homologous antagonist/killer (Bak), BCL-2-associated X protein (Bax), bcl-like protein 11 (Bim), cytochrome C (Cyt-C), 78 kDa glucose-regulated protein (GRP78), CCAAT/enhancer-binding protein (C/EBP), and thioredoxin-interacting protein (TXNIP), while inhibiting the protein expression of tumor necrosis factor receptor-associated protein 1 (TRAP1).

TL;DR: In this article , the authors review the informative data that supports the idea underlying the disruption mechanisms of the microbiome of the gastrointestinal tract in the acute COVID-19 or post-COVID-mediated elevation of severity biomarkers.

TL;DR: In this article , the authors discuss the recent research focused on the scientific value of ANNs in evaluation and prediction of toxicity of chemical compounds, and discuss how ANNs can be used to predict toxicity of various chemical compounds or classify the compounds based on their toxic effects.

TL;DR: In this article , the anti-CRC benefits of many plants conducted in vitro, as well as the phytochemical components of plants that may play a role in the study were discussed.

TL;DR: Chalcone derivatives have shown promising biological activities against cancer hallmarks such as proliferation, angiogenesis, invasion, metastasis, inflammation, stemness, and regulation of cancer epigenetics as mentioned in this paper .